Insulin receptor antibody-iduronate 2-sulfatase fusion protein: Pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

Blood-Brain Barrier Molecular Trojan Horse Enables Imaging of Brain Uptake of Radioiodinated Recombinant Protein in the Rhesus Monkey

(2013) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

(2013) J. A. Couch et al.   Science Translational Medicine

IgG-Enzyme Fusion Protein: Pharmacokinetics and Anti-Drug Antibody Response in Rhesus Monkeys

(2012) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies

(2012) Qing-Hui Zhou et al.   JOURNAL OF DRUG TARGETING

Evaluation of idursulfase for the treatment of mucopolysaccharidosis II (Hunter syndrome)

(2012) Maurizio Scarpa   Expert Opinion on Orphan Drugs

Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein

(2011) Jeff Zhiqiang Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys

(2011) Brian R. Felice et al.   TOXICOLOGIC PATHOLOGY

Genetic Engineering of a Bifunctional IgG Fusion Protein with Iduronate-2-Sulfatase

(2009) Jeff Zhiqiang Lu et al.   BIOCONJUGATE CHEMISTRY

AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

(2009) Ruben J. Boado et al.   JOURNAL OF BIOTECHNOLOGY

Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery

(2009) William M. Pardridge et al.   PHARMACEUTICAL RESEARCH

Neurological findings in Hunter disease: Pathology and possible therapeutic effects reviewed

(2008) S. Al Sawaf et al.   JOURNAL OF INHERITED METABOLIC DISEASE