期刊
BIOSENSORS & BIOELECTRONICS
卷 53, 期 -, 页码 486-493出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.10.028
关键词
Porous silicon; Bloch surface wave; Bloch sub-surface wave; Biosensor; Size-selective
类别
资金
- Army Research Office [W911NF-09-1-0101]
- National Science Foundation [ECCS-0746296]
- Vanderbilt Institute of Nanoscale Science and Engineering [NSF ARI-R2 DMR-0963361]
- NSF Graduate Research Fellowship
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [0746296] Funding Source: National Science Foundation
A porous silicon (PSi) grating-coupled Bloch surface and sub-surface wave (BSW/BSSW) biosensor is demonstrated to size selectively detect the presence of both large and small molecules. The BSW is used to sense large immobilized analytes at the surface of the structure while the BSSW that is confined inside but near the top of the structure is used to sensitively detect small molecules. Functionality of the BSW and BSSW modes is theoretically described by dispersion relations, field confinements, and simulated refractive index shifts within the structure. The theoretical results are experimentally verified by detecting two different small chemical molecules and one large 40 base DNA oligonucleotide. The PSi-BSW/BSSW structure is benchmarked against current porous silicon technology and is shown to have a 6-fold higher sensitivity in detecting large molecules and a 33% improvement in detecting small molecules. This is the first report of a grating-coupled BSW biosensor and the first report of a BSSW propagating mode. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据