Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

Functional heterogeneity and heritability in CHO cell populations

(2012) Sarah L. Davies et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in chinese hamster ovary cells

(2012) Megan Mason et al.   BIOTECHNOLOGY PROGRESS

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

(2011) Minsoo Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

(2011) Sarah L. Davies et al.   BIOTECHNOLOGY PROGRESS

In VivoCrystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells

(2011) Haruki Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A simple high-yielding process for transient gene expression in CHO cells

(2011) Yashas Rajendra et al.   JOURNAL OF BIOTECHNOLOGY

Engineering a mammalian super producer

(2011) Stefanie Dietmair et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell line-specific control of recombinant monoclonal antibody production by CHO cells

(2010) Peter M. O'Callaghan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimised mammalian expression through the coupling of codon adaptation with gene amplification: Maximum yields with minimum effort

(2010) Ekaterini Kotsopoulou et al.   JOURNAL OF BIOTECHNOLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Cyclosporine A-Sensitive, Cyclophilin B-Dependent Endoplasmic Reticulum-Associated Degradation

(2010) Riccardo Bernasconi et al.   PLoS One

Synthetic design of strong promoters

(2010) M. R. Schlabach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plasmid-based multigene expression system for mammalian cells

(2010) Andrijana Kriz et al.   Nature Communications

High-level protein expression in scalable CHO transient transfection

(2009) Jianxin Ye et al.   BIOTECHNOLOGY AND BIOENGINEERING

Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells

(2009) Lore Florin et al.   JOURNAL OF BIOTECHNOLOGY

The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators

(2009) Nazzareno Dimasi et al.   JOURNAL OF MOLECULAR BIOLOGY

How antibodies fold

(2009) Matthias J. Feige et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

(2008) Ren-Wang Peng et al.   BIOTECHNOLOGY AND BIOENGINEERING

A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies

(2008) Christina J. Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

THE COST BURDEN OF TRASTUZUMAB AND BEVACIZUMAB THERAPY FOR SOLID TUMOURS IN CANADA

(2008) Arik Drucker   Current Oncology

Rationalizing translation attenuation in the network architecture of the unfolded protein response

(2008) A. Trusina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

(2007) Stephen J. Wilkinson et al.   Molecular BioSystems

On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells

(2005) Stefan Schlatter et al.   BIOTECHNOLOGY PROGRESS