Article
Chemistry, Analytical
Pouyan Razmshoar, S. H. Bahrami, Mohammad Rabiee, Marie Hangouet, Marie Martin, Abdelhamid Errachid, Nicole Jaffrezic-Renault
Summary: A label-free immunosensor based on PS-PAMAM dendritic polymer nanofibers was developed for the rapid and sensitive detection of TNF-alpha cytokine. The immunosensor exhibited high affinity towards TNF-alpha with a wide linear range and a low limit of detection.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Amin Moradpour, Manuel Kasper, Johannes Hoffmann, Ferry Kienberger
Summary: This paper presents a comprehensive uncertainty analysis of calibrated electrochemical impedance spectroscopy (EIS) for batteries, aiming to identify the effect of fixture repeatability and measurement noise on the measured impedances. A specific error model is assigned to each uncertainty source, and the model parameters' real and imaginary parts are characterized through impedance measurements. The errors are propagated through the calibration and correction functions, and the resulting uncertainty is shown as ellipsoids in the Nyquist plot.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Engineering, Electrical & Electronic
Leila Es Sebar, Leonardo Iannucci, Emma Angelini, Sabrina Grassini, Marco Parvis
Summary: This article presents a portable low-cost device for electrochemical impedance spectroscopy (EIS) measurements based on TeensyDuino, eliminating the need for additional components. The instrument can measure impedance over a wide frequency range and has a low uncertainty level.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Materials Science, Multidisciplinary
V. Bongiorno, S. Gibbon, E. Michailidou, M. Curioni
Summary: This study explores the potential use of machine learning algorithms to interpret electrochemical impedance spectroscopy (EIS) data, focusing on classification and fitting scenarios. The traditional approach based on equivalent circuit modeling is difficult to automate and has limited industrial applications.
Article
Chemistry, Analytical
Hend S. Magar, Rabeay Y. A. Hassan, Ashok Mulchandani
Summary: Electrochemical impedance spectroscopy (EIS) is a powerful technique for analyzing interfacial properties related to bio-recognition events at the electrode surface, with applications in biomedical diagnosis and environmental monitoring. The use of nanomaterials enhances the analytical features of impedimetric biosensors, promoting faster electron transfer and improving sensor reliability and accuracy.
Article
Energy & Fuels
Mohammad Abareshi, Erfan Sadeghi, Mohsen Hamzeh, Mehrdad Saif, Seyed Mohammad Mahdi Alavi
Summary: This paper proposes a multi-purpose controllable electrochemical impedance spectroscopy (MP-cEIS) device for battery monitoring and testing during charge and discharge processes. The device is based on a synchronous buck converter with a low-cost input filter and includes a closed-loop feedback system for controlling the injection of the EIS excitation signal. The design of a robust controller using H-infinity and quantitative feedback theory (QFT) methods is also presented.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Analytical
Ching-Yu Lin, Uyen Thi Nhat Nguyen, Han-Yun Hsieh, Hidetoshi Tahara, Yu-Sheng Chang, Bing-Yu Wang, Bing-Chen Gu, Yu-Han Dai, Chia-Che Wu, I-Jung Tsai, Yu-Jui Fan
Summary: The study developed a peptide-based electrochemical sensor for detecting autoantibodies in rheumatoid arthritis. The new method showed better sensitivity and accuracy compared to the traditional anti-CCP ELISA method.
Review
Materials Science, Multidisciplinary
Zi-Bo Chen, Hui-Hui Jin, Zhu-Gen Yang, Da-Ping He
Summary: Metal-based nanomaterials have a wide range of applications, and this review focuses on their use in electrochemical impedance spectroscopy (EIS) biosensors for medical healthcare, environmental monitoring, and food safety. The review discusses the importance of bioreceptors and metal nanomaterials in the design and function of these biosensors, and provides insights for future development.
