期刊
BIOSENSORS & BIOELECTRONICS
卷 122, 期 -, 页码 189-204出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.09.035
关键词
Skin-patchable devices; Micro/nanodevices; Gene/drug delivery; Wearable sensors; Single cell
类别
资金
- UNT
- National Natural Science Foundation of China [51803062]
- Natural Science Foundation of Guangdong Province of China [2018A030310379]
- National Postdoctoral Program for Innovation Talents [BX201700079]
- China Postdoctoral Science Foundation [2017M620371]
- Foundation for Distinguished Young Talents in Higher Education of Guangdong Province [2017KQNCX001]
- Nebraska Center for Integrated Biomolecular Communication (NCIBC) (NIH National Institutes of General Medical Sciences) [P20 GM113126]
Patchable devices that interface with the skin across a wide range of size scales, from cellular level down to molecular level, become increasingly attractive in biomedical research. These devices hold the potential for diagnostic and therapeutic functions with exceptional spatiotemporal precision, continuity, and convenience. Further, they afford new opportunities to integrate cloud-based technology and artificial intelligence for a smarter healthcare system. This article reviews recent advances in materials design and assembly techniques for fabricating various patchable devices, with focuses on electrical, thermal, mechanical, and chemical biosensors as well as transdermal gene and drug delivery platforms. A concluding discussion provides perspectives for future developments and outlooks in clinical applications.
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