Review
Materials Science, Multidisciplinary
Mohammed E. Sayed, Maryam H. Mugri, Mazen A. Almasri, Manea Musa Al-Ahmari, Shilpa Bhandi, Thodur Balaji Madapusi, Saranya Varadarajan, A. Thirumal Raj, Rodolfo Reda, Luca Testarelli, Shankargouda Patil
Summary: This study aimed to evaluate the effect of stem cells on the osseointegration of dental implants, finding that the combination of stem cells with graft material and scaffolds promoted new bone formation and increased osseointegration levels.
Article
Materials Science, Ceramics
Nuzul Ficky Nuswantoro, Menkher Manjas, Netti Suharti, Dian Juliadmi, Hidayatul Fajri, Djong Hon Tjong, Jon Affi, Mitsuo Niinomi, Gunawarman
Summary: The study discusses the hydroxyapatite coating on a titanium alloy to enhance biocompatibility and bioactivity, demonstrating its impact on osseointegration and inflammatory reactions in bone tissue through experiments.
CERAMICS INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Parisa Khayambashi, Janaki Iyer, Sangeeth Pillai, Akshaya Upadhyay, Yuli Zhang, Simon D. Tran
Summary: Tissue engineering has a long history in regenerative medicine, and methods such as cell-encapsulated hydrogels and exosomes can enhance the regenerative potential of various tissues, with hydrogels being the most user-friendly, economical, and accessible material for encapsulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Xitong Cheng, Xiao Yang, Chengde Liu, Yizheng Li, Yangyang Zhang, Jinyan Wang, Xingdong Zhang, Xigao Jian
Summary: Apatite coatings play a critical role in enhancing the surface bioactivity and osteogenic activity of implant materials. This study proposes a strategy to improve the bonding ability between apatite coatings and substrates by constructing a three-dimensional nanoporous structure and introducing a polydopamine coating. The enhanced apatite coating exhibits better bioactivity and osteogenic differentiation, as confirmed by in vitro and in vivo experiments. This research shows great potential for the clinical application of orthopedic implants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Chiung-Chyi Shen, Shan-hui Hsu, Kai-Bo Chang, Chun-An Yeh, Hsiang-Chun Chang, Cheng-Ming Tang, Yi-Chin Yang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: This study demonstrates the superior biological properties and biocompatibility of PEG-HA-AuNP nanocomposites for cell behavior in both MC3T3-E1 cells and MSCs, as well as their potential in promoting anti-inflammatory response and endothelialization when implanted into rats subcutaneously for a period of 1 month.
Article
Chemistry, Multidisciplinary
Hiroki Miyajima, Hiroki Touji, Kazutoshi Iijima
Summary: Bone-like hydroxyapatite (HAp) was prepared from 1.5SBF with different pH values, resulting in micro-sized particles with higher Ca/P ratio and crystallinity at pH 7.4, and nano-sized particles at pH 8.0 and 8.4. A mixture of micro-sized and nano-sized particles was obtained at pH 7.7. Monitoring Ca2+ concentrations showed a drastic decrease at pH 7.4, slightly decreased at higher pH, and higher at pH 7.7. The cytotoxicity of the obtained precipitates to mesenchymal stem cells was lower than that of synthetic HAp.
Article
Engineering, Biomedical
Ebrahim Rahmani-Moghadam, Tahereh Talaei-Khozani, Vahideh Zarrin, Zahra Vojdani
Summary: The study found that the combination of TQ and hydroxyapatite has a synergistic effect on the differentiation of mesenchymal stem cells. Alginate can slow down scaffold degradation rate and enhance mechanical strength.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Review
Nanoscience & Nanotechnology
Shengyu Jing, Hongjie Li, Hongbo Xu
Summary: In the latest research, mesenchymal stem cells derived exosomes (MSC-Exos) are identified as a potential alternative for treating refractory diabetic wounds. They have similar biological activity but less immunogenicity compared to MSCs. This review focuses on summarizing the effects of different MSC-Exos on diabetic wounds based on their origins and contents, discussing experimental conditions, target cells/pathways, and mechanisms. Additionally, the combination of MSC-Exos and biomaterials is explored to improve therapy efficacy and utilization. The clinical value and application prospects of exosome therapy, as well as the development trends of using exosomes as carriers for targeted delivery, are highlighted.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Engineering, Biomedical
Tong Liu, Jia Xu, Xun Pan, Zhangfan Ding, Hao Xie, Xiaoyi Wang, Huixu Xie
Summary: Autologous tissue transplantation is an effective method for restoring oral and maxillofacial functions and aesthetics, but faces limitations such as complications from donor sites, limited tissue volume, and uncertain long-term outcomes. Adipose-derived mesenchymal stem cells (ADMSCs) have multilineage differentiation capabilities and are important for oral and maxillofacial tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Analytical
Yun-Liang Chang, Chia-Ying Hsieh, Chao-Yuan Yeh, Chih-Hao Chang, Feng-Huei Lin
Summary: This study investigated the use of Gel/HA-HAP and Gel/HA-HAP-SDF-1 composites in enhancing bone regeneration in a bone defect model. The results showed that both Gel/HA-HAP composite groups exhibited better bone generation compared to the control group, with the composite containing SDF-1 showing a trend of faster bone growth. This suggests that Gel/HA-HAP-SDF-1 composites may be a feasible material for filling traumatic bone defects.
