Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain

Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability

(2013) Steven C.L. Ho et al.   JOURNAL OF BIOTECHNOLOGY

Functional heterogeneity and heritability in CHO cell populations

(2012) Sarah L. Davies et al.   BIOTECHNOLOGY AND BIOENGINEERING

Proteomic Analysis of Chinese Hamster Ovary Cells

(2012) Deniz Baycin-Hizal et al.   JOURNAL OF PROTEOME RESEARCH

Computer-aided antibody design

(2012) D. Kuroda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineering genes for predictable protein expression

(2012) Claes Gustafsson et al.   PROTEIN EXPRESSION AND PURIFICATION

An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer

(2011) Jane McLeod et al.   BIOTECHNOLOGY AND BIOENGINEERING

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

(2011) Sarah L. Davies et al.   BIOTECHNOLOGY PROGRESS

Engineering the variable region of therapeutic IgG antibodies

(2011) Tomoyuki Igawa et al.   mAbs

Analysis and Prediction of Translation Rate Based on Sequence and Functional Features of the mRNA

(2011) Tao Huang et al.   PLoS One

Probing the stability-limiting regions of an antibody single-chain variable fragment: a molecular dynamics simulation study

(2011) Ting Wang et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Multivariate data analysis on historical IPV production data for better process understanding and future improvements

(2010) Yvonne E. Thomassen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell line-specific control of recombinant monoclonal antibody production by CHO cells

(2010) Peter M. O'Callaghan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimised mammalian expression through the coupling of codon adaptation with gene amplification: Maximum yields with minimum effort

(2010) Ekaterini Kotsopoulou et al.   JOURNAL OF BIOTECHNOLOGY

Predicting cell-specific productivity from CHO gene expression

(2010) Colin Clarke et al.   JOURNAL OF BIOTECHNOLOGY

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Analysis and Prediction of the Metabolic Stability of Proteins Based on Their Sequential Features, Subcellular Locations and Interaction Networks

(2010) Tao Huang et al.   PLoS One

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Detection of discriminative sequence patterns in the neighborhood of proline cis peptide bonds and their functional annotation

(2009) Konstantinos P Exarchos et al.   BMC BIOINFORMATICS

Pseudo Amino Acid Composition and its Applications in Bioinformatics, Proteomics and System Biology

(2009) Kuo-Chen Chou   Current Proteomics

The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators

(2009) Nazzareno Dimasi et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

You're one in a googol: optimizing genes for protein expression

(2009) M. Welch et al.   Journal of the Royal Society Interface

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies

(2008) Christina J. Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Heterologous Protein Expression Is Enhanced by Harmonizing the Codon Usage Frequencies of the Target Gene with those of the Expression Host

(2008) Evelina Angov et al.   PLoS One

On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells

(2005) Stefan Schlatter et al.   BIOTECHNOLOGY PROGRESS