Systems metabolic engineering for the production of bio-nylon precursor

Systematic approaches for in silico design of metabolic pathways and experimental evaluation of cellular performance are important for the development of industrially useful organisms. In this issue of Biotechnology Journal, Buschke et al. [1] report the production of 1,5-diaminopentane using xylose produced by Corynebacterium glutamicum by employing integration methodologies of rational design for genetic improvement, experimental analysis of metabolic fluxes, and comprehensive gene expression.