期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1426, 期 -, 页码 220-225出版社
ELSEVIER
DOI: 10.1016/j.chroma.2015.11.024
关键词
Nanoparticles; Diffusion coefficient; Hydrodynamic radius; Taylor dispersion analysis; Capillary electrophoresis; Multiple UV detection points
资金
- Region Languedoc-Roussillon
- Institut Universitaire de France
Separation of closely related nanoparticles is still a challenging issue for the characterization of complex mixtures for industrial/research applications or regulatory purposes. In this work, the remarkable separating performances of CE were complemented with the absolute size-based determination provided by Taylor dispersion analysis (TDA) for the characterization of nanoparticle mixtures. The inline hyphenation of CE to TDA was successfully implemented for the baseline separation followed by a size-based characterization of a bimodal mixture containing two closely size-related nanolatexes (70 nm and 56 nm radii). A pixel sensor UV area imager providing three detection points along the capillary was used for a differential measurement of the peak broadening during the Taylor dispersion step. Comparison of this new technique with dynamic light scattering and hydrodynamic chromatography is also discussed. (C) 2015 Elsevier B.V. All rights reserved.
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