Article
Cell Biology
Jeevithan Elango, Rodion Bushin, Artiom Lijnev, Piedad N. De Aza, Carlos Perez-Albacete Martinez, Jose Manuel Granero Marin, Ana Belen Hernandez, Luis Ramon Meseguer Olmo, Jose Eduardo Mate Sanchez De Val
Summary: Hydroxyapatite (HA) is a mineral component used for repair and regeneration of mineralized tissues. The addition of germanium (Ge) improves the properties of HA and shows biocompatibility with BM-MSCs.
Article
Polymer Science
Ahmad Jabir Rahyussalim, Dina Aprilya, Raden Handidwiono, Yudan Whulanza, Ghiska Ramahdita, Tri Kurniawati
Summary: This study evaluated the in vivo biocompatibility and tissue-scaffold integration of a polylactic acid (PLA) scaffold combined with alginate/hydroxyapatite (HA) and mesenchymal stem cell (MSc) injections. The results showed that the synthetic scaffold had similar tissue reaction and tissue integration profile as the autograft.
Article
Engineering, Biomedical
Tingben Huang, Chenxi Tu, Tong Zhou, Zhou Yu, Yuchen Wang, Qiong Yu, Ke Yu, Zhiwei Jiang, Changyou Gao, Guoli Yang
Summary: In this study, poly(ethylene glycol)methyl ether methacrylate (poly(PEGMA)) was grafted onto a titanium surface to reduce osteogenic integration by preventing cell adhesion. Cell apoptosis analysis showed that the new surface did not induce apoptosis of bone marrow mesenchymal stem cells (BMSCs). Adhesive and proliferative behaviors of BMSCs on the surface were analyzed, indicating that the poly(PEGMA) surface could inhibit BMSCs proliferation by resisting adhesion. In vivo experiments demonstrated that the presence of poly(PEGMA) resulted in lower bone formation and osseointegration compared to the titanium group.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Filip Humenik, Jan Danko, Lenka Kresakova, Katarina Vdoviakova, Vladimir Vrabec, Emilia Vasilova, Maria Giretova, Stefan Toth, Zuzana Fagova, Jan Babik, Lubomir Medvecky
Summary: The aim of this study is to investigate the beneficial treatment effect of a novel chitosan bio-polymeric material enriched with mesenchymal stem cell products derived from the canine adipose tissue (AT-MSC) on artificial skin defects. Histological analysis and scoring system were used to evaluate the regeneration process, showing accelerated and improved healing in the treatment group compared to the negative control. Additionally, the chitosan-based biomaterial also promoted hair follicle and epidermis layer formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Sivasankar Murugan, Sreenivasa Rao Parcha
Summary: This article provides a brief overview of fabrication techniques for PCL/HA composite scaffolds, including sol-gel, rapid prototyping, electro-spinning, etc., which can tailor the morphological, mechanical, and biodegradability properties of the scaffolds for bone tissue regeneration. Among these methods, the 3D plotting method shows improvements in pore architecture, mechanical properties, biodegradability, and good bioactivity in bone tissue regeneration.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Polymer Science
Dong Quan, Peter Moloney, Declan Carolan, Hisham Abourayana, Calvin Ralph, Alojz Ivankovic, Denis Dowling, Neal Murphy
Summary: This study found that plasma treatment of short basalt fibers can enhance adhesion between the fibers and epoxy resin, leading to improved mechanical properties and fracture toughness of the composites. Synergistic toughening effects were observed when using plasma-activated BF/MWCNT hybrid modifiers, showing potential for developing strong, tough, and electrically conductive epoxy composites.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Composites
Gennaro Scarselli, Dong Quan, Neal Murphy, Brian Deegan, Denis Dowling, Alojz Ivankovic
Summary: This study focuses on the adhesive bonding of thermoplastic composites in aerospace applications, specifically PPS, PEEK, and PEI carbon fiber composites. Different surface treatments such as atmospheric plasma and UV radiation significantly improved the performance of PEEK and PPS joints, while PEI remained unaffected and performed well throughout.
