Systems metabolic engineering design: Fatty acid production as an emerging case study

Free fatty acid production in Escherichia coli under phosphate-limited conditions

(2013) J. Tyler Youngquist et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improvement of free fatty acid production in Escherichia coli using codon-optimized Streptococcus pyogenes acyl-ACP thioesterase

(2013) Sunhee Lee et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Central metabolic responses to the overproduction of fatty acids inEscherichia colibased on13C-metabolic flux analysis

(2013) Lian He et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microbial production of short-chain alkanes

(2013) Yong Jun Choi et al.   NATURE

Tailored fatty acid synthesis via dynamic control of fatty acid elongation

(2013) J. P. Torella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Heterologous Co-expression of accA, fabD, and Thioesterase Genes for Improving Long-Chain Fatty Acid Production in Pseudomonas aeruginosa and Escherichia coli

(2012) Sunhee Lee et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Boosting the free fatty acid synthesis of Escherichia coli by expression of a cytosolic Acinetobacter baylyi thioesterase

(2012) Yanning Zheng et al.   Biotechnology for Biofuels

An integrated computational environment for elementary modes analysis of biochemical networks

(2012) Paulo Maia et al.   International Journal of Data Mining and Bioinformatics

Effect of acetate formation pathway and long chain fatty acid CoA-ligase on the free fatty acid production in E. coli expressing acy-ACP thioesterase from Ricinus communis

(2012) Mai Li et al.   METABOLIC ENGINEERING

Enhancing fatty acid production by the expression of the regulatory transcription factor FadR

(2012) Fuzhong Zhang et al.   METABOLIC ENGINEERING

An integrated computational and experimental study for overproducing fatty acids in Escherichia coli

(2012) Sridhar Ranganathan et al.   METABOLIC ENGINEERING

Analysis of omics data with genome-scale models of metabolism

(2012) Daniel R. Hyduke et al.   Molecular BioSystems

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Escherichia coli for biofuel production: bridging the gap from promise to practice

(2012) Sarah Huffer et al.   TRENDS IN BIOTECHNOLOGY

Engineering Escherichia coli to synthesize free fatty acids

(2012) Rebecca M. Lennen et al.   TRENDS IN BIOTECHNOLOGY

A Synthetic Biology Approach to Engineer a Functional Reversal of the β-Oxidation Cycle

(2012) James M. Clomburg et al.   ACS Synthetic Biology

Membrane Stresses Induced by Overproduction of Free Fatty Acids in Escherichia coli

(2011) Rebecca M. Lennen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of fatty acid biosynthesis by engineered recombinant Escherichia coli

(2011) Sunhee Lee et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Improving fatty acid production in escherichia coli through the overexpression of malonyl coA-Acyl carrier protein transacylase

(2011) Xiujun Zhang et al.   BIOTECHNOLOGY PROGRESS

Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity

(2011) Fuyuan Jing et al.   BMC BIOCHEMISTRY

Metabolic engineering of microbial pathways for advanced biofuels production

(2011) Fuzhong Zhang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Efficient free fatty acid production in Escherichia coli using plant acyl-ACP thioesterases

(2011) Xiujun Zhang et al.   METABOLIC ENGINEERING

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA

(2011) Peng Xu et al.   METABOLIC ENGINEERING

EMILiO: A fast algorithm for genome-scale strain design

(2011) Laurence Yang et al.   METABOLIC ENGINEERING

Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

(2011) Clementina Dellomonaco et al.   NATURE

Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

(2011) Joonhoon Kim et al.   PLoS One

In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli

(2011) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems metabolic engineering for chemicals and materials

(2011) Jeong Wook Lee et al.   TRENDS IN BIOTECHNOLOGY

Genetic Engineering ofEscherichia colifor Biofuel Production

(2010) Tiangang Liu et al.   Annual Review of Genetics

A process for microbial hydrocarbon synthesis: Overproduction of fatty acids inEscherichia coliand catalytic conversion to alkanes

(2010) Rebecca M. Lennen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantitative analysis and engineering of fatty acid biosynthesis in E. coli

(2010) Tiangang Liu et al.   METABOLIC ENGINEERING

Application and engineering of fatty acid biosynthesis in Escherichia coli for advanced fuels and chemicals

(2010) Paul Handke et al.   METABOLIC ENGINEERING

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

(2010) Eric J. Steen et al.   NATURE

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

(2010) Sridhar Ranganathan et al.   PLoS Computational Biology

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

(2009) Z. L. Fowler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Political, economic and environmental impacts of biofuels: A review

(2009) Ayhan Demirbas   APPLIED ENERGY

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

(2009) Mohammad A. Asadollahi et al.   METABOLIC ENGINEERING

Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli

(2008) Markus W. Covert et al.   BIOINFORMATICS

Overproduction of free fatty acids in E. coli: Implications for biodiesel production

(2008) Xuefeng Lu et al.   METABOLIC ENGINEERING