Review
Energy & Fuels
Erfan Sadeghi, Mohammad Mahdi Gholami, Mohsen Hamzeh, Seyed Mohammad Mahdi Alavi, Mehrdad Saif
Summary: With the automotive industry's shift towards electric vehicles and the consequent reliance on energy storage systems, the interest in Power Electronics Interfaced Electrochemical Impedance Spectroscopy (PEI-EIS) is rapidly growing. This paper provides an engineering perspective on the PEI-EIS process, guiding researchers through the main phases, reviewing recent work, and highlighting the challenging issues encountered. It discusses the often overlooked role of the controller, the generation of required excitation signals by power electronics devices, the type of excitations needed, data measurement, and result presentation. Furthermore, it evaluates the pros and cons of past contributions to PEI-EIS from an engineering viewpoint.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Engineering, Electrical & Electronic
Lignesh Durai, Sushmee Badhulika
Summary: The study reported an ultra-selective biosensor for fibrinogen detection using AlFeO3 nanospheres modified screen-printed carbon electrode, which exhibited excellent selectivity and sensitivity. The sensor has a low limit of detection and is suitable for detecting both deficiency and excess levels of fibrinogen in human blood.
IEEE SENSORS JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Naseem Akhtar, Malika Rani, Arshad Mahmood, Kashmala Tariq, G. Murtaza, Asma A. Alothman, Rahaf S. AL-zahrani, Sajid Ali, Naveed Kasuar Janjua, Aqeel Shah
Summary: This work successfully synthesized NaCr2O4/GO nanocomposite using co-precipitation method for energy storage applications. Characterizations such as SEM and XRD were performed to investigate the optical and structural properties. The nanocomposite showed reduced crystalline size and high specific capacitance, making it suitable for various applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Electrochemistry
Samad Nadri, Sayed Habib Kazemi, Leila Nazari
Summary: A novel electrochemical biosensor based on the PCL-PPY-MWCNT electrospun nanofiber was developed for TNF detection, which showed great promise in sensitive and rapid analysis of heart disease prognosis factor.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2022)
Article
Chemistry, Physical
Davood Peyrow Hedayati, Gita Singh, Michael Kucher, Tony D. Keene, Robert Boehm
Summary: This study aims to improve the performance of solid-state supercapacitors (SSCs) by simulating their impedance using a defined equivalent circuit (EC) model. Two models, a mathematical model and a physicochemical model, were used and the impedance was measured using electrochemical impedance spectroscopy (EIS). The physicochemical model showed higher approximation ability due to its more complex circuit design, but also required more modeling and optimization effort.
Article
Engineering, Electrical & Electronic
Ummama Saeed, Batool Fatima, Dilshad Hussain, Shan E. Zahra Jawad, Muhammad Imran, Muhammad Najam-ul-Haq
Summary: Prostate cancer is a leading cause of mortality, and the PSA test has limitations in its reliability. This study shows that electrochemical sensing using lanthanum tungstate nanoflakes can enhance the accuracy of prostate cancer detection by detecting leucine and valine, which are potential diagnostic biomarkers for prostate cancer.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
HuanWen Han, Kazuyuki Nobusawa, Ichiro Yamashita
Summary: The DNA intercalator [Ru(bpy)(2)DPPZ](2+) was found to significantly increase charge transfer in electrochemical impedance spectroscopy (EIS), making it a promising candidate for applications in dsDNA detection or PCR monitoring. Future developments may lead to EIS sensors that do not require specific electrode modifications.
