Article
Engineering, Biomedical
Junyao Cheng, Hufei Wang, Jianpeng Gao, Xiao Liu, Ming Li, Decheng Wu, Jianheng Liu, Xing Wang, Zheng Wang, Peifu Tang
Summary: First-aid for severe traumatic injuries, especially skin defects or visceral rupture, remains a challenge. Hydrogel-based biomaterials have good biocompatibility but lack mechanical and bio-adhesion properties. A multifunctional hydrogel wound dressing is developed using dynamic covalent bonds, metal-catechol chelation, and hydrogen bonds. In vivo evaluation shows its effectiveness in hemostasis, antibacterial activity, and wound healing.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Polymer Science
Jie Liu, Wenqi Jiang, Qianyue Xu, Yongjie Zheng
Summary: Antibacterial hydrogel is widely used in biomedical, intelligent textiles, cosmetics, and other fields, especially in medical dressings. It has the characteristics of absorbing wound liquid, controlling drug release, and its preparation method is simple with easily accessible materials.
Article
Biotechnology & Applied Microbiology
Feng Wang, Shuguang Wang, Liping Nan, Jiawei Lu, Ziqi Zhu, Jintao Yang, Dong Zhang, Junjian Liu, Xiao Zhao, Desheng Wu
Summary: Wound injuries can lead to serious consequences, and the use of biomedical hydrogels as wound dressings has shown great potential in accelerating wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengmeng Xie, Yanbo Zeng, Hang Wu, Shige Wang, Jiulong Zhao
Summary: A multifunctional hydrogel has been developed that can rapidly stop bleeding and has antibacterial properties, promoting wound healing and repair. The hydrogel has good water retention capacity and mimics the three-dimensional structure of the natural extracellular matrix, making it promising for applications in hemostasis and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zheng Chen, Jinpeng Yao, Jiulong Zhao, Shige Wang
Summary: In this study, a multifunctional COP hydrogel composed of CMCS, OD, and γ-PGA was prepared for antimicrobial and hemostasis of diffuse wounds. The COP hydrogel exhibited significant antibacterial effects, inhibited bacterial growth, and promoted wound healing. It also showed superior hemostasis ability in a rat tail diffuse hemorrhage wound model. Therefore, the multifunctional COP hydrogel is expected to have important applications in wound hemostasis and healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Yun Zhu, Li Liu, Shaoqing Chen, Dan Han, Cheng Wang
Summary: Wound infection, especially chronic ones, can lead to the emergence of antibiotic-resistant bacteria and cause physical and mental burden on patients. This study developed an agarose-hyaluronic acid hydrogel that could potentially serve as an antibacterial wound dressing, promoting healing while maintaining antibacterial efficacy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charles Brooker, Giuseppe Tronci
Summary: In this study, a theranostic dressing was developed by integrating a collagen-based wound contact layer with a halochromic dye that undergoes a color change in response to infection-associated pH changes. Two different integration strategies, drop-casting and electrospinning, were utilized to introduce long-lasting visual infection detection capability. The results showed that the drop-cast samples retained a higher percentage of the dye compared to the fiber-bearing prototypes, suggesting the potential of this design for accelerated wound healing and prompt infection diagnosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Tian Hu, Guan-Ping Wu, Huaitian Bu, Hongyan Zhang, Wei-Xiong Li, Kui Song, Gang-Biao Jiang
Summary: In this study, an injectable multifunctional hydrogel incorporating fusiform-like zinc oxide nanorods into carboxymethyl chitosan was synthesized. The hydrogel exhibited quick self-healing, good tissue adhesion, and fast hemostasis capabilities. Additionally, it demonstrated excellent antibacterial properties. In a full-thickness skin defect experiment, the hydrogel fit well to the wound geometries and released antibacterial zinc ions slowly and sustainably, promoting wound healing and reducing inflammation significantly.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Xianhua Xie, Xin Jin, Binbin He, Yang Zou, Jumin Yang, Changjun Liu, Xiaoling Kong, Wenguang Liu, Wei Wang
Summary: This report introduces a hydrogel dressing with antibacterial and anti-inflammatory activities designed for diabetic wounds. The dressing is formed through in situ crosslinking of gelatin methacrylate and a hyperbranched terpolymer, and it exhibits strong antimicrobial and anti-inflammatory properties.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Environmental
Yuxin Zhang, Can Wu, Yuanyuan Xu, Zhiyu Chen, Lei Li, Jiali Chen, Ning Ning, Yi Guo, Zeyu Yang, Xuefeng Hu, Jieyu Zhang, Yunbing Wang
Summary: In this study, advanced hydrogels with stable conductivity and effective antibacterial properties were developed by incorporating antibacterial terbium ions into the hydrogel network. The hydrogel showed tremendous antibacterial effects and biomimetic conductivity, which enabled electrical stimulation (ES) treatment for diabetic ulcers (DUs) and accelerated wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Qian Pang, Kaihao Wu, Zilian Jiang, Zewen Shi, Zizhen Si, Qiang Wang, Yuhao Cao, Ruixia Hou, Yabin Zhu
Summary: A novel photothermal antibacterial agent, double bonds-ended polyaniline nanoparticle (Me-PANI NP), was synthesized and incorporated into a hydrogel wound dressing, providing controllable photothermal antibacterial treatment and improved mechanical flexibility. This development has the potential to advance wound healing and infection control in a more effective and efficient manner.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Xiaoyu Wang, Rijian Song, Melissa Johnson, Zhonglei He, Cameron Milne, Xianqing Wang, Irene Lara-Saez, Qian Xu, Wenxin Wang
Summary: Chitosan-based hydrogels have great potential in regenerative medicine for applications such as bacteriostasis, hemostasis, and wound healing, but toxicity and high cost are issues that need to be addressed. This study developed a biocompatible and cost-effective chitosan-based hydrogel system for wound healing, showing excellent antibacterial activity and biocompatibility. The results indicate that the newly designed chitosan-based hydrogel is a promising antibacterial wound dressing candidate.
Article
Chemistry, Applied
Fengling Liu, Lu Wang, Xinrang Zhai, Shunxian Ji, Jingjia Ye, Zhiqiang Zhu, Chong Teng, Wei Dong, Wei Wei
Summary: In this study, a multi-functional chitosan hydrogel was designed by combining chitosan methacrylate and sulfhydrated chitosan and cross-linking them through two reactions. The resulting hydrogel exhibited superior tissue adhesive properties, mechanical properties, and antimicrobial effects. Furthermore, it showed good biocompatibility and promoted skin repair in both cell experiments and animal experiments.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Yunyun Wei, Ziqiang Han, Xiaolong Mao
Summary: A living probiotic dressing was constructed using droplet-shearing and photo-cross-linking technologies to effectively treat infected wounds and promote wound healing. The dressing demonstrated superior biosafety, inhibiting bacterial survival and colonization, reducing inflammation, and accelerating wound closure. This work provides new ideas for clinical wound treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)