期刊
BIOTECHNOLOGY ADVANCES
卷 29, 期 4, 页码 418-435出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2011.03.004
关键词
Cyclosporin A; Fermentation; Immunosuppressants; Tolypocladium inflatum
In present times, the immunosuppressants have gained considerable importance in the world market. Cyclosporin A (CyA) is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal and antiparasitic properties. CyA is produced by various types of fermentation techniques using Tolypocladium inflatum. In the present review, we discuss the biosynthetic pathway, fermentative production, downstream processing and pharmacological activities of CyA. (C) 2011 Elsevier Inc. All rights reserved.
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