Review
Medical Laboratory Technology
Ting Chen, Tiannan Liu, Ting Li, Hang Zhao, Qianming Chen
Summary: The review introduces the conventional and emerging methods for breath analysis in diagnosing and monitoring various diseases. It discusses the correlation between breath components and specific diseases, as well as unique ideas and devices for the diagnosis of common diseases through exhaled breath analysis. The potential application of exhaled breath analysis for diagnosing and screening different diseases is briefly introduced, offering a new avenue for non-invasive disease detection.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Wadah Ibrahim, Michael J. Wilde, Rebecca L. Cordell, Matthew Richardson, Dahlia Salman, Robert C. Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol A. Gaillard, Toru Suzuki, Leong L. Ng, Tim Coats, Paul Thomas, Paul S. Monks, Christopher E. Brightling, Neil J. Greening, Salman Siddiqui, EMBER Consortium
Summary: Acute cardiorespiratory breathlessness is a significant cause of emergency hospitalizations. This study identified breath volatile organic compound biomarkers that can diagnose acute cardiorespiratory disease and investigated the metabolic enrichment patterns in acute disease. The findings demonstrate that the multibiomarker score can effectively differentiate acute disease from health and different subtypes of acute cardiorespiratory exacerbation. Furthermore, the study revealed specific enrichment patterns in different subgroups of acute disease.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Analytical
Yolande Christelle Ketchanji Mougang, Laurent-Mireille Endale Mangamba, Rosamaria Capuano, Fausto Ciccacci, Alexandro Catini, Roberto Paolesse, Hugo Bertrand Mbatchou Ngahane, Leonardo Palombi, Corrado Di Natale
Summary: Tuberculosis is a common cause of death in many countries, and the current diagnostic method of smear microscopy has a low true positive rate. Analyzing exhaled VOCs using sensors has been proposed as a promising alternative for disease diagnosis. Testing an electronic nose based on sensor technology in a Cameroon hospital showed promising results for the diagnosis of pulmonary TB.
Article
Chemistry, Physical
Maedeh Mashhadbani, Edris Faizabadi
Summary: In this study, armchair stanene nanoribbons were analyzed as excellent sensing substances for early lung cancer diagnosis. Modified configurations of surface- and edge-defected nanoribbons were studied to improve sensing performance. The results showed that armchair stanene nanoribbons have at least five times greater adsorption energy than other reported substances, such as carbon nanotubes, phosphorene, and silicene. The sensitivity and selectivity of the system were found to be improved by configurations with single vacancy and edge defects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Chemistry, Analytical
Chuntae Kim, Iruthayapandi Selestin Raja, Jong-Min Lee, Jong Ho Lee, Moon Sung Kang, Seok Hyun Lee, Jin-Woo Oh, Dong-Wook Han
Summary: This review discusses the importance of artificial olfactory systems in fields such as healthcare, along with the trend and prospects of using these systems for disease diagnosis. Monitoring health status and early disease diagnosis are crucial in modern healthcare, with the potential to increase survival rates and reduce treatment costs. The article introduces promising technologies for real-time monitoring of health conditions and early disease diagnosis through analysis of exhaled human breath.
Article
Chemistry, Analytical
Blanca Nohemi Zamora-Mendoza, Hannia Sandoval-Flores, Maribel Rodriguez-Aguilar, Carlos Jimenez-Gonzalez, Luz Eugenia Alcantara-Quintana, Alejandra Abigail Berumen-Rodriguez, Rogelio Flores-Ramirez
Summary: The use of an electronic nose and chemometric analysis was evaluated to discriminate volatile organic compounds (VOCs) in breath of postCOVID syndrome patients with pulmonary sequelae. The study involved two groups: one group consisted of COVID-19 recovered individuals without lung damage, and the other group consisted of COVID-19 recovered individuals with impaired lung function. Various chemometric analysis methods were applied, including PCA, PLS-DA, random forest, and CAP, and the diagnostic power was evaluated using ROC curve. The results showed a high level of accuracy in classifying the two groups based on VOCs patterns. The study suggests that this technology can be used as an initial evaluation tool for lung damage in postCOVID patients.