ANALYTICAL CHEMISTRY
(2022)
Correction
Chemistry, Multidisciplinary
Kerstin Gopfrich, Chen-Yu Li, Iwona Mames, Satya Prathyusha Bhamidimarri, Maria Ricci, Jejoong Yoo, Adam Mames, Alexander Ohmann, Mathias Winterhalter, Eugen Stulz, Aleksei Aksimentiev, Ulrich F. Keyser
Article
Chemistry, Organic
Mariia V. Ishutkina, Alice R. Berry, Rohanah Hussain, Olga G. Khelevina, Giuliano Siligardi, Eugen Stulz
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Biochemical Research Methods
Domenico Andrea Cristaldi, Fatih Yanar, Ali Mosayyebi, Pablo Garcia-Manrique, Eugen Stulz, Dario Carugo, Xunli Zhang
Article
Chemistry, Multidisciplinary
Balwinder Kaur, Kamila Malecka, Domenico A. Cristaldi, Clarissa S. Chay, Iwona Mames, Hanna Radecka, Jerzy Radecki, Eugen Stulz
CHEMICAL COMMUNICATIONS
(2018)
Review
Biotechnology & Applied Microbiology
Thomas Mabey, Domenico Andrea Cristaldi, Petra Oyston, Karl P. Lymer, Eugen Stulz, Sandra Wilks, Charles William Keevil, Xunli Zhang
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2019)
Article
Energy & Fuels
Harriet Kimpton, Domenico Andrea Cristaldi, Eugen Stulz, Xunli Zhang
Article
Chemistry, Multidisciplinary
Jonathan R. Burns, James W. Wood, Eugen Stulz
FRONTIERS IN CHEMISTRY
(2020)
Article
Energy & Fuels
Harriet Kimpton, Xunli Zhang, Eugen Stulz
Article
Energy & Fuels
Harriet Kimpton, Eugen Stulz, Xunli Zhang
Article
Biochemistry & Molecular Biology
Kamila Malecka, Balwinder Kaur, D. Andrea Cristaldi, Clarissa S. Chay, Iwona Mames, Hanna Radecka, Jerzy Radecki, Eugen Stulz
Summary: A cobalt-porphyrin modified DNA was used as an electrochemical marker to detect specific DNA sequences, comparing the performance of gold and silver nanoparticles in oligonucleotide sensors. Surprisingly, both types of sensors showed similar overall performance, with direct electron transfer between the porphyrin and the electrode. The silver system displayed better DNA economy and cost-effectiveness compared to gold, making it more suitable for mass production of highly sensitive DNA sensors.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jeffrey Gorman, Sarah R. E. Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A. Panjwani, Yun Liu, Jake L. Greenfield, Simon Dowland, Victor Gray, Sean T. J. Ryan, Sara De Ornellas, Afaf H. El-Sagheer, Tom Brown, Jonathan R. Nitschke, Jan Behrends, Ulrich F. Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard H. Friend, Florian Auras
Summary: This research demonstrates the assembly of pi-conjugated perylene diimides (PDIs) using DNA-encoded approach, allowing precise control over the number of electronically coupled molecules and providing a toolbox for constructing any stacking sequence of these semiconducting molecules. Utilizing a combination of interactions, including DNA guidance, hydrophobic-hydrophilic differentiation, and local geometry and electrostatic interactions, enables efficient molecular stacking with substantial intermolecular pi wave function overlap, leading to an evolution of excited states and triplet formation mechanism.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemical Research Methods
Fabien Hannauer, Rachelle Black, Andrew D. Ray, Eugen Stulz, G. John Langley, Stephen W. Holman
Summary: The fragmentation of oligonucleotides by mass spectrometry allows for sequence determination. Understanding the dissociation mechanisms of oligonucleotides in the gas phase enables the interpretation of data for obtaining sequence information. Recent studies have focused on the fragmentation of modified oligonucleotides, such as locked nucleic acids and modified nucleobases, which hold potential therapeutic interest.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2023)
Review
Chemistry, Analytical
Fabien Hannauer, Rachelle Black, Andrew D. Ray, Eugen Stulz, G. John Langley, Stephen W. Holman
Summary: This review presents the development of oligonucleotide therapeutic drugs and the methods for their analysis and characterization. Ion-pairing reversed-phase liquid chromatography with tandem mass spectrometry is the most commonly used method, but other methods are also available. Research has focused on optimizing the analysis of methylated nucleobases and the development of software for oligonucleotide analysis.
ANALYTICAL SCIENCE ADVANCES
(2022)
Article
Energy & Fuels
Harriet Kimpton, Xunli Zhang, Eugen Stulz
Summary: This study investigated the synthesis and temperature stability testing of three silver-based nanofluids for enhanced efficiency volumetric solar-thermal collectors. Results indicate the need for an appropriate stabilization strategy for a broadband absorber based on silver.
Article
Chemistry, Multidisciplinary
Jeffrey Gorman, Sarah R. E. Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A. Panjwani, Yun Liu, Jake L. Greenfield, Simon Dowland, Victor Gray, Sean T. J. Ryan, Sara De Ornellas, Afaf H. El-Sagheer, Tom Brown, Jonathan R. Nitschke, Jan Behrends, Ulrich F. Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard H. Friend, Florian Auras
Summary: Through DNA-encoded assembly, precise control over the number, sequence, and interactions of semiconductor molecules can be achieved, presenting real opportunities for rapid development of customized semiconductor architectures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
