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Pharmacology & Pharmacy
Ying Wang, Guan-An Zhao, Xia Li, En Zhang, Wei Tan, Jia-qi Chen
Summary: A fast, simple, and sensitive UPLC-MS/MS method was established for the quantification of safinamide in rat plasma. The method showed high stability, low noise, short chromatographic run time, wide linear range, small sample and injection volumes, and high sensitivity, making it suitable for pharmacokinetics and preclinical and clinical studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Qiang You, Dan Li, Haiyan Ding, Hongping Chen, Yuan Hu, Youping Liu
Summary: Polymethoxyflavones (PMFs) are a subgroup of flavonoids with various health benefits. The number and position of hydroxy and methoxy groups play an important role in modulating the pharmacokinetics and metabolites of PMFs, with hydroxy-containing PMFs generally more cytotoxic than those without hydroxy groups.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yunyun Zhan, Anzhou Wang, Yige Yu, Jie Chen, Xinhao Xu, Jingjing Nie, Jingjing Lin
Summary: This paper investigates the inhibitory effect of vortioxetine on cytochrome P450 and the type of inhibitory mechanism in human and rat liver microsomes. It reveals different types of inhibition in human and rat models and provides guidance for safe clinical use.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Meiling Zhang, Lvqi Luo, Xiangyi Dai, Yifan He, Jianshe Ma
Summary: This study investigated the pharmacokinetic differences of oleandrin and adynerin in rats and found variations in their bioavailability.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xuegu Xu, Chaojie Chen, Ya-nan Liu, Xiaolei Meng, Jian-ping Cai, Ren-ai Xu
Summary: This study optimized an analytical method using UPLC-MS/MS for the determination of Infigratinib concentrations in rat plasma and pharmacokinetic studies. The method demonstrated high linearity and accuracy, with good reproducibility and rapidity.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemical Research Methods
Congyang Ding, Caihui Guo, Lingzhi Fang, Yajing Li, Zhi Wang, Zhanjun Dong
Summary: In this study, male Sprague-Dawley rats were administered with ASIV and VER to study their pharmacokinetics. The results showed that ASIV did not significantly alter the main parameters of VER, except for a 33.2% decrease in C-max. A selective, sensitive, and repeatable UPLC-MS/MS analysis was successfully established for detecting VER in rat plasma.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Xinrui Wang, Jianzhong Lu, Guotong Li, Lifei Luo, Zhen Yuan, Min Li, Jingze Zhang, Dailin Liu
Summary: Taohong Siwu Decoction (THSWD) is a classic recipe in China, used to nourish and activate blood. Previous studies have shown that THSWD has antioxidant, anti-inflammatory, anti-platelet aggregation, and lipid-lowering effects, as well as the ability to improve hemorheological changes and regulate signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xuegu Xu, Shunbin Luo, Qiang Yang, Yingjie Wang, Wenlong Li, Guanyang Lin, Ren-ai Xu
Summary: An advanced UPLC-MS/MS method was developed to determine avapritinib concentration in rat plasma, demonstrating good linearity and a lower limit of quantification suitable for pharmacokinetic studies. The method involved the addition of acetonitrile and a gradient elution procedure, with reliable precision and accuracy for avapritinib analysis.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ying Zhang, Mengxiao Zhu, Saili Xie, Xuemei Ye, Xuegu Xu
Summary: The experiment established a method for analyzing specific drug concentrations and metabolites in rat plasma, and studied their pharmacokinetic characteristics. The method showed good linearity, sensitivity, and accuracy, suitable for determining pharmacokinetic parameters of specific drugs in rats.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu, Zhanjun Dong
Summary: A method for simultaneous determination of lenvatinib and telmisartan was developed in this study, showing that lenvatinib decreased the systemic exposure of telmisartan. Potential drug interactions were observed between lenvatinib and telmisartan.
Article
Chemistry, Analytical
Jianshe Ma, Xianqin Wang
Summary: In this study, UPLC-MS/MS was used to determine the concentration of 8-deacetyl-yunaconitine in rat plasma after oral and intravenous administration. The pharmacokinetics of the drug showed differences between intravenous and oral administration, with a quick metabolism observed in rats.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Chunling Zhou, Aiping He, Qiang Kang, Chensen Li, Tianzhu Liu, Wenting Cai, Lina Fang, Shuangcheng Ma
Summary: The aim of this study was to establish and validate a simple and sensitive UPLC-MS/MS method for determining the concentration of UNC1999 in plasma samples. The method showed good linearity, accuracy, and precision, and allowed for the characterization of the pharmacokinetic profile of UNC1999 in rats.
Article
Chemistry, Analytical
Yanjun Cui, Ying Li, Liju Fan, Jing An, Xiaonan Wang, Ran Fu, Zhanjun Dong
Summary: The combination of traditional Chinese medicine preparation Wuzhi capsule (WZC) and multitargeted tyrosine kinase inhibitor Lenvatinib (LEN) may impact the pharmacokinetic parameters of LEN in rats and increase the plasma concentration of LEN. An UPLC-MS/MS method developed in this study serves as a valuable tool for studying drug-drug interactions.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Er-Min Gu, Ya-Nan Liu, Lvjun Pan, Yingying Hu, Xuemei Ye, Pingping Luo
Summary: This study developed a high throughput method to quantify sorafenib, regorafenib, cabozantinib and their active metabolites in plasma simultaneously. The method showed good specificity, precision, and accuracy, and was successfully applied to pharmacokinetic study.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Hongli Mu, Wenyu Zhang, Yuanming Song, Rui Liang, Hengli Zhao, Chunhong Song, Qing Wen
Summary: An ultra-performance liquid chromatography-tandem mass spectrometry method was developed for the determination of baloxavir acid (BXA) and baloxavir marboxil (BXM) concentrations, as well as for studying the pharmacokinetics of BXA. The method showed good linearity and accuracy, with a lower limit of quantification of 3.00 ng/mL. This method is suitable for clinical research on BXA determination and pharmacokinetic studies.
BIOMEDICAL CHROMATOGRAPHY
(2023)