Article
Biochemistry & Molecular Biology
Azamat Z. Temerdashev, Elina M. Gashimova, Vladimir A. Porkhanov, Igor S. Polyakov, Dmitry V. Perunov, Ekaterina V. Dmitrieva
Summary: This study conducted exhaled breath analysis on 112 lung cancer patients and 120 healthy individuals using gas chromatography-mass spectrometry (GC-MS). Significant correlations between volatile organic compounds (VOC) peak areas and their ratios and factors such as histological types, tumor localization, TNM stage, and treatment status were observed. The study also explored the impact of non-pulmonary comorbidities on exhaled breath composition of lung cancer patients for the first time. Artificial neural network (ANN) model achieved the highest accuracy among the developed models, with 82-88% sensitivity and 80-86% specificity on the test data.
Article
Chemistry, Multidisciplinary
Elina Gashimova, Azamat Temerdashev, Vladimir Porkhanov, Igor Polyakov, Dmitry Perunov, Ekaterina Dmitrieva
Summary: Development of simple, fast, and non-invasive tests for lung cancer diagnostics is crucial in clinical practice. This paper explores the use of exhaled breath and skin as potential objects for diagnosing lung cancer, and develops diagnostic models using machine learning algorithms. The results show that artificial neural networks perform well in classifying lung cancer patients and healthy individuals. Additionally, the study identifies significant differences in parameters in exhaled breath samples of lung cancer patients and evaluates the potential of skin analysis for lung cancer diagnosis.
Article
Medicine, General & Internal
Lisa Goudman, Julie Jansen, Nieke Vets, Ann De Smedt, Maarten Moens
Summary: This study evaluated whether an electronic nose could differentiate between chronic pain patients with Spinal Cord Stimulation (SCS) activated versus deactivated, finding that exhaled breath could not effectively distinguish between the two states in patients with Failed Back Surgery Syndrome (FBSS). The findings suggest that exhaled breath cannot be used as an additional marker of the effect of neuromodulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Analytical
Qiwen Yu, Jing Chen, Wei Fu, Kanhar Ghulam Muhammad, Yi Li, Wenxin Liu, Linxin Xu, Hao Dong, Di Wang, Jun Liu, Yanli Lu, Xing Chen
Summary: Lung cancer, with its high morbidity and mortality, has been studied for decades. Traditional methods for diagnosis are invasive and expensive, hindering early screening and diagnosis. Smartphones integrated with powerful applications show great potential for improving the detection and monitoring of lung cancer markers in various medical settings.
Article
Medicine, General & Internal
Valentina Sas, Paraschiva Chereches-Panta, Diana Borcau, Cristina-Nicoleta Schnell, Edita-Gabriela Ichim, Daniela Iacob, Alina-Petronela Coblisan, Tudor Drugan, Sorin-Claudiu Man
Summary: Electronic nose (e-nose) is a new technology used to identify volatile organic compounds (VOC) in breath air. It can adequately identify airway inflammation in asthma patients. In this study, the e-nose was able to discriminate pediatric patients with asthma from controls, but the accuracy was lower in the external validation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elina M. Gashimova, Azamat Z. Temerdashev, Dmitry V. Perunov, Vladimir A. Porkhanov, Igor S. Polyakov, Ekaterina V. Dmitrieva
Summary: Lung cancer is a major cause of death worldwide, and early diagnosis is difficult. In this study, the variability of exhaled breath samples among patients with lung cancer and other types of cancer was investigated. Two classification models were created to separate lung cancer patients from patients with cancer in other locations and to classify different types of cancer. The models showed moderate sensitivity and specificity in distinguishing lung cancer from other types of cancer, but poor accuracy in classifying different types of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Electrical & Electronic
Akhilesh Kumar Pathak, Charusluk Viphavakit
Summary: This study discusses a sensor for detecting isopropanol in exhaled breath, which is a biomarker for diabetes. The design of the sensor is based on wavelength modulation technique, utilizing a porous TiO2 layer as sensing material for high sensitivity detection.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Elina Gashimova, Anna Osipova, Azamat Temerdashev, Vladimir Porkhanov, Igor Polyakov, Dmitry Perunov, Ekaterina Dmitrieva
Summary: Gas chromatography-mass spectrometry and electronic nose were used to analyze the exhaled breath of 40 lung cancer patients and 40 healthy individuals. While GC-MS could identify significant differences between groups, the electronic nose was unable to distinguish the samples. Diagnostic models showed varying sensitivity and specificity in training and test data.
ANALYTICAL METHODS
(2021)
Article
Public, Environmental & Occupational Health
Dale S. Mantey, Stephanie I. Clendennen, Aslesha Sumbe, Anna Wilkinson, Melissa B. Harrell
Summary: This study examines the impact of stress on e-cigarette use among young people and finds that perceived stress is associated with progression and continuation of e-cigarette use among young adults, but not with initiation.
