Article
Chemistry, Analytical
Yu Cai, Tingting Tu, Tianyu Li, Shanshan Zhang, Bin Zhang, Lu Fang, Xuesong Ye, Bo Liang
Summary: The study on the application of nanomaterials in glucose biosensors demonstrates excellent electrochemical performance, taking a step towards the development of the third-generation glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
I. R. Chavez-Urbiola, A. Y. Resendiz-Jaramillo, F. J. Willars-Rodriguez, G. Martinez-Saucedo, L. G. Arriaga, Jesus Alcantar-Pena, Ricardo A. Escalona-Villalpando, J. Ledesma-Garcia
Summary: This study investigates the influence of ZnO semiconductor thin film on enzymatic immobilization in a glucose biosensor. The results suggest that the combination of ZnO thin film and enzymes enhances the immobilization process, leading to improved performance of the glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Alberto G. da Silva-Junio, Isaac A. M. Frias, Reginaldo G. Lima-Neto, Ludovico Migliolo, Patricia S. e Silva, Maria D. L. Oliveira, Cesar A. S. Andrade
Summary: Bacterial and fungal infections pose challenges due to low susceptibility and resistance to antimicrobial drugs. Antimicrobial peptides (AMP) are emerging as excellent alternatives to overcome these problems. This study used a specific AMP called Temporin-PTA (T-PTA) found in the skin secretions of the Malaysian fire frog to develop a biosensor for the electrochemical differentiation of different microorganisms. The biosensor showed promising results with high sensitivity and a linear range for microbial identification.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Ceren Karaman, Onur Karaman, Necip Atar, Mehmet Lutfi Yola
Summary: A novel molecularly imprinted electrochemical biosensor for glucose detection, based on a hierarchical N-rich carbon conductive-coated TNO structure (TNO@NC), has been reported. The biosensor demonstrated high selectivity, sensitivity, and stability in detecting glucose concentrations, making it a potential tool for various applications, including public health and food quality.
Article
Chemistry, Physical
Lu Shen, Zhen Liang, Zhiyu Chen, Can Wu, Xuefeng Hu, Jieyu Zhang, Qing Jiang, Yunbing Wang
Summary: A new concept material, AuNP-PBA nanocomplexes, has been successfully developed by controlled etching of PBA nanocubes and inlaying Au NPs, showing promising applications. Immobilized on a gold wire, it serves as a non-enzymatic glucose sensor with wide linear detection range, excellent anti-interference, and fast response capabilities.
Article
Chemistry, Multidisciplinary
Henglong Xiang, Sijun Huang, Dongwei Zhu, Liqiang Yu, Rui Liu, Yi Guo, Li Xu
Summary: This study confirmed that gold nanoparticles (AuNPs) can accelerate the reaction between [Ag(NH3)(2)](+) and glucose under alkaline conditions, known as the Tollens' reaction, and proposed a possible mechanism. [Ag(NH3)(2)](+) acts as an electron acceptor during glucose oxidation catalyzed by AuNPs, instead of O-2, accompanied by hydrogen transfer. The synthesized silver nanoparticles (AgNPs) can also catalyze this process through a unique cascading catalysis mechanism in the Tollens' reaction. A simple and heatless glucose colorimetric assay is established based on the plasmonic band of AgNPs, with a linear range of 0.6-22.2 μM and a limit of detection of 0.32 μM.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biophysics
Nicole L. Walker, Jeffrey E. Dick
Summary: The development of a new electrochemical technique - open circuit potential, has been aimed at stable and reliable monitoring of biological metabolites. By immobilizing oxidase enzyme in chitosan hydrogel, the method achieves specificity in monitoring metabolites. This approach can effectively detect metabolites such as glucose and can be extended to detect other analytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Xin-Yao Yu, Jun-Yi He, Fei Tang, Peng Yu, Ling Wu, Zhong-Liang Xiao, Li-Xian Sun, Zhong Cao, Donghong Yu
Summary: In this work, a sensor based on molecularly imprinted polymers (MIPs) for l-glutamic acid (l-Glu) was developed through electrochemical polymerization. The optimized reaction conditions resulted in an electrode with excellent catalytic oxidation activity, allowing for the rapid and accurate detection of l-Glu at low concentrations.
