Article
Chemistry, Multidisciplinary
Ban Chen, Xiaojian Ouyang, Chunfeng Cheng, Dongfeng Chen, Jiangtao Su, Yuchen Hu, Xican Li
Summary: This study successfully screened antioxidant and anti-ferroptotic RAS peptides through optimized extraction and hydrolysis protocols. These peptides can scavenge radicals and protect cells from ferroptosis by directly inhibiting protein-protein interactions.
Article
Food Science & Technology
Ana Ruiz de la Bastida, Angela Peiroten, Susana Langa, Jose Antonio Curiel, Juan Luis Arques, Jose Maria Landete
Summary: Fermenting soy beverages with bacterial strains Limosilactobacillus mucosae INIA P508 and Bifidobacterium pseudocatenulatum INIA P815 can increase the concentration of isoflavone aglycones and other bioactive flavonoids. Cold storage and thermal treatment do not impact the levels of isoflavones, allowing these functional beverages to maintain their nutrients under different storage conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohsen Akbarian, Ali Khani, Sara Eghbalpour, Vladimir N. Uversky
Summary: This article reviews the various production methods and sources of bioactive peptides, explores their applications in antimicrobial, antioxidant, and blood-lipid-lowering effects, and discusses the future prospects of bioactive peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Andrea Cerrato, Sara Elsa Aita, Chiara Cavaliere, Aldo Lagana, Carmela Maria Montone, Susy Piovesana, Riccardo Zenezini Chiozzi, Anna Laura Capriotti
Summary: The study analyzed native peptides from sea bass muscle using two different approaches: peptidomics analysis for medium-sized peptides and suspect screening analysis for short peptides. The method can also be extended to any peptide mixture from other food matrices.
Review
Nutrition & Dietetics
Ana G. Abril, Manuel Pazos, Tomas G. Villa, Pilar Calo-Mata, Jorge Barros-Velazquez, Monica Carrera
Summary: Bioactive peptides have various health benefits and can be identified and quantified through proteomics. They have the potential to be a source of novel drugs and ingredients in food and pharmaceuticals.
Article
Chemistry, Physical
Thiago C. Lourenco, Lucas R. de Mello, Marcelo Y. Icimoto, Renata N. Bicev, Ian W. Hamley, Valeria Castelletto, Clovis R. Nakaie, Emerson R. da Silva
Summary: This study presents a strategy for fabricating highly ordered 1D nanostructures of Bradykinin (BK) using DNA fragments as a template for self-assembly. The nanoscale structure of BK-DNA complexes was revealed, showing the formation of ordered nanofibrils. The complexes retained the native bioactivity of BK and could induce a limited uptake of nucleotides by HEK-293t cells, which has not been previously reported.
Review
Biochemistry & Molecular Biology
Lei Luo, Peter Muiruri Kamau, Ren Lai
Summary: The venom of wasps contains various bioactive components, including peptides and proteins, which possess antimicrobial, anti-inflammatory, antitumor, and anticoagulant activities. These bioactive peptides and proteins may be potential sources of pharmaceutically active molecules. However, the venom can also cause allergic reactions and tissue damage.
Article
Biochemistry & Molecular Biology
Shiva Abbasi, Maryam Moslehishad, Maryam Salami
Summary: This study evaluated the antioxidant activity and alpha-glucosidase inhibition effect of bioactive peptides obtained from quinoa protein hydrolyzed by alcalase and trypsin. It was found that the molecular weight and composition of the peptides influenced these traits. The bioactive peptides obtained from quinoa protein could be used in the formulation of functional food and supplements.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Infectious Diseases
Norma Rivera-Fernandez, Jhony Anacleto-Santos, Brenda Casarrubias-Tabarez, Teresa De Jesus Lopez-Perez, Marcela Rojas-Lemus, Nelly Lopez-Valdez, Teresa Fortoul
Summary: Apicomplexan parasites, including Toxoplasma gondii, Cryptosporidium, and Plasmodium falciparum, cause medically important diseases such as toxoplasmosis, cryptosporidiosis, and malaria. Current drugs for these diseases have limitations, and peptide-based drugs have emerged as potential alternatives due to their ability to kill infectious agents and modulate the immune response. However, the development of effective peptide drugs still faces challenges.
Review
Biochemistry & Molecular Biology
Priya Antony, Ranjit Vijayan
Summary: Research has shown that food-derived bioactive peptides have anti-diabetic activity by reducing blood glucose levels, improving insulin uptake, and inhibiting key enzymes in diabetes development. Dietary proteins contain a rich source of anti-diabetic peptides, offering multiple benefits in developing nutraceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Veymar G. Tacias-Pascacio, Daniel Castaneda-Valbuena, Roberto Morellon-Sterling, Olga Tavano, Angel Berenguer-Murcia, Gilber Vela-Gutierrez, Irfan A. Rather, Roberto Fernandez-Lafuente
Summary: The article focuses on the application of papain in the hydrolysis of proteins from fish residues, converting the residual material into interesting products with antioxidant, nutritional, and functional activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Nutrition & Dietetics
Innocent U. Okagu, Joseph C. Ndefo, Emmanuel C. Aham, Joy Obeme-Nmom, Precious E. Agboinghale, Rita N. Aguchem, Regina N. Nechi, Carmen Lammi
Summary: The paper discusses the intestinal transport, bioavailability and biological activities of Lupin-derived peptides (LDPs), highlighting their potential multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, as well as antioxidant and anti-inflammatory activities, positioning them as promising candidates for nutraceutical development for multifactorial medical conditions.
Review
Food Science & Technology
Hija Athman Katimba, Rongchun Wang, Cuilin Cheng
Summary: More than two billion people worldwide are affected by zinc deficiency, and bioactive peptides show potential in combating this issue by chelating zinc. Research has shown that these peptides can enhance the absorption and transportation of zinc, with higher bioavailability compared to zinc salts. The structure-function relationship and transport mechanism of zinc chelating peptides are also discussed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biotechnology & Applied Microbiology
Sabrina Swan Souza da Silva, Alexsandra Frazao de Andrade, Milena de Paiva-Cavalcanti, Joao Carlos Monteiro de Carvalho, Daniela de Araujo Viana-Marques, Carolina de Albuquerque Lima Duarte, Ana Lucia Figueiredo Porto, Raquel Pedrosa Bezerra
Summary: Leishmaniasis is a global public health issue with limited treatment options. Microalgae and cyanobacteria show potential as candidates for new drug development, particularly peptides.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Dingyi Yu, Shenghao Cui, Liqi Chen, Shuang Zheng, Di Zhao, Xinyu Yin, Faming Yang, Jingdi Chen
Summary: In recent years, peptide self-assembling materials have gained attention in various fields of study. This research focused on obtaining supramolecular peptide self-assembling materials (CAPs) from Pacific oysters via enzymatic hydrolysis. The study explored the pro-healing mechanisms of CAPs on skin wounds through in vitro and in vivo experiments, revealing their potential for traceless wound healing.