PREVENTIVE MEDICINE
(2022)
Article
Environmental Sciences
Manuel Lozano, Mario Murcia, Raquel Soler-Blasco, Maribel Casas, Begotxu Zubero, Gabriel Riutort-Mayol, Fernando Gil, Pablo Olmedo, Joan O. Grimalt, Ruben Amoros, Aitana Lertxundi, Martine Vrijheid, Ferran Ballester, Sabrina Llop
Summary: The study in pregnant Spanish women found that arsenic, cobalt, molybdenum, antimony, selenium and zinc were the most detected metals, with zinc showing the highest concentrations and thallium showing the lowest concentrations. Significant associations were observed between metal concentrations and factors such as working situation, social class and age. Dietary intake of seafood, meat, fruits, nuts, vegetables and alcohol affected all metal levels. Proximity to industrial areas, fields and air pollution were related to metal exposure.
Article
Environmental Sciences
Kam Sripada, Aneta Wierzbicka, Khaled Abass, Joan O. Grimalt, Andreas Erbe, Halina B. Rollin, Pal Weihe, Gabriela Jimenez Diaz, Randolph Reyes Singh, Torkild Visnes, Arja Rautio, Jon Oyvind Odland, Martin Wagner
Summary: This commentary summarizes the knowns and unknowns about exposures to nano-and microplastics (NMPs) during pregnancy and childhood. Currently, there is a lack of research on child-specific exposures to NMPs, and exposure estimates rely on assumptions rather than empirical measurements. Furthermore, the toxicological research on NMPs has not focused specifically on child health, despite their vulnerability. More research is needed to fill these knowledge gaps and spur policymakers and industries to address the safety of NMPs.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Raimon M. Prats, Barend L. van Drooge, Pilar Fernandez, Joan O. Grimalt
Summary: The air concentrations of organophosphate esters (OPEs) were studied in six remote high-mountain areas of the Pyrenees, and it was found that the concentrations were low and the predominant compounds varied with altitude.
Article
Environmental Sciences
Joan O. Grimalt, Merce Gari, Loreto Santa-Marina, Jesus Ibarluzea, Jordi Sunyer
Summary: Insufficient gestational weight gain not only leads to fetal exposure, but also increases the transfer of pollutants to infants during breastfeeding.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Miguel Garcia-Villarino, Antonio J. Signes-Pastor, Margaret R. Karagas, Isolina Riano-Galan, Cristina Rodriguez-Dehli, Joan O. Grimalt, Eva Junque, Ana Fernandez-Somoano, Adonina Tardon
Summary: This study found that exposure to metal mixtures impacts growth indicators in children, with negative associations between cadmium and arm circumference, head circumference, and standing height, as well as lead and cobalt with reduced standing height and head circumference, and a positive association between molybdenum and head circumference.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Shanshan Xu, Solrunn Hansen, Arja Rautio, Marjo-Riitta Jarvelin, Khaled Abass, Jaana Rysa, Saranya Palaniswamy, Sandra Huber, Joan O. Grimalt, Pierre Dumas, Jon Oyvind Odland
Summary: This study found lower levels of selected persistent organic pollutants (POPs) in the serum of women from Northern Norway, with concentrations of dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and chlorinated paraffins showing decreasing trends over the studied period. However, medium chain chlorinated paraffins exhibited an increasing trend, raising concerns about their emerging contamination impact on humans. Further global observational studies with larger sample sizes on chlorinated paraffins are needed to validate these findings.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Joan O. Grimalt, Helem Vilchez, Pablo A. Fraile-Ribot, Esther Marco, Antoni Campins, Jaime Orfila, Barend L. van Drooge, Francisco Fanjul
Summary: The study found higher levels of SARS-CoV-2 RNA in the rooms with COVID-19 patients and adjacent corridors, which was related to ventilation systems.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Khaled Abass, Tatiana Unguryanu, Eva Junque, Darja Mazej, Janja Snoj Tratnik, Milena Horvat, Joan O. Grimalt, Paivi Myllynen, Arja Rautio
Summary: In the Finnish Lapland, possible pollution transferred from the Pechenganikel industrial complex was investigated. Food samples and blood samples of pregnant women from the local area were analyzed, and detectable levels of organochlorine compounds and metal(oids) were found. However, the levels of these pollutants did not exceed safe limits, and there was a decrease in pollutant concentrations compared to previous studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Natalia Bravo, Merce Gari, Joan O. Grimalt
