Article
Ophthalmology
Jenna N. Hart, Ming-Chen Lu, Breanna M. Tracey, Keith D. Miller, Paul R. Lephart, Shahzad I. Mian, Maria A. Woodward
Summary: This study aims to evaluate the effect of corneal and contact lens-related culture results on visual acuity in patients with microbial keratitis. The study found that positive CLR culture results are significantly associated with improvement in visual acuity over time.
CURRENT EYE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zongkang Li, Jeonghun Yun, Xiaoya Li, Moobum Kim, Jia Li, Donghoon Lee, Angyin Wu, Seok Woo Lee
Summary: Recent advancements in wearable devices have made noninvasive healthcare monitoring possible. This study introduces a power-free smart contact lens that can detect glucose levels through color changes of multiple electrochromic electrodes, eliminating the need for external wireless systems. The device demonstrates high accuracy and reproducibility, making it a potential tool for daily health monitoring without additional power supply or devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Ophthalmology
Khatija Tabbasum, D. S. Reddy, Vivek Singh, R. Subasri, Prashant Garg
Summary: The study evaluated the efficacy of a nanosilver-based sol-gel coating in preventing biofilm formation on contact lens cases. Results showed a significant reduction in biofilm formation of tested bacteria with the coating, which remained effective for up to 30 days of exposure and exhibited no cytotoxicity to human corneal epithelial cells.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Microbiology
Yu-Jen Wang, Sung-Chou Li, Wei-Chen Lin, Fu-Chin Huang
Summary: This study reveals the abundant anaerobic Gram-positive rods present in severe keratitis isolate and characterizes the association between Acanthamoeba and ocular flora in AK progression. Further analysis shows that Blautia producta is positively correlated with the disease course, while Bacteroides ovatus is abundant in early-stage keratitis isolates.
Review
Ophthalmology
Lauren Jeang, Sonal S. Tuli
Summary: This review examines the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). The use of topical antimicrobials is the mainstay of treatment for corneal ulcers, but bacterial, fungal, and acanthamoeba ulcers present different challenges due to resistance and the lack of effective topical medications. Novel therapies and diagnostic procedures offer hope for improved treatment outcomes. Contact lens-associated microbial keratitis is a significant health issue that can cause vision loss.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Microbiology
Allison Campolo, Brian Patterson, Esther Lara, Paul Shannon, Monica Crary
Summary: Acanthamoeba keratitis is a challenging infection of the cornea, and understanding the behavior of Acanthamoebae during contact lens use and disinfection can provide insights into their colonization and the efficacy of contact lens care solutions. In this study, Acanthamoeba behavior during and after disinfection with different contact lens care solutions was examined. The results showed that all contact lens care solutions significantly impacted Acanthamoeba motility, with the solution containing PHMB showing the most effectiveness. Post-disinfection, Acanthamoebae were observed to regain motility and travel considerable distances, posing a potential risk to ocular health.
Article
Ophthalmology
Rute J. Macedo-de-Araujo, Colm McAlinden, Eef van der Worp, Jose M. Gonzalez-Meijome
Summary: This study reported a case of a 38-year-old woman with microbial keratitis caused by Pseudomonas aeruginosa. By wearing a scleral lens, the patient was able to mask and improve corneal irregularity and opacity, resulting in better visual acuity and comfort.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Mathias Roth, Christoph Holtmann, Loay Daas, Vinodh Kakkassery, Oliver Kurzai, Gerd Geerling, Sebastian Baeurle, Wesal Bayoudh, Viktoria Bruecher, Nadezhda Cvetkova-Fischer, Matthias Dias Blak, Agnes Bornstein, Charlotte Fischer, Matthias Fuest, Salvatore Grisanti, Martina C. Herwig-Carl, Sandra Kroll, Janine Lenk, Claudia Lommatzsch, Colin R. MacKenzie, Mario Matthaei, Juliane Mehlan, Elisabeth M. Messmer, Violetta Mueller, Vera Pawlik, Mahdy Ranjbar, Anna Renner-Wilde, Annekatrin Rickmann, Mark Saeger, Marc Schargus, Luisa Schwarz, Berthold Seitz, Friedrich Steindor, Jan Darius Unterlauf, Arne Viestenz, Marie von Lilienfeld-Toal, Grit Walther
Summary: Fungal keratitis is a serious ophthalmic disease with a potentially devastating outcome, and the use of contact lenses is the most important risk factor for FK in Germany. Infections among contact lens users are often caused by molds, and patients are usually younger and healthier. Extensive surgery is often required for treatment.
Article
Microbiology
Edyta B. Hendiger, Marcin Padzik, Ines Sifaoui, Maria Reyes-Batlle, Atteneri Lopez-Arencibia, Diana Zyskowska, Marta Grodzik, Anna Pietruczuk-Padzik, Jacek Hendiger, Gabriela Oledzka, Lidia Chomicz, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: Acanthamoeba keratitis is a severe corneal infection that can be effectively reduced by incorporating silver nanoparticles into contact lens solutions without increasing cytotoxicity.
