Article
Chemistry, Multidisciplinary
Lu Liu, Qing Liu, Rong Li, Ming-Sheng Wang, Guo-Cong Guo
Summary: A unique method was used to generate a partially charge separated state with a long lifetime during the decay of excited states for viologen analogues, which is significant for photochromic compounds and other applications. The findings shed light on the relaxation processes of excited states and offer a potential design strategy for multicolor photochromism and efficient light-energy conversion.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Alexander M. Mintairov, Dmitrii Lebedev, Alexei S. Vlasov, Alexei O. Orlov, Gregory L. Snider, Steven A. Blundell
Summary: The proposal for fault-tolerant quantum computations is based on topological quantum field theories, relying on the existence of physical systems with non-Abelian topological terms. Overcoming obstacles in implementing these operations in potential material systems is crucial, and the novel system presented in the research shows promise for advancing the realization of topological quantum computing.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Dmitry B. Eremin, Valery V. Fokin
Summary: Supercharging reagents can enhance protein ionization by increasing charge states and signal intensities, leading to improved sensitivity. This study presents a method of utilizing a dual-spray ionization source with DMSO as a supercharging reagent to expand in-source supercharging.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemical Research Methods
Marius M. Kostelic, Chih-Chieh Hsieh, Henry M. Sanders, Ciara K. Zak, Jack P. Ryan, Erin S. Baker, Craig A. Aspinwall, Michael T. Marty
Summary: Native mass spectrometry and charge detection-mass spectrometry are versatile tools for characterizing proteins and macromolecular complexes. Researchers have improved sensitivity by modifying the surface of nanoelectrospray ionization needles with inert surface modifiers.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Chemistry, Physical
Anjali, Nand Kishore
Summary: The study investigated the effects of different amino acids on the stability of the partially folded state of bovine serum albumin at pH 11.2. Results showed that, except for L-leucine and L-valine, other amino acids could enhance its thermal stability. Spectroscopic and calorimetric observations combined enabled monitoring amino acid-induced conformational changes.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Physics, Multidisciplinary
N. A. Poklonski, I. I. Anikeev, S. A. Vyrko
Summary: This research theoretically studies the DC hopping photoconductivity caused by the migration of electrons via intrinsic point t-defects of the same type with three charge states (-1, 0, and +1). The study assumes that t-defects are randomly distributed over a crystal and hops of single electrons occur only via t-defects in the charge states (-1), (0), and (0), (+1). Under intercenter illumination, nonequilibrium charge states (-1) and (+1) of defects are generated, which leads to a negative DC photoconduction. The research provides insights into the relationship between photoconductivity and dark hopping electrical conductivity.
Article
Metallurgy & Metallurgical Engineering
A. A. Emel'yanov, S. M. Gaidar, T. I. Bal'kova, A. M. Pikina
Summary: This article examines the impact of different ratios of corrosion inhibitors in a steel-organic surfactant-electrolyte system on changes in the total quantity of electric charge over time. Approximation equations are derived to calculate the slow adsorption surface electronic states of the interface for each inhibitor system. The synergistic effect of the inhibitors is demonstrated.
RUSSIAN METALLURGY
(2023)
Article
Chemistry, Multidisciplinary
Chiara Capitani, Valerio Pinchetti, Graziella Gariano, Beatriz Santiago-Gonzalez, Carlo Santambrogio, Marcello Campione, Mirko Prato, Rosaria Brescia, Andrea Camellini, Fulvio Bellato, Francesco Carulli, Abhinav Anand, Margherita Zavelani-Rossi, Francesco Meinardi, Scott A. Crooker, Sergio Brovelli
Article
Biochemical Research Methods
Marco Mangiagalli, Stefania Brocca, Marco Orlando, Marina Lotti
Article
Biochemistry & Molecular Biology
Roberta Corti, Claudia A. Marrano, Domenico Salerno, Stefania Brocca, Antonino Natalello, Carlo Santambrogio, Giuseppe Legname, Francesco Mantegazza, Rita Grandori, Valeria Cassina
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Marco Mangiagalli, Michela Lapi, Serena Maione, Marco Orlando, Stefania Brocca, Alessandra Pesce, Alberto Barbiroli, Carlo Camilloni, Sandra Pucciarelli, Marina Lotti, Marco Nardini
Summary: Psychrophilic organisms produce enzymes with high specific activity at low temperatures to adapt to cold environments. The GH42 beta-galactosidase from Marinomonas ef1 exhibits cold activity and robustness, possibly evolving from a thermostable scaffold. Its unique hexameric arrangement and large central cavity contribute to substrate accessibility, with a peculiar cooperative behavior likely related to internal cavity permeability increase triggered by heating. These findings challenge the traditional view of cold activity coupled with intrinsic thermolability.
