4.8 Article

Facile synthesis of gold nanohexagons on graphene templates in Raman spectroscopy for biosensing cancer and cancer stem cells

期刊

BIOSENSORS & BIOELECTRONICS
卷 55, 期 -, 页码 180-186

出版社

ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.11.037

关键词

Cancer cells; Cancer stem cells; Surface enhanced Raman spectroscopy; Au nanoparticles; Graphene

资金

  1. National Science Council of Taiwan
  2. National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Project (NSYSU-KMU JOINT RESEARCH PROJECT) [NSYSU-KMU2013-I005]

向作者/读者索取更多资源

Several surface enhanced Raman spectroscopy (SERS) substrates were prepared based on in situ nucleation of gold nanohexagons (Au) on graphene (G) nanosheets (Au@G), G, Au nanoparticles and Au conjugated G nanomaterials. These were applied to enhance Raman scattering and to differentiate human breast normal, cancer and cancer stem cells. These SERS substrates at concentrations of 100 mu g/1 x 10(4) cells led to 5.4 fold increase in detecting breast cancer cells (BCCs) and 4.8 fold of sensitivity for detecting breast cancer stem cells (BCSCs) and they were able to identify and differentiate between normal cells, cancer cells and cancer stem cells. These approaches are rapid, simple and reliable for healthy normal cells, cancer cells and cancer stem cell detection which have a huge potential for cancer research for medical or biomedicine applications. (C) 2013 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Energy & Fuels

Covalent organic frameworks (COFs)-derived nitrogen-doped carbon/reduced graphene oxide nanocomposite as electrodes materials for supercapacitors

Mervat Ibrahim, Hani Nasser Abdelhamid, Aya Mohamed Abuelftooh, Saad G. Mohamed, Zhen Wen, Xuhui Sun

Summary: This study presents a method for the synthesis of a triazine covalent organic framework/graphene oxide nanocomposite, which is used to synthesize N-doped carbon/reduced graphene oxide. The in-situ synthesized N-doped carbon/reduced graphene oxide shows superior electrochemical performance and is employed as electrode materials for supercapacitors.

JOURNAL OF ENERGY STORAGE (2022)

Article Chemistry, Physical

High-Performance Lithium-Ion Battery and Supercapacitors Using Covalent Organic Frameworks (COFs)/Graphitic Carbon Nitride (g-C3N4)-Derived Hierarchical N-Doped Carbon

Mervat Ibrahim, Moataz G. Fayed, Saad G. Mohamed, Zhen Wen, Xuhui Sun, Hani Nasser Abdelhamid

Summary: This study introduces a method for synthesizing covalent organic frameworks/graphitic carbon nitride nanocomposites and preparing nitrogen-doped carbon and nitrogen-doped carbon/g-C3N4 materials through carbonization reaction. These materials can be used for supercapacitors and lithium-ion batteries, exhibiting high specific capacitance and good energy. The asymmetric supercapacitor device shows high energy and power, and the nitrogen-doped carbon/g-C3N4 electrode also demonstrates high discharge capacity.

ACS APPLIED ENERGY MATERIALS (2022)

Article Chemistry, Applied

Co@ZIF-8/TiO2 heterojunction for green hydrogen generation

Mahmoud R. Saleh, Haitham M. El-Bery, Hani Nasser Abdelhamid

Summary: A wet-incipient impregnation method was used to synthesize hierarchical porous bimetallic (Co, Zn)-zeolitic imidazolate frameworks (ZIF-8)/TiO2 for efficient photocatalytic water splitting. Co@ZIF-8/TiO2 exhibited significantly higher photocatalytic efficiency than TiO2, with a hydrogen generation rate of 13 mmol·h(-1)·g(-1) and a 151-fold increase in catalytic performance. The hierarchical porous structure of Co@ZIF-8 facilitated charge transfer and provided efficient transport channels. This study demonstrates the potential of hierarchical porous metal-organic frameworks (MOFs) as support and promoter in photocatalytic applications of TiO2.

APPLIED ORGANOMETALLIC CHEMISTRY (2023)

Article Chemistry, Applied

Antifungal and Nanozyme Activities of Metal-Organic Framework-derived CuO@C

Hani Nasser Abdelhamid, Ghada Abd-Elmonsef Mahmoud

Summary: In this study, copper-based metal-organic frameworks (MOFs) were used to synthesize copper oxide (CuO) embedded into carbon (CuO@C), which displayed high antifungal activity against four economic postharvest plant pathogens. The CuO@C nanoparticles inhibited the growth of the fungal species and decreased their enzyme activity, reducing the potentiality of fruit disease. The successful formation of CuO@C nanoparticles was confirmed using various characterization techniques.

APPLIED ORGANOMETALLIC CHEMISTRY (2023)

Article Chemistry, Inorganic & Nuclear

Dye encapsulation and one-pot synthesis of microporous-mesoporous zeolitic imidazolate frameworks for CO2 sorption and adenosine triphosphate biosensing

Hani Nasser Abdelhamid

Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.

DALTON TRANSACTIONS (2023)

Article Green & Sustainable Science & Technology

Photocatalytic degradation of paracetamol using photo-Fenton-like metal-organic framework-derived CuO@C under visible LED

Amal Abdelhaleem, Hani Nasser Abdelhamid, Mona G. Ibrahim, Wei Chu

Summary: The study utilized a copper-based metal-organic framework-derived catalyst for the photodegradation of paracetamol, observing a unique enhancement effect at extreme pH 9.9 and identifying two new substances among eight intermediates.