APPLIED COMPOSITE MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Emmanuel J. Ekoi, Andrew N. Dickson, Denis P. Dowling
Summary: This paper evaluates the mechanical properties of woven continuous carbon fibre composites printed by additive manufacturing (AM) and compares them with nonwoven composites. The woven composites showed significantly higher strength and superior fatigue performance compared to the nonwoven composites, indicating their potential for high cyclic load applications.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Engineering, Manufacturing
Darragh S. Egan, Caitriona M. Ryan, Andrew C. Parnell, Denis P. Dowling
Summary: This study investigated the use of statistical anomaly detection to analyze in-situ process monitoring data during Laser Powder Bed Fusion (L-PBF), finding that the Generalized Extreme Studentized Deviate (GESD) test is effective for identifying defective layers created during the process.
JOURNAL OF MANUFACTURING PROCESSES
(2021)
Article
Nanoscience & Nanotechnology
F. R. Kaschel, R. K. Vijayaraghavan, P. J. McNally, D. P. Dowling, M. Celikin
Summary: Thermal heat treatment is commonly used to enhance the mechanical performance of additively manufactured titanium components. Stress relaxation and phase transformation were investigated through isothermal heat treatments and high temperature X-ray Diffraction. Isothermal holding at 400 degrees Celsius increased ultimate tensile strength and yield strength, while treatments between 550 and 700 degrees Celsius promoted martensitic decomposition and decreased ductility.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Nanoscience & Nanotechnology
Yaoyi Geng, Wenlong Xie, Yuhui Tu, Siying Deng, Darragh Egan, Denis P. Dowling, Hongwu Song, Shihong Zhang, Noel Harrison
Summary: In this study, a functionally graded material (FGM) made of Ti-6Al-4V was fabricated using a powder bed fusion additive manufacturing technique. The microstructure of the FGM was analyzed at selected build locations, showing a gradient in grain morphology and texture intensity. Nanoindentation revealed a smooth gradient elastic modulus profile, with peak values at the midpoint of the gauge length. Tensile tests showed a gradient of local maximum principal strain in the highly {0001} textured section, while the reference sample exhibited a near-uniform strain distribution throughout the whole gauge length. A crystal plasticity finite element (CPFE) model was developed to explain the effect of texture on the mechanical properties. Despite higher elastic modulus in the transverse direction, the mid-section of the gauge length accumulated a higher concentration of strain when loaded in the axial tensile direction, due to a high intensity of {0001} texture.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Review
Engineering, Manufacturing
Ronan McCann, Muhannad A. Obeidi, Cian Hughes, Eanna McCarthy, Darragh S. Egan, Rajani K. Vijayaraghavan, Ajey M. Joshi, Victor Acinas Garzon, Denis P. Dowling, Patrick J. McNally, Dermot Brabazon
Summary: Process monitoring and sensing play a crucial role in additive manufacturing, offering the potential for in-depth control of the powder bed fusion process for enhanced industrial credibility and adoption.
ADDITIVE MANUFACTURING
(2021)
Article
Management
Michael Walls, Heather O'Connor, Denis P. Dowling, Jamie Goggins
Summary: Tidal turbine applications require composite materials to withstand high pressures and ensure technical reliability against dynamic loads. Moisture saturation is detrimental to GFRP materials, but hydrophobic coatings may help protect them.
INFRASTRUCTURE ASSET MANAGEMENT
(2021)
Article
Engineering, Manufacturing
F. R. Kaschel, S. Keaveney, D. P. Dowling
Summary: This study investigated the difference between the properties of Ti-6Al-4 V alloy parts printed using continuous wave (CW) and modulated wave (MW) laser emission modes. The impact of changes in laser emission mode and energy density was examined based on printed part dimensions, microstructure, porosity, hardness and tensile properties.
ADDITIVE MANUFACTURING
(2022)
Article
Automation & Control Systems
Axieh Joy I. Bagasol, Frederico R. Kaschel, Saranarayanan Ramachandran, Wajira Mirihanage, David J. Browne, Denis P. Dowling
Summary: This study investigated the print homogeneity of Ti-6Al-4 V alloy parts over a large build area using a production scale laser powder bed additive manufacturing system. It found that the part porosity increased slightly with distance from the gas flow inlet, but no significant differences were obtained for microstructural features and mechanical properties across the build area. The study also observed partial in-situ decomposition of a' -> a + Q phases during printing and a decrease in strength after HIP treatment.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Lu Yang, Saranarayanan Ramachandran, Axieh Bagasol, Qiyu Guan, Weiguang Wang, David J. Browne, Denis Dowling, Wajira Mirihanage
Summary: Laser powder bed fusion (LPBF) technology enables the production of metallic components without conventional design and manufacturing constraints. By reconstructing the as-solidified microstructure across the LPBF build volume, the initial solidification microstructure of Ti-6Al-4V alloy can be revealed, providing insights into the early stages of solidification. This approach also has the potential to explore solidification microstructure and defect formation in titanium alloys during additive manufacturing.