Summary: This study investigated the presence of eight pesticide metabolites in urine samples from farmworkers and residents in a rural township in Catalonia, Spain. The results showed higher concentrations of pesticide metabolites among farmworkers, indicating occupational exposure. However, there was also a general exposure to these compounds among the rural population.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Miguel Garcia-Villarino, Antonio J. Signes-Pastor, Isolina Riano-Galan, Ana Cristina Rodriguez-Dehli, Esther Vizcaino, Joan O. Grimalt, Ana Fernandez-Somano, Adonina Tardon
Summary: This study investigated the association between prenatal exposure to POP mixtures and anogenital distance. The results showed a negative correlation between maternal exposure to POPs and AGD in male children, and a positive correlation in female children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Eva Junque, Adonina Tardon, Ana Fernandez-Somoano, Joan O. Grimalt
Summary: Urine samples from four-year-old children in a heavily industrialized zone in Asturias, Spain were analyzed to determine their metal concentration. The study found that children in this area had higher levels of vanadium, arsenic, antimony, cesium, and thallium compared to children from other sites. The diet, especially terrestrial food items like red meat and pasta, was strongly associated with increased metal concentrations in children's urine.
ENVIRONMENTAL RESEARCH
(2022)
Editorial Material
Engineering, Environmental
Marlene Agerstrand, Kenneth Arinaitwe, Thomas Backhaus, Ricardo O. Barra, Miriam L. Diamond, Joan O. Grimalt, Ksenia Groh, Faith Kandie, Perihan Binnur Kurt-Karakus, Robert J. Letcher, Rainer Lohmann, Rodrigo O. Meire, Temilola Oluseyi, Andreas Schaeffer, Mochamad Septiono, Gabriel Sigmund, Anna Soehl, Temitope O. Sogbanmu, Noriyuki Suzuki, Marta Venier, Penny Vlahos, Martin Scheringer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Laine, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa -Marina, Martine Vrijheid, Cecile Chevrier, Maribel Casas, Charline Warembourg
Summary: Several studies have shown that prenatal exposure to certain persistent organic pollutants (POPs) is associated with higher adiposity in childhood. This study aimed to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. The findings suggest that prenatal exposure to POPs, especially organochlorine pesticides, is linked to unfavorable cardiometabolic health up to the age of 12.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Vasiliki Margari, David A. Hodell, Simon A. Parfitt, Nick M. Ashton, Joan O. Grimalt, Hyuna Kim, Kyung-Sook Yun, Philip L. Gibbard, Chris B. Stringer, Axel Timmermann, Polychronis C. Tzedakis
Summary: Through analyzing deep-sea sediment samples from the Portuguese margin, researchers found pronounced millennial-scale climate variability during the glacial period around 1.154 to 1.123 million years ago, including a terminal stadial cooling comparable to the most extreme events of the last 400,000 years. Climate simulations indicate a drastic decrease in suitability of early human habitats around the Mediterranean during the terminal stadial. These extreme conditions led to the depopulation of Europe, potentially lasting for several successive glacial-interglacial cycles.
Article
Engineering, Environmental
Andreas Schaeffer, Ksenia J. Groh, Gabriel Sigmund, David Azoulay, Thomas Backhaus, Michael G. Bertram, Bethanie Carney Almroth, Ian T. Cousins, Alex T. Ford, Joan O. Grimalt, Yago Guida, Maria C. Hansson, Yunsun Jeong, Rainer Lohmann, David Michaels, Leonie Mueller, Jane Muncke, Gunilla Oberg, Marcos A. Orellana, Edmond Sanganyado, Ralf Bernhard Schaefer, Ishmail Sheriff, Ryan C. Sullivan, Noriyuki Suzuki, Laura N. Vandenberg, Marta Venier, Penny Vlahos, Martin Wagner, Fang Wang, Mengjiao Wang, Anna Soehl, Marlene Agerstrand, Miriam L. Diamond, Martin Scheringer
Summary: Pollution caused by chemicals and waste, along with climate change and biodiversity loss, poses a triple planetary crisis. In response, countries have established an intergovernmental science-policy panel to address chemicals, waste, and pollution prevention. Protecting this panel from conflicts of interest is crucial for its success.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)