Article
Multidisciplinary Sciences
Manash Jyoti Kalita, Kalpajit Dutta, Gautam Hazarika, Ridip Dutta, Simanta Kalita, Partha Pratim Das, Manash P. Sarma, Sofia Banu, Md. Ghaznavi Idris, Anjan Jyoti Talukdar, Sangitanjan Dutta, Ajanta Sharma, Subhash Medhi
Summary: As the COVID-19 pandemic continues to impact the world, the development of a cost-effective and efficient multiplex PCR detection assay for the virus has shown promising results. The study demonstrated rapid and sensitive detection of SARS-CoV-2 using innovative PCR techniques, with results comparable to commercially available kits. The novel approach has the potential for extended commercial applicability and offers a practical solution for resource-limited settings.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Aishwarya Venkatasubramanian, Anand Thiyagaraj, Vairamuthu Subbiah, Solaipriya Solairaja, Sangaran Arumugam, Satish Ramalingam, Sivaramakrishnan Venkatabalasubramanian
Summary: This study investigated the molecular therapeutic potential of ellagic acid in treating iodoacetamide-mediated liver steatosis, demonstrating its efficacy in regulating lipid homeostasis and gene expression. Computational analysis showed promising pharmacokinetic properties of ellagic acid compared to Simvastatin, supporting its therapeutic potential against non-alcoholic fatty liver disease.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Virology
Farman Khan, Praveen Sharma, Saurabh Pandey, Deepak Sharma, V. Vijayavarman, Neeraj Kumar, Suruchi Shukla, Himanshu Dandu, Amita Jain, Ravindra K. Garg, Hardeep S. Malhotra
Summary: COVID-19 has been associated with various neurological complications, with GBS being an important post-infectious consequence. This study found SARS-CoV-2 in the CSF of an adult patient for the first time, highlighting the need to consider separate pathogenesis in cases where COVID-19 symptoms and GBS occur concurrently. The study also suggests a neuroinvasive potential of SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahtab Peyambari, Shengxi Guan, Marilyn J. Roossinck
Summary: Experimental findings show that RdRp proteins of partitiviruses have reverse transcriptase (RT) function, can be active at lower temperatures, sparking researchers to question why these viruses have RT capabilities.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Virology
Yuka Horio, Mototada Shichiri, Yuji Isegawa
Summary: A novel method was developed to evaluate mRNA transcription activity of influenza RdRp without the use of ultracentrifugation and radioisotopes. The method showed specificity and sensitivity in quantifying mRNA synthesis, even at low levels, and was able to demonstrate the inhibition of mRNA synthesis by an RdRp inhibitor. This new approach will facilitate further research on identifying compounds that inhibit viral mRNA transcription activity of RdRp.
Article
Cardiac & Cardiovascular Systems
Kashif Khan, Isabella Albanese, Bin Yu, Yousif Shalal, Hamood Al-Kindi, Hossney Alaws, Jean-Claude Tardif, Ophelie Gourgas, Marta Cerutti, Adel Schwertani
Summary: The expressions of UⅡ, URP, and UT were significantly upregulated in patients with AVS and correlated with calcification and fibrosis. Treating human aortic valve interstitial cells with UII or URP increased cell proliferation and decreased cholesterol efflux. These findings suggest that the urotensin system plays a role in the pathogenesis of AVS and warrant further investigation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Virology
Alexander Nagy, Lenka Cernikova, Martina Stara
Summary: A new highly pathogenic avian influenza H5N1 genotype was detected in geese and ducks from a backyard farm in the Czech Republic. The Czech H5N1 virus retained the A/Eurasian_Wigeon/Netherlands/1/2020-like backbone but had an altered PB2 segment obtained from co-circulating low-pathogenic avian influenza viruses.