Article
Chemistry, Physical
Li Ma, Kaijun Li, Jiali Xia, Chaojian Chen, Yuqi Liu, Shiying Lang, Ling Yu, Gongyan Liu
Summary: The study introduces the use of silver nanoparticles modified contact lenses as a potential strategy for treating microbial keratitis. The modified lenses exhibit strong antimicrobial activity and have proven to be effective in inhibiting microbial biofilm growth. The treatment device has demonstrated excellent biocompatibility and the ability to prevent ocular infections and corneal damage.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Microbiology
Cindy McAnally, Rhonda Walters, Allison Campolo, Valerie Harris, Jamie King, Megan Thomas, Manal M. Gabriel, Paul Shannon, Monica Crary
Summary: This study compared the efficacy of nine major MPSs on the global market against four different microorganism species and four common contact lenses. The majority of MPSs demonstrated significantly higher disinfection efficacies without contact lenses, with OPTI-FREE products showing the highest disinfection efficacy when paired with any contact lens.
Article
Ophthalmology
Nicole Carnt, Darwin C. Minassian, John K. G. Dart
Summary: This study aims to identify the risk factors for Acanthamoeba keratitis (AK) in daily disposable (DD) contact lens users compared to daily wear (DW) reusable lens users and specific risks for DD users. It is important because CL use is the main cause of microbial keratitis in many major economies, with AK accounting for approximately 50% of sight loss cases. Determining these AK risks informs practitioner advice and consumer behavior.
Article
Ophthalmology
Matthew Green, Susan Zhang, Thomas Nadivulath, Andrew Apel, Fiona Stapleton
Summary: This study found that positive cultures in suspected microbial keratitis were associated with older age, poor visual acuity, contact lens-related keratitis, anterior chamber reaction, and no prior treatment with antibiotics.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Madhura P. Chandratreya, Deepthi Mudduluru, Anitha Venugopal, Anitt K. Varghese, Aditya S. Ghorpade
Summary: The purpose of this study was to determine the predisposing risk factors, clinical characteristics, microbiological profile, and treatment outcomes of microbial keratitis in children. The results showed that trauma was the major risk factor for pediatric keratitis, and most cases responded well to medical treatment.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Takashi Suzuki, Hidenori Inoue
Summary: Infectious keratitis is a severe complication associated with contact lens wear, particularly due to gram-negative bacterial infection with Pseudomonas aeruginosa. P. aeruginosa strains with the ExoU gene and expression of elastase are significantly correlated with the size of keratitis lesions. In addition to educating contact lens wearers about proper care, the development of cleaning solutions targeting the suppression of virulence factors is necessary for preventing contact lens-related keratitis in the future.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Chemistry, Physical
Paul Z. Chen, Aaron J. Clasky, Frank X. Gu
Summary: This study presents an approach to characterize supersaturation dynamics during the growth of colloidal nanocrystals. The researchers investigate the growth of colloidal gold nanocubes and identify a triphasic sequence of supersaturation dynamics. The findings reveal that the supersaturation dynamics of nanocrystal growth can be more complex than previously understood.
NANOSCALE HORIZONS
(2022)
Review
Materials Science, Biomaterials
Jeffrey Watchorn, Aaron J. Clasky, Gayatri Prakash, Ian A. E. Johnston, Paul Z. Chen, Frank X. Gu
Summary: Mucus serves as a barrier in the human body, hindering drug delivery despite its vascularization and accessibility. Nanoparticle strategies for mucosal drug delivery include mucoadhesion and mucopenetration, depending on mucus and mucosa characteristics. While progress has been made, the understanding of mucus-nanoparticle interactions remains limited for effective clinical translation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Jiangshan Wang, Mohsen Ranjbaran, Aaron Ault, Mohit S. Verma
Summary: We developed a rapid risk-assessment assay for fecal contamination using loop-mediated isothermal amplification (LAMP) targeting Bacteroidales. The assay allows for naked-eye observation of reactions with as few as approximately 8 copies of Bacteroidales per cm(2) of the surface in the field. Our on-field studies demonstrated that the Bacteroidales LAMP assay enables quick (<50 min) assessment of fecal contamination risk from animal operations, with an 85.3% concordance compared to lab-based qPCR. These assays could be a cost-effective tool for site-specific risk determination and decision-making for fresh produce growers.