SCRIPTA MATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Zoheb Khan, Xiaoyan Long, Eoin Casey, Denis Dowling, Steven Ferguson
Summary: The objective of this study is to develop a fully continuous operation for separations based on diafiltration using semipermeable nanofiltration or ultrafiltration membranes. A continuous spatially distributed diafiltration (CSDD) operation is developed to achieve continuous single stage diafiltration with equivalent or better purification efficiency than batch and incumbent continuous diafiltration configurations. By introducing a diafiltration solvent spatially across the membrane unit in a highly uniform manner using 3D-printed static mixers, CSDD improves solvent consumption and yield compared to batch diafiltration. CSDD may serve as an attractive intermediate purification and solvent swap operation for telescoped flow chemical and continuous processing applications.
REACTION CHEMISTRY & ENGINEERING
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
Bryan Naab, Denis P. Dowling, Mert Celikin
Summary: The evolution of microstructure in Ti-6Al-4V alloy produced via selective laser melting (SLM) was studied after furnace heat treatments to 850 degrees C. The heat-treated microstructure showed the formation of α-martensite laths with a thickness of around 1.8 μm and the presence of β-phase based on XRD analysis.
TMS 2022 151ST ANNUAL MEETING & EXHIBITION SUPPLEMENTAL PROCEEDINGS
(2022)
Article
Chemistry, Physical
Matteo Bonomo, Emmanuel J. Ekoi, Andrea G. Marrani, Ana Y. Segura Zarate, Denis P. Dowling, Claudia Barolo, Danilo Dini
Summary: The nanocomposites of nickel oxide (NiO) and zirconia (ZrO2) are effective photocathodic materials in dye-sensitized solar cells. The reduction in electrolyte resistance in t-DSCs leads to an increase in photocurrent, demonstrating the potential for efficient tandem devices.
SUSTAINABLE ENERGY & FUELS
(2021)
Article
Chemistry, Multidisciplinary
Matthew J. Harding, Bin Feng, Rafael Lopez-Rodriguez, Heather O'Connor, Denis Dowling, Geoff Gibson, Kevin P. Girard, Steven Ferguson
Summary: The low-cost continuous liquid-liquid phase separator developed is modular, robust, and easily customisable, making it suitable for various solvent systems and process parameters. Scale-up is simple with the ability to increase units or scale operations, while an additively manufactured back pressure regulator allows for accurate and adjustable pressure control.
REACTION CHEMISTRY & ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Zhi-Min Zhao, Zhi-Hua Liu, Tongtong Zhang, Rongqian Meng, Zhiqun Gong, Yibing Li, Jing Hu, Arthur J. Ragauskas, Bing-Zhi Li, Ying-Jin Yuan
Summary: Bioconversion of bioresources/wastes using Rhodococcus is a promising approach for producing lipid-derived bioproducts. However, bioconversion involves living cells and is a complex system that requires further understanding. This review highlights the potential of Rhodococcus for producing lipids from various wastes and presents genetic modifications using emerging tools for promoting bioconversion. Additionally, strategies for enhancing the bioaccessibility of lignin and its derived aromatics and synthesizing biodiesel and aviation fuels from lignin and lipids are discussed. The synergistic modification of microbial strains, substrates, and fermentation processes is proposed for sustainable biological lignin valorization.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Maddy L. Newby, Joel D. Allen, Max Crispin
Summary: A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins. Glycosylation can influence the antigenicity and immunogenicity of vaccines, with native-like glycosylation potentially enhancing immunogenicity. Understanding viral glycosylation can guide the development of future vaccines in various enveloped viruses.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Uganeeswary Suparmaniam, Man Kee Lam, Jun Wei Lim, Inn Shi Tan, Bridgid Lai Fui Chin, Siew Hoong Shuit, Steven Lim, Yean Ling Pang, Peck Loo Kiew
Summary: Microalgae have the ability to synthesize high-value phytochemicals, and subjecting them to abiotic stress can enhance the accumulation of valuable metabolites within their cells. This study explores the effects of manipulating abiotic stress on microalgae yields and discusses approaches to increase HVPCs production using abiotic stress.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Pei Zhou, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu, Xiulai Chen
Summary: The engineering status of protein is crucial for the efficient bioproduction in microbial cell factories. Strategies such as protein engineering, protein modification, and protein assembly can effectively modify the protein status and enhance production efficiency.
BIOTECHNOLOGY ADVANCES
(2024)