Article
Food Science & Technology
Fang Zhao, Xiaohan Zou, Shaoheng Li, Jing He, Chuchu Xi, Qinglian Tang, Yujing Wang, Zhengyu Cao
Summary: The research identified a new scorpion toxin, BmK NSPK, which enhances neurite extension through increasing the release of nerve growth factor and TrkA signaling pathway. This provides a new theoretical basis for developing treatments for spinal cord neuron development and regeneration using K-v channels.
Article
Multidisciplinary Sciences
PinFen Chua, William K. Lim
Summary: This study investigated the applications of different PC12 variants in neuroprotection research, identifying optimal culture conditions for PC12 Riken and NS-1 cells, and determining collagen IV as the preferred adhesive substrate for both cell lines. In the in vitro stroke model, NS-1 cells achieved a maximal differentiation of 72.7% after optimization, and the 5-HT1A agonist 8-OH-DPAT was found to be neuroprotective in PC12 cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Nessma Sultan, Laila E. Amin, Ahmed R. Zaher, Mohammed E. Grawish, Ben A. Scheven
Summary: Dental pulp stem cells secrete neurotrophic factors that significantly promote cell survival and neurite outgrowth in PC12 cells, with NGF, BDNF, and GDNF playing important roles. These factors may have potential therapeutic applications for peripheral nerve repair.
NEURAL REGENERATION RESEARCH
(2021)
Article
Engineering, Electrical & Electronic
Bjarke Norrehvedde Jensen, Yuting Wang, Alice Le Friec, Sadegh Nabavi, Mingdong Dong, Dror Seliktar, Menglin Chen
Summary: A wireless electromagnetic neural stimulation patch has been developed, which combines electromagnetic induction and physical guidance cues to promote neural cell growth and treat neurological diseases. In vitro experiments confirmed the biocompatibility and efficacy of the patch's electromagnetic stimulation in promoting neurite outgrowth, demonstrating its great potential for non-invasive neurological therapeutics.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Marta R. Casanova, Rui L. Reis, Albino Martins, Nuno M. Neves
Summary: A biofunctional electrospun fibrous mesh (eFM) was developed by selectively retrieving nerve growth factor (NGF) from rat blood plasma, which can enhance neurite outgrowth and promote neuronal differentiation for peripheral nerve injury.
Article
Chemistry, Multidisciplinary
Oana Dobre, Mariana A. G. Oliva, Giuseppe Ciccone, Sara Trujillo, Aleixandre Rodrigo-Navarro, Douglas Cormac Venters, Virginia Llopis-Hernandez, Massimo Vassalli, Cristina Gonzalez-Garcia, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: Laminins are crucial structural proteins in the ECM that bind growth factors and play tissue-specific roles. A new LM-PEG hydrogel platform inspired by Matrigel offers controlled stiffness and degradability, enabling specific targeting of tissues through GFs presented at ultralow doses. This platform demonstrates the potential to induce stem cell differentiation and promote neural cell growth in a synthetic, reproducible 3D microenvironment mimicking the native ECM.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Behavioral Sciences
Yutaka Gomita, Satoru Esumi, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Hirotoshi Motoda, Shigeki Inoue, Hiroaki Araki, Yoshio Kano
Summary: This study found that plasma from rats subjected to ICSS and IMM treatments promoted neurite outgrowth in PC12m12 cells, with different neuronal signal transduction pathways involved. By using neurotransmitter-sensitive cells, it may be possible to elucidate the pathogenesis of mental diseases and search for therapeutic drugs.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Valdemar B. I. Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y. Chu, Laraine Crossland, Hanneke Okkenhaug, Andrew J. Massey, David C. Hornigold, Heidi C. E. Welch, Stephen A. Chetwynd
Summary: Norbin is an adaptor protein that plays important roles in neuronal function and GPCR trafficking. This study provides new insights into the cellular functions of Norbin, showing that it regulates cell size, growth, and viability in PC12 cells. Additionally, Norbin controls the steady-state surface levels and agonist-induced internalisation of the GPCR S1PR1, suggesting it has a broader role in GPCR trafficking than previously thought. Furthermore, Norbin is involved in the activation of signaling pathways in PC12 cells. These findings enhance our understanding of the cellular functions of Norbin and its role in GPCR trafficking.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Gabrielle Edwards, Taaliah Campbell, Veronica Henderson, Alira Danaher, Daqing Wu, Rekha Srinivasan, Khosrow Rezvani, Valerie A. Odero-Marah
Summary: The study demonstrates that prostate cancer cells promote migration and adhesion to nerve cells through Snail expression, as well as neurite outgrowth via secretion of soluble factors. Targeting cancer cell interaction with nerves may be a potential strategy to halt prostate cancer progression/metastasis.
Article
Multidisciplinary Sciences
Anna-Kathrine Pedersen, Anamarija Pfeiffer, Gopal Karemore, Vyacheslav Akimov, Dorte B. Bekker-Jensen, Blagoy Blagoev, Chiara Francavilla, Jesper Olsen
Summary: This study investigated the roles of E3 ubiquitin ligases Cbl and Cbl-b in regulating signaling responses associated with neuroblastoma cell differentiation. By using mass spectrometry-based proteomics, the study identified SHP-2 and CDK16 as key regulators of extracellular signal-regulated kinase phosphorylation and neurite outgrowth in neuroblastoma, highlighting their involvement in the differentiation process.
Article
Biochemistry & Molecular Biology
Juliane Meissner, Maryam Rezaei, Isabel Siepe, Doreen Ackermann, Simone Koenig, Johannes A. Eble
Summary: Proteomics studies have shown that adhesomes are made up of a variety of proteins at cellular contact sites with the extracellular matrix. The redox state of individual adhesome proteins in response to environmental signals adds a new aspect to adhesome complexity. This redox proteomic analysis revealed that sulfenylation and protein location at adhesomes mutually influence each other.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yu Liu, Lili Zou, Peng Wang, Jingxuan Zhou, Chunling Yuan, Jun Wang
Summary: The study investigated the role of nerve growth factor (NGF) in neurogenesis of breast cancer cells, revealing its potential importance in regulating cancer-associated neurogenesis and affecting the migration, invasion, and metastasis abilities of tumor cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takeru Koga, Hideyuki Ito, Yuji Iwaoka, Toshiro Noshita, Akihiro Tai
Summary: Isorhamnetin-3-O-glucoside and astragalin, found in the petals of Paeonia lactiflora, were identified as compounds that promote neurite outgrowth. They showed strong activity and could potentially be used as functional food ingredients to prevent cognitive decline.
Article
Biochemistry & Molecular Biology
Nana Bie, Xiaojuan Feng, Chenjing Li, Meng Meng, Chunling Wang
Summary: DHA protects PC12 cells from oxidative damage induced by H2O2 by increasing antioxidant capacity, mitochondrial function, and phosphorylation levels of signaling proteins; it also promotes neurite outgrowth and regulates neurotransmitter levels.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri
Summary: This study investigates the different functions of ceramide in cellular differentiation and dedifferentiation. The results suggest that the function of ceramide heavily depends on its intracellular location, and further understanding of its function requires resolving its location during cellular status changes.
CELL COMMUNICATION AND SIGNALING
(2022)