期刊
BIOSYSTEMS
卷 92, 期 1, 页码 76-81出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2007.12.004
关键词
quorum sensing; efficiency sensing; cell-cell communication; noise reduction
Autoinducer sensing, also known as quorum sensing, is the communication of bacteria by autoinducer (small signaling molecules). Cells respond on extremely low concentrations of autoinducer: only one or two molecules per cell are sufficient. At this signal level a high degree of noise is inherent. We ask for the mechanism that is able to overcome the stochasticity of the signal. By means of a model and parameter fitting we show that the sensing module acts as a low pass filter, representing the biochemical equivalent of a moving average. It is shown that the system works most sensitive in the range of 0-50 nM autoinducer. Moreover, the time scale of the reaction depends on the signal strength in a crucial manner. Nonlinear feedback is able to further enhance the sensitivity. The biological implications of the low pass filter property are discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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