The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

(2011) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Economic comparison of diagnostic antibody production in perfusion stirred tank and in hollow fiber bioreactor processes

(2011) Raisa Vermasvuori et al.   BIOTECHNOLOGY PROGRESS

Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

(2011) Paula Meleady et al.   BMC BIOTECHNOLOGY

Separation science is the key to successful biopharmaceuticals

(2011) Georges Guiochon et al.   JOURNAL OF CHROMATOGRAPHY A

Antibody capture by mixed-mode chromatography: A comprehensive study from determination of optimal purification conditions to identification of contaminating host cell proteins

(2011) Jerome Pezzini et al.   JOURNAL OF CHROMATOGRAPHY A

Advances in the production and downstream processing of antibodies

(2011) John H. Chon et al.   New Biotechnology

Modeling industrial centrifugation of mammalian cell culture using a capillary based scale-down system

(2010) Matthew Westoby et al.   BIOTECHNOLOGY AND BIOENGINEERING

Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody

(2010) Julita K. Grzeskowiak et al.   ELECTROPHORESIS

Recent advances in large-scale production of monoclonal antibodies and related proteins

(2010) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Ultra scale-down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths

(2009) A.S. Tait et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell proteins in biologics development: Identification, quantitation and risk assessment

(2009) Xing Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cells

(2009) Lyne Jossé et al.   BIOTECHNOLOGY AND BIOENGINEERING

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

(2009) Mi Jin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Use of proteomics for design of a tailored host cell for highly efficient protein purification

(2009) Zhu Liu et al.   JOURNAL OF CHROMATOGRAPHY A

2-D DIGE to expedite downstream process development for human monoclonal antibody purification

(2009) Julita K. Grzeskowiak et al.   PROTEIN EXPRESSION AND PURIFICATION

Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates

(2008) Emma J. Mead et al.   BIOTECHNOLOGY AND BIOENGINEERING

Ultra Scale-Down To Define and Improve the Relationship between Flocculation and Disc-Stack Centrifugation

(2008) A. Berrill et al.   BIOTECHNOLOGY PROGRESS

Host cell protein clearance during protein a chromatography: Development of an improved column wash step

(2008) Abhinav A. Shukla et al.   BIOTECHNOLOGY PROGRESS

Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming

(2008) Anne Roobol et al.   FEBS Journal