Article
Materials Science, Multidisciplinary
Jeffrey Watchorn, Samantha Stuart, Darcy C. Burns, Frank X. Gu
Summary: Optimizing delivery vehicle properties is crucial for improving the delivery of pharmaceuticals. Mucoadhesion, a designed property that enhances the interaction between polymers and mucins, is an effective approach to increase drug residence times and uptake efficiency. Using nuclear magnetic resonance, this study investigated the influence of polymer design parameters on mucoadhesion and uncovered key findings on the polymer-mucin interaction at the atomic level. The results provide insights into the importance of polymer design and mucoadhesive functional groups for drug delivery.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Engineering, Environmental
Andrew B. Holmes, Aldrich Ngan, Kayleanna Giesinger, Frank Gu
Summary: In this paper, the tunability of Se reduction products during the photocatalytic reduction of selenate over TiO2 in synthetic mine-impacted brines was investigated. It was found that the solution temperature and formic acid concentration had a significant impact on the selenate removal kinetics and selectivity towards H2Se(g) or Se0(s). A two-pronged electron transfer model was proposed to explain the selectivity under varying conditions.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Mohamed S. Kamel, Amr A. El-Sayed, Rachel A. Munds, Mohit S. Verma
Summary: During the COVID-19 pandemic, dog owners have found that their dogs help reduce stress and anxiety. Dogs can get COVID-19 from their owners but are usually asymptomatic, and it is unclear if it affects their health. It is also uncertain if dogs can transmit the virus to humans. However, sniffer dogs have shown success in detecting COVID-19-positive individuals.
Article
Engineering, Environmental
Jeffrey Thomas Martin, Tia Chai, Timothy Michael Carter Leshuk, Zachary William Young, Frank Gu
Summary: Biological selenium reduction processes are commonly used for selenium removal, but they produce organoselenium compounds with higher bioaccumulation potential and toxicity. This study evaluated buoyant photocatalysts as a potential passive advanced oxidation process for organoselenium treatment. The results showed that photocatalysis with buoyant photocatalysts fully eliminated organoselenium compounds and transformed them into less hazardous oxidized Se species. Photocatalysis may be a promising treatment technology for selenium-impacted mine water management.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Samantha Stuart, Jeffrey Watchorn, Frank X. Gu
Summary: Representing the behavior of polymeric macromolecules as machine learning features for biomaterial interaction prediction is challenging due to the sensitivity of biomacromolecular interactions to polymer properties. There is no consensus on a universal representational framework, and we provide an overview of popular classes of data representations for polymeric biomaterial machine learning while discussing their merits and limitations. Increasing the accessibility of polymeric biomaterial feature engineering knowledge will contribute to accelerating clinical translation from biomaterials discovery.
NPJ COMPUTATIONAL MATERIALS
(2023)
Article
Ophthalmology
Lyndon Jones, Nathan Efron, Kalika Bandamwar, Melissa Barnett, Deborah S. Jacobs, Isabelle Jalbert, Heiko Pult, Michelle K. Rhee, Heather Sheardown, Joseph P. Shovlin, Ulli Stahl, Adriana Stanila, Jacqueline Tan, Silvia Tavazzi, Omur O. Ucakhan, Mark D. P. Willcox, Laura E. Downie
Summary: The lifestyle choices of contact lens wearers can have negative impacts on eye health, such as poor adherence to care, sleeping in lenses, inappropriate purchases, lack of regular aftercare visits, wearing lenses while feeling unwell, wearing lenses too soon after surgery, and wearing lenses during risky behaviors. However, contact lenses can also provide therapeutic benefits. The COVID-19 pandemic introduced new challenges for contact lens wearers, including mask-associated dry eye, increased discomfort from digital device use, accidental exposure to hand sanitizers, and reduced lens usage.
Article
Environmental Sciences
Cassandra Chidiac, Timothy Michael Carter Leshuk, Frank Gu
Summary: BPCs can improve the biodegradability of NA and accelerate mineralization through a passive hybrid treatment process. Solar photocatalysis (PC) with buoyant photocatalysts (BPCs) can convert NA to more hydrophilic forms or CO2. However, NA mineralization requires impractical treatment times. In this study, simulated OSPW was pre-treated with PC for different durations before a biological treatment stage. Two-day PC pre-treatments enabled mineralization and >99.9% removal of acid-extractable organics in the secondary biological treatment. The combined PC + biotreatment achieved earlier mineralization and accelerated microbial growth compared to photocatalysis alone.
Review
Biochemistry & Molecular Biology
Mohamed S. Kamel, Rachel A. Munds, Mohit S. Verma
Summary: Herpesviruses, as powerful gene therapy tools, have been extensively used and developed as vaccine vectors to combat infectious diseases and develop cancer-related antigen vaccines. Better understanding of herpesvirus biology and the interactions between viruses and host cells can improve vaccine development and enhance safety and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Samantha Stuart, Jeffrey Watchorn, Frank X. Gu
Summary: A machine learning framework has been developed to predict the interaction behavior between polymers and proteins based on interaction data. Through the construction of structure-interaction trends, the framework improves the understanding of atomic-level structure-activity relationships and enables the discovery of new polymer formulations.
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)