ARCHIVES OF VIROLOGY
(2022)
Article
Biochemical Research Methods
Shahan Azeem, Baoqing Guo, Dong Sun, Mary L. Killian, John A. Baroch, Kyoung-Jin Yoon
Summary: A SYBR (R) Green-based rtRT-PCR panel was developed for direct HA subtyping of avian influenza viruses in oropharyngeal-cloacal swabs from migratory wild birds. The panel showed faster turnaround of results and detected more subtypes compared to the current surveillance testing algorithm.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Public, Environmental & Occupational Health
B. Dinc, F. Kirca, S. Aydogan, A. Toyran, T. Basyigit, I Omay, P. Gun, M. Caglayan, A. A. Surel
Summary: This retrospective study analysed SARS-CoV-2 Real-Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) test results from a pandemic hospital in Turkey, finding higher positivity among females and younger patients (0-18 years old), as well as significantly higher positivity in August and September. This could contribute to the lower COVID-19 mortality rates in Turkey.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Leonard-Lorant, Francois Severac, Pascal Bilbault, Joris Muller, Pierre Leyendecker, Catherine Roy, Mickael Ohana
Summary: The study found that 5.2% of symptomatic confirmed COVID-19 cases had initially normal chest CT results. Patients with normal initial CT had a lower rate of death and/or mechanical ventilation compared to patients with typical COVID-19 lesions on initial CT.
EUROPEAN RADIOLOGY
(2021)
Article
Virology
Ge Li, Xun Wang, Qingmei Li, Jifei Yang, Xiao Liu, Wenbao Qi, Junqing Guo, Ruiguang Deng, Gaiping Zhang
Summary: A convenient, rapid, and reliable detection method for H7N9 avian influenza virus has been developed, with high specificity for H7 and a detection time of 10 minutes.
Article
Veterinary Sciences
Taeyo Chestley, Patrycja Sroga, Michelle Nebroski, Kate Hole, Hussaini Ularamu, Oliver Lung, Charles Nfon
Summary: In this study, the Neptune bioinformatics tool was used to identify genetic signatures specific to each Southern African Territories (SAT) 1, 2 and 3 genomes but exclusionary to the other circulating FMDV serotypes. The design of TaqMan-based real-time reverse transcriptase PCR (rRT-PCR) primer/probe sets for SAT1, SAT2 and SAT3 viruses using these unique genomic regions allowed for the potential detection and differentiation of circulating FMD SAT viruses.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Kelly Buckle, Rudolfo Bueno, Andrew McFadden, Mary van Andel, Richard Spence, Carolyn Hamill, Wendi Roe, Emilie Vallee, Fernanda Castillo-Alcala, Ronel Abila, Blesilda Verin, Bolortuya Purevsuren, Ashish Sutar, Htun Htun Win, Myo Thiha, Khin Ohnmar Lwin, Syseng Khounsy, Sengxay Phonthasy, Viliddeth Souriya, Chattouphone Keokhamphet, Jonathan Arzt, Anna Ludi, Valerie Mioulet
Summary: This study investigated the presence of FMDV RNA in healthy cattle and buffalo in Laos and Myanmar, revealing that 7.3% of animals had detectable FMDV RNA on their mucosal surfaces, suggesting subclinical infection may play a role in FMD epidemiology. Additionally, a high percentage of animals tested positive for NSP antibodies, indicating previous exposure to FMDV.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Huina Wu, Mingyuan Zou, Xiaobo Fan, Feiya Su, Feng Xiao, Meiling Zhou, Yan Sun, Fengfeng Zhao, Guoqiu Wu
Summary: A catalytic hairpin assembly (CHA) combined with lateral flow immunoassay (CHA-LFIA) method was proposed for rapid and precise detection of influenza viruses and RSV, demonstrating high sensitivity and specificity.
Article
Fisheries
Yifan Wang, Liwen Xu, Weixiang Ma, Heng Sun, Zengchao Huang, Shuanghu Cai, Jichang Jian, Yucong Huang
Summary: A mass mortality event among cultured Murray cod fry occurred in Foshan city, Guangdong province, China in December 2019, with a mortality rate of up to 45% within 15 days. The affected fish showed clinical signs, and testing revealed that they were infected with betanodavirus, a pathogen previously unreported in freshwater fish in China. This study provides important insights into the natural infection of betanodavirus in freshwater fish.
