期刊
BIOTECHNOLOGY JOURNAL
卷 7, 期 10, 页码 1216-1220出版社
WILEY-BLACKWELL
DOI: 10.1002/biot.201200136
关键词
DBC; Downstream Processing; Biochromatography; Bioseparation; Protein adsorption
资金
- NSF [CBET-1032727]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1032727] Funding Source: National Science Foundation
The dynamic binding capacity (DBC) and its dependence on residence time influence the design and productivity of adsorption columns used in protein capture applications. This paper offers a very simple approach to predict the DBC of an adsorption column based on a measurement of the equilibrium binding capacity (EBC) and of the time needed to achieve one-half of the EBC in a batch adsorption test. The approach is based on a mass transfer kinetics model that assumes pore diffusion with a rectangular isotherm; however, the same approach is also shown to work for other systems where solute transport inside the particle occurs through other transport mechanisms.
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