JOURNAL OF CLEANER PRODUCTION (2022)

Article Chemistry, Inorganic & Nuclear

Fenton-like Cerium Metal-Organic Frameworks (Ce-MOFs) for Catalytic Oxidation of Olefins, Alcohol, and Dyes Degradation

Walid Sharmoukh, Hani Nasser Abdelhamid

Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.

JOURNAL OF CLUSTER SCIENCE (2023)

Article Chemistry, Applied

MOFTextile: Metal-organic frameworks nanosheets incorporated cotton textile for selective vapochromic sensing and capture of pyridine

Hani Nasser Abdelhamid

Summary: Metal-organic frameworks (MOFs) have shown great potential for industrial applications but current synthesis processes limit their use due to the powder form. A solvothermal method was used to grow copper-based MOFs onto a cotton textile, creating a material called CuBDC@Textile. CuBDC@Textile demonstrated excellent vapor sensing properties and high adsorption capacity for pyridine. This dual-functional material holds promise for further research on MOFs in textile applications.

APPLIED ORGANOMETALLIC CHEMISTRY (2023)

Article Materials Science, Ceramics

ZnO-based nanocomposites for hydrogen generation via hydrolysis of Borohydride

Numa A. A. Althubiti, T. A. Taha, A. A. Azab, Hani Nasser Abdelhamid

Summary: The use of solid-state materials such as sodium borohydride for hydrogen storage and release can meet the requirements of the "Hydrogen Economy". This study investigated ZnO-based materials as catalysts for hydrogen release through the hydrolysis of NaBH4. The synthesis method produced nanocomposites consisting of ZnO-xTiO(2) and ZnO-xCeO(2) (x = 5 wt.% or 10 wt.%). Characterization techniques confirmed the phase purity and optical properties of the materials. The materials exhibited a high hydrogen generation rate and different activation energies.

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY (2023)

Article Chemistry, Physical

Metal-organic frameworks (MOFs)-derived ZrOSO4@C for photocatalytic synthesis of benzimidazole derivatives

Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber

Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.

MOLECULAR CATALYSIS (2023)

Article Energy & Fuels

Enhancing photocatalytic water splitting: Comparative study of TiO2 decorated nanocrystals (Pt and Cu) using different synthesis methods

Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery

Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article Chemistry, Inorganic & Nuclear

3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) for adsorption of carbon dioxide (CO2) and heavy metal ions

Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew

Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.

DALTON TRANSACTIONS (2023)

Article Chemistry, Multidisciplinary

In situ modified nanocellulose/alginate hydrogel composite beads for purifying mining effluents

Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew

Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.

NANOSCALE ADVANCES (2023)

Article Engineering, Environmental

ZIF-67 and Cobalt-based@heteroatom-doped carbon nanomaterials for hydrogen production and dyes removal via adsorption and catalytic degradation

Ayat Badry Aly Abdellatif, Haitham M. El-Bery, Hani Nasser Abdelhamid, Sahar A. El-Gyar

Summary: This study reported a method of encapsulating thiourea and D-Glucose-6 -phosphate disodium salt dihydrate into zeolitic imidazolate frameworks, and tested their potential applications as catalysts in hydrogen generation and degradation of organic dyes.

JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2022)

Article Multidisciplinary Sciences

A comparative study of the toxic effect of ZIF-8 and ZIF-L on the colonization and decomposition of shaded outdoor mice carrions by arthropods

Fatma El-Zahraa A. Abd El-Aziz, Noha Esmael Ebrahem, Hani Nasser Abdelhamid

Summary: This study examined the toxic effect of two Zinc-based metal-organic frameworks (MOFs) on carrions and arthropods found in decomposing carrions. The results showed an increase in zinc content over time. This research provides important biological information that could contribute to understanding the environmental impact of MOF materials' toxic levels.

SCIENTIFIC REPORTS (2022)

Article Biophysics

An integrated centrifugal microfluidic strategy for point-of-care complete blood counting

Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari

Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Immunity testing against COVID-19 from blood by an IoT-enabled and AI-controlled multiplexed microfluidic platform

Nabil H. Bhuiyan, Joon S. Shim

Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Influence of shear stress on electroactive biofilm characteristics and performance in microbial fuel cells

Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour

Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Cheap and portable paper chip with terrific oxidase-like activity and SERS enhancement performance for SERS-colorimetric bimodal detection of intracellular glutathione

Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li

Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes

Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau

Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.

BIOSENSORS & BIOELECTRONICS (2024)

Review Biophysics

Protease detection in the biosensor era: A review

Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov

Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Controllable self-assembled DNA nanomachine enable homogeneous rapid electrochemical one-pot assay of lung cancer circulating tumor cells

Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin

Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Therapeutic drug monitoring mediated by the cooperative chemical and electromagnetic effects of Ti3C2TX modified with Ag nanocubes

Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang

Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

CRISPR-Cas12a powered hybrid nanoparticle for extracellular vesicle aggregation and in-situ microRNA detection

Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu

Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Facile synthesis of dual-ligand europium-metal organic gels for ratiometric electrochemiluminescence detecting I27L gene

Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li

Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

The use of biological fluids in microfluidic paper-based analytical devices (μPADs): Recent advances, challenges and future perspectives

Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho

Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Development of a peptide microarray-based metal-enhanced fluorescence assay for ultrasensitive detection of multiple matrix metalloproteinase activities by using a gold nanorod-polymer substrate

Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang

Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Plasmonic digital PCR for discriminative detection of SARS-CoV-2 variants

Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon

Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode

Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu

Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Gas-responsive two-dimensional metal-organic framework composites for trace visualization of volatile organic compounds

Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang

Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.

BIOSENSORS & BIOELECTRONICS (2024)