JOURNAL OF FISH DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Jaerim Kim, Hyeonjung Jung, Sang-Mun Jung, Jinwoo Hwang, Dong Yeong Kim, Noho Lee, Kyu-Su Kim, Hyunah Kwon, Yong-Tae Kim, Jeong Woo Han, Jong Kyu Kim
Summary: Efficient Ni-based thin film catalysts for the hydrogen evolution reaction in alkaline water electrolysis were studied by incorporating oxophilic transition metal atoms, showing a volcano relation between OH-binding energies and alkaline HER activities. The Cr-incorporated Ni catalyst exhibited optimized binding energies and enhanced HER activity in alkaline media. Introducing 3D Ni nanohelix arrays further improved catalytic performance by providing abundant surface active sites and effective channels for charge transfer and mass transport.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Sang-Mun Jung, Jaesub Kwon, Jinhyeon Lee, Im Kyung Han, Kyu-Su Kim, Youn Soo Kim, Yong-Tae Kim
Summary: A cost-effective nickel-based Thermo-Electrochemical Cell (TEC) with performance comparable to platinum electrodes has been developed in this study, showing potential for commercialization with lower costs.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Physical
Shin-Ae Park, Kyu-Su Kim, Hyun Dong Jung, Sang-Mun Jung, Young Hoon Moon, Seoin Back, Yong-Tae Kim
Summary: This study presents a nanoporous IrRe thin film with an enhanced balance between activity, stability, and conductivity achieved through selective etching of Re, demonstrating a significant improvement in activity-stability factor compared to polycrystalline Ir. The increased electrochemical active surface area and reconstructed structures by electrochemical dealloying of Re contribute to the higher catalytic activities achieved, surpassing state-of-the-art IrO2 catalysts. The unique morphology of a metallic core and an oxide shell also contributes to the higher electronic conductivity of the catalyst.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Odongo Francis Ngome Okello, Kyung-Yeon Doh, Hye Su Kang, Kyung Song, Yong-Tae Kim, Kwang Ho Kim, Donghwa Lee, Si-Young Choi
Summary: Functional h-BN has been prepared by incorporating transition metal impurities like nanoparticles and single atoms. STEM combined with DFT was used to study Ta, Co, Ni, and Ir-decorated h-BN monolayers, showing that Ta atoms are well dispersed while Co, Ni, and Ir atoms form 3D nanoclusters. This study highlights the dynamics of TM/h-BN interaction and provides insight for designing nanostructures for electrocatalytic applications.
Article
Chemistry, Physical
Byung-Jo Lee, Sang-Mun Jung, Jaesub Kwon, Jinhyeon Lee, Kyu-Su Kim, Yong-Tae Kim
Summary: This study introduces titanium carbide (TiC) electrodes as an alternative to platinum (Pt) electrodes for thermoelectrochemical cells (TECs). The TiC-based TECs showed similar power output as Pt-based TECs and demonstrated long-term stability, indicating that TiC can replace Pt as an electrode and promote the commercialization of TECs.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Physical
Sang-Mun Jung, Young Jin Lim, Jaesub Kwon, Kaining Wei, Jinhyeon Lee, Kyu-Su Kim, Sung Gu Kang, Yong-Tae Kim
Summary: It is desirable to gather enormous low-grade waste heat energy using effective thermal energy-harvesting systems. A thermally regenerative electrochemical cycle (TREC) is a reliable approach for converting heat into electricity. In this study, a manganese hexacyanoferrate (MnHCF) is reported as a TREC cathode material with a high temperature coefficient and heat-to-electricity conversion efficiency.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Physical
Kyu-Su Kim, Shin-Ae Park, Hyun Dong Jung, Sang-Mun Jung, Hyunje Woo, Docheon Ahn, Sarah S. Park, Seoin Back, Yong-Tae Kim
Summary: In this study, a nanoporous Ir3Co-core@IrO2-shell electrocatalyst with improved activity and stability was designed. The enhancement in performance was attributed to the residual Co and the three-dimensionally interconnected structure. Under high-current-density conditions, the electrocatalyst provided an ultrafast charge transfer pathway, reducing Ohmic losses.
Article
Chemistry, Physical
Hye Hyeon Han, Sang-Mun Jung, Su-Kyung Kim, Geon-Hui Lee, Seong-Jong Kim, Yong-Tae Kim, Sei Kwang Hahn
Summary: In this study, a bimetallic electrocatalyst of hyaluronate-Au@Pt was synthesized to enhance the oxygen reduction reaction performance of biofuel cells. Hyaluronate, as a biocompatible polysaccharide, was used to improve the dispersibility and stability of the electrocatalyst. The optimized electrocatalyst showed high open circuit voltage and maximum current density, demonstrating its potential in energy generation.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Biochemical Research Methods
Yong Tae Kim, Alireza Ahmadianyazdi, Albert Folch
Summary: Methods using 3D printers to make microfluidic chips have gained much attention for their simple procedures and minimal human intervention. Challenges lie in printing high-resolution chips that are transparent, biocompatible, and contain regions of dissimilar materials. The 'print-pause-print' protocol demonstrates strategies for fabricating transparent biomicrofluidic devices and multimaterial chips. The procedure takes less than 1 hour and enables various chip-based applications.
