Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks

The use of rice seeds to produce human pharmaceuticals for oral therapy

(2013) Yuhya Wakasa et al.   Biotechnology Journal

Seeds as a Production System for Molecular Pharming Applications: Status and Prospects

(2013) Maite Sabalza et al.   CURRENT PHARMACEUTICAL DESIGN

Target Product Selection - Where Can Molecular Pharming Make the Difference?

(2013) Mathew Paul et al.   CURRENT PHARMACEUTICAL DESIGN

Optimizing the Yield of Recombinant Pharmaceutical Proteins in Plants

(2013) Richard Twyman et al.   CURRENT PHARMACEUTICAL DESIGN

Commercial Aspects of Pharmaceutical Protein Production in Plants

(2013) Rainer Fischer et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell and Tissue Cultures

(2013) Stefan Schillberg et al.   CURRENT PHARMACEUTICAL DESIGN

Subcellular Accumulation and Modification of Pharmaceutical Proteins in Different Plant Tissues

(2013) Anna Hofbauer et al.   CURRENT PHARMACEUTICAL DESIGN

Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

(2013) Alexandra Castilho et al.   PLoS One

Paradoxical EU agricultural policies on genetically engineered crops

(2013) Gemma Masip et al.   TRENDS IN PLANT SCIENCE

Predictive models for transient protein expression in tobacco (Nicotiana tabacum L.) can optimize process time, yield, and downstream costs

(2012) J.F. Buyel et al.   BIOTECHNOLOGY AND BIOENGINEERING

The use of plants for the production of therapeutic human peptides

(2012) Chiara Lico et al.   PLANT CELL REPORTS

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

(2012) M. Sabalza et al.   PLANT MOLECULAR BIOLOGY

Toward Stable Genetic Engineering of Human O-Glycosylation in Plants

(2012) Z. Yang et al.   PLANT PHYSIOLOGY

Engineering of human-type O-glycosylation inNicotiana benthamianaplants

(2012) Richard Strasser   Bioengineered

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies

(2011) Jenny Peters et al.   Human vaccines & immunotherapeutics

EU legitimizes GM crop exclusion zones

(2011) Maite Sabalza et al.   NATURE BIOTECHNOLOGY

Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants

(2011) G. Parra et al.   NUCLEIC ACIDS RESEARCH

Protein body-inducing fusions for high-level production and purification of recombinant proteins in plants

(2011) Andrew J. Conley et al.   PLANT BIOTECHNOLOGY JOURNAL

Nutritionally enhanced crops and food security: scientific achievements versus political expediency

(2010) Gemma Farre et al.   CURRENT OPINION IN BIOTECHNOLOGY

Purification of recombinant plant-made proteins from corn extracts by ultrafiltration

(2010) Matthew T. Aspelund et al.   JOURNAL OF MEMBRANE SCIENCE

Going to ridiculous lengths—European coexistence regulations for GM crops

(2010) Koreen Ramessar et al.   NATURE BIOTECHNOLOGY

Dispensable Dicer

(2010) Arianne Heinrichs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Seed-based expression systems for plant molecular farming

(2010) Joseph Boothe et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression and recovery of biologically active recombinant Apolipoprotein AIMilano from transgenic safflower (Carthamus tinctorius) seeds

(2010) Cory L. Nykiforuk et al.   PLANT BIOTECHNOLOGY JOURNAL

Promoter diversity in multigene transformation

(2010) Ariadna Peremarti et al.   PLANT MOLECULAR BIOLOGY

Plants as bioreactors: Recent developments and emerging opportunities

(2009) Arun K. Sharma et al.   BIOTECHNOLOGY ADVANCES

Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

(2009) Reynald Tremblay et al.   BIOTECHNOLOGY ADVANCES

Force Majeure: Therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease

(2009) Carla E.M. Hollak et al.   BLOOD CELLS MOLECULES AND DISEASES

Design, expression, and characterization of a multivalent, combination HIV microbicide

(2009) Amy Sexton et al.   FASEB JOURNAL

Microbial factories for recombinant pharmaceuticals

(2009) Neus Ferrer-Miralles et al.   Microbial Cell Factories

8. Novel enzyme replacement therapy for Gaucher disease: Ongoing Phase III clinical trial with recombinant human glucocerebrosidase expressed in plant cells

(2009) David Aviezer et al.   MOLECULAR GENETICS AND METABOLISM

A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation

(2009) David Aviezer et al.   PLoS One

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

(2009) S. Naqvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When more is better: multigene engineering in plants

(2009) Shaista Naqvi et al.   TRENDS IN PLANT SCIENCE

Gene expression enhancement mediated by the 5′ UTR intron of the rice rubi3 gene varied remarkably among tissues in transgenic rice plants

(2008) Jianli Lu et al.   MOLECULAR GENETICS AND GENOMICS

Trace and traceability—a call for regulatory harmony

(2008) Koreen Ramessar et al.   NATURE BIOTECHNOLOGY

Molecular pharming in cereal crops

(2008) Koreen Ramessar et al.   PHYTOCHEMISTRY REVIEWS

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission

(2008) K. Ramessar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants

(2008) Armin Spök et al.   TRENDS IN BIOTECHNOLOGY