Article
Biochemistry & Molecular Biology
Cristina Visentin, Luca Broggini, Benedetta Maria Sala, Rosaria Russo, Alberto Barbiroli, Carlo Santambrogio, Simona Nonnis, Anatoly Dubnovitsky, Martino Bolognesi, Elena Miranda, Adnane Achour, Stefano Ricagno
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Ivan Orlandi, Lilia Alberghina, Marina Vai
Review
Biochemistry & Molecular Biology
Greta Bianchi, Sonia Longhi, Rita Grandori, Stefania Brocca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Stefania Brocca, Rita Grandori, Sonia Longhi, Vladimir Uversky
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Arianna Luise, Elena De Cecco, Erika Ponzini, Martina Sollazzo, PierLuigi Mauri, Frank Sobott, Giuseppe Legname, Rita Grandori, Carlo Santambrogio
Summary: Post-translational modifications can lead to diverse functional roles for a single protein, with oxidation being a common modification. Analyzing the interaction of proteins with dopamine and characterizing the proteoforms generated by dopamine-induced oxidation through top-down fragmentation can provide insights into the structural changes and relative abundance of different protein states.
Article
Biochemistry & Molecular Biology
Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca
Summary: This study investigates the effects of charge patterning on the average compactness and shape of three model IDPs with different proline content. The results show that charge clustering induces remodeling of the conformational ensemble, promoting compaction and/or increasing spherical shape. Additionally, the shape and volume of the ensembles depend on other factors such as charge distribution.
Article
Biochemistry & Molecular Biology
Greta Bianchi, Stefania Brocca, Sonia Longhi, Vladimir N. Uversky
Summary: Liquid-liquid phase separation (LLPS) plays an important role in the formation of membrane-less organelles (MLOs) in cells. Intrinsically disordered proteins (IDPs) or regions (IDRs) together with nucleic acids are involved in the formation of these cellular condensates. Viral proteins also exploit LLPS to form viral replication compartments and partition into cellular MLOs. This study focuses on a group of eukaryotic proteins that are sequestered in viral factories or colocalize with viral proteins in cellular MLOs, aiming to gather information on their disorder content, LLPS propensity, and biological functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Prakash Kulkarni, Stefania Brocca, A. Keith Dunker, Sonia Longhi
Review
Biochemistry & Molecular Biology
Lilia Alberghina
Summary: The Warburg effect and its yeast counterpart, the Crabtree effect, have long been a mystery in cancer biology. This study presents a new working hypothesis that explains how enhanced glycolysis can provide a growth advantage to cancer cells. By constructing metabolic maps, this hypothesis contributes to a better understanding of cancer biology and identifies new directions for the development of more efficient metabolism-targeted anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Erika Ponzini, Diletta Ami, Alessandro Duse, Carlo Santambrogio, Antonella De Palma, Dario Di Silvestre, Pierluigi Mauri, Fabio Pezzoli, Antonino Natalello, Silvia Tavazzi, Rita Grandori
Summary: This study developed an analytical pipeline for single-tear analysis by ultrahigh-resolution, shotgun proteomics and identified a total of 890 proteins from healthy human volunteers. The study found that proteins in tears can be classified based on gender, and samples collected at different times of the day show differences in protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