Correction
Biochemical Research Methods
Yong Tae Kim, Alireza Ahmadianyazdi, Albert Folch
Article
Chemistry, Physical
Noho Lee, Ho Yeon Jang, Kyubin Shim, Sang-Mun Jung, Jinhyeon Lee, Sang-Hoon You, Hye Su Kang, Jong Kyu Kim, Seoin Back, Yong-Tae Kim
Summary: Converting CO2 to useful chemicals using electrocatalytic processes is a promising technology for reducing CO2 levels in the atmosphere. Previous studies on metal-based catalysts have focused on optimizing CO2-reduction reactions but with inefficient and slow reaction kinetics. In this study, an innovative approach using oxophilic metal-incorporated Ag was presented, which facilitated the protonation step of CO2 reduction. The results showed that Co and Ni-incorporated Ag catalysts demonstrated enhanced catalytic performance compared to pure Ag, with high selectivity for CO.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Sang-Mun Jung, Jinhyeon Lee, Jaesub Kwon, Byung-Jo Lee, Seung-Yeon Kang, Kyu-Su Kim, Sang-Hoon You, Young Jin Lim, Sung Gu Kang, Yong-Tae Kim
Summary: Thermo-electrochemical cells (TECs) are being studied as a viable option to harvest waste heat energy. In this study, a tungsten carbide (WCx) electrode was used as a substitute for expensive materials like Pt and nanostructured carbon. This non-noble-metal electrode significantly reduced the cost of the TEC system and delivered an impressive power output. The study demonstrates the potential of WCx as an economical and stable electrode material for waste heat energy harvesting.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Geonwoo Kim, Sang-Mun Jung, Anupam Giri, Jin-Soo Kim, Young-Woo Kim, Kyu-Su Kim, Dongbeom Kim, Yoonsun Choi, Byeong-Joo Lee, Yong-Tae Kim, Unyong Jeong
Summary: In recent years, there has been an increasing demand for hybrid catalysts with heterojunctions between two catalytic materials. Pt and transition metal dichalcogenides (TMDCs) have been the focus for improving electrocatalysts. However, finding a TMDC support for long-term stability of Pt/TMDC hybrid catalysts with high activity remains a challenge. In this study, a hybrid electrocatalyst consisting of ReS2 nanoflowers and Pt nanoclusters (NCs) was presented for efficient hydrogen evolution reaction (HER). The hybrid catalyst exhibited enhanced hydrogen desorption through charge transfer from Pt to ReS2, demonstrating good HER activity, excellent durability, and a low overpotential (20 mV at 10 mA cm-2) compared to conventional Pt/C catalysts.
JOURNAL OF POWER SOURCES
(2023)
Article
Multidisciplinary Sciences
Sang-Hoon You, Sang-Mun Jung, Jinheon Park, Jaerim Kim, Jong Kyu Kim, Junwoo Son, Yong-Tae Kim
Summary: The study focuses on enhancing the durability of fuel cell electric vehicles (FCEVs) during start-up/shutdown (SU/SD) by implementing a metal-insulator transition (MIT) using proton intercalation/deintercalation in WO3. The researchers discover a unique approach that can directly be applied to the mass production process, effectively improving the durability of commercial FCEVs.
Article
Chemistry, Multidisciplinary
Yoona Kim, Sang-Mun Jung, Kyu-Su Kim, Hyun-Yup Kim, Jaesub Kwon, Jinhyeon Lee, Hyun-Seok Cho, Yong-Tae Kim
Summary: This article presents a solution for the electrode degradation problem in alkaline water electrolysis systems. By understanding the degradation mechanism of nickel cathode, it was determined that maintaining the potential of the cathode below 0.6 VRHE can prevent irreversible oxidation and maintain activity for hydrogen evolution reaction. A cathodic protection approach using a sacrificial anode and lead as the sacrificial metal was proposed. The system showed efficient stability and cost effectiveness in alkaline production.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
