期刊
BIOTECHNOLOGY LETTERS
卷 35, 期 10, 页码 1707-1714出版社
SPRINGER
DOI: 10.1007/s10529-013-1242-2
关键词
Antioxidant; Mesenchymal stem cell; Photoaging; Serum-free medium
资金
- Guangdong International Project [2010B050100022]
- Guangdong University Scientific and Technological Achievements of Major Projects [cgzhzd0905]
- Fundamental Research Funds for the Central University in R. P. China [21612330]
Chronic exposure to solar radiation is the primary cause of photoaging and benign and malignant skin tumors. A conditioned serum-free medium (SFM) was prepared from umbilical cord mesenchymal stem cells (UC-MSCs) and its anti-photoaging effect, following chronic UV irradiation in vitro and in vivo, was evaluated. UC-MSC SFM had a stimulatory effect on human dermal fibroblast proliferation and reduced UVA-induced cell death. In addition, UC-MSC SFM blocked UVA inhibition of superoxide dismutase activity. Topical application of UC-MSC SFM to mouse skin prior to UV irradiation blocked the inhibition of superoxide dismutase and glutathione peroxidase activities, and prevented the upregulation of malonaldehyde. UC-MSC SFM thus protects against photoaging induced by UVA and UVB radiation and is a promising candidate for skin anti-photoaging treatments.
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