期刊
BIOTECHNIQUES
卷 47, 期 3, 页码 747-751出版社
INFORMA HEALTHCARE
DOI: 10.2144/000113218
关键词
DNA archiving; information storage in DNA
资金
- Canadian Institutes of Health Research (CIHR) [37779]
An improved Huffman coding method for information storage in DNA is described. The method entails the utilization of modified unambiguous base assignment that enables efficient coding of characters. A plasmid-based library with efficient and reliable information retrieval and assembly with uniquely designed primers is described. We illustrate our approach by synthesis of DNA that encodes text, images and music, which could easily be retrieved by DNA sequencing using the specific primers. The method is simple and lends itself to automated information retrieval.
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