ANALYTICAL METHODS
(2023)
Article
Biochemical Research Methods
Muhammet Guler, Adem Zengin, Murat Alay
Summary: This study presents a new electrochemical glucose biosensor that utilizes glucose oxidase (GOx) immobilized on Au@Pd core-shell nanoparticles supported on carboxylated graphene oxide (cGO). The immobilization of GOx was achieved through cross-linking with chitosan biopolymer (CS) and glutaraldehyde (GA) on a glassy carbon electrode. The biosensor exhibited fast response time (5.2 +/- 0.9 s), a satisfactory linear determination range (2.0 x 10(-5) to 4.2 x 10(-3) M), and a low limit of detection (10.4 mu M). Additionally, the biosensor demonstrated good repeatability, reproducibility, and storage stability, with no interference from various analytes.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Electrochemistry
Ricardo J. B. Leote, Elena Matei, Nicoleta G. Apostol, Monica Enculescu, Ionut Enculescu, Victor C. Diculescu
Summary: A nanostructured samarium oxide electrode was prepared by electrodeposition on a gold electrode surface, showing quasi-monodispersed nanoplatelets and coexistence of Sm2+ and Sm3+ species. The electrode displayed improved charge transfer properties and was successfully used for H2O2 detection and glucose biosensing applications with high sensitivity and selectivity.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Wiktoria Lipinska, Katarzyna Siuzdak, Jakub Karczewski, Anna Dolega, Katarzyna Grochowska
Summary: A novel electrode material composed of structured titanium foil with embedded Au nanoparticles and modified with chitosan for glucose detection was presented. The material demonstrated excellent performance with a wide linear range, high sensitivity, and low limit of detection, showing perfect selectivity and stability for biosensing applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Materials Science, Multidisciplinary
Guan-Kai Huang, Shivam Gupta, Chi -Young Lee, Nyan-Hwa Tai
Summary: In this study, a noninvasive saliva glucose sensor was developed using polypyrrole (PPy) and acid-treated carbon nanotubes (acid-CNTs) deposited on a fluorine-doped tin oxide (FTO) conductive glass substrate. The sensor exhibited high sensitivity, selectivity, and stability, making it suitable for noninvasive diagnosis of diabetes.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Materials Science, Biomaterials
Pravin Shende, Pratiksha Sahu
Summary: The research successfully prepared and characterized novel dendrimer-based biosensors for the detection of glucose in saliva. These biosensors showed improved response time and sensitivity, accurately detecting glucose concentration in a short period of time.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Ankur Srivastava, Gargi Mishra, Jay Singh, Mrituanjay D. Pandey
Summary: In this study, nanostructured La2O3 and Au doped La2O3 nanocomposites were prepared hydrothermally and electrophoretically deposited onto ITO glass for the immobilization of tymsinase enzyme. The fabricated Tyr/Au-La2O3/ITO electrode showed promising results for dopamine determination with good sensitivity and reproducibility. Overall, the fabricated electrode could provide an efficient biointerface for the application of rare earth metal oxide nanomaterials in biosensors and bioelectronics.
Article
Engineering, Environmental
Li Zhang, Jia-Qi Fan, Qiong-Qing Zheng, Sai-Jin Xiao, Cheng-Rong Zhang, Shun-Mo Yi, Xin Liu, Wei Jiang, Quan-Gen Tan, Ru-Ping Liang, Jian-Ding Qiu
Summary: In this study, a two-dimensional mesoporous fluorescent covalent organic framework named TY-Hz COF was developed for simultaneous detection and recovery of Au(III). The TY-Hz COF showed rapid and sensitive response to Au(III) with electron transfer-induced fluorescence quenching and visual color change. Moreover, it exhibited excellent adsorption capacity and selectivity towards Au(III). These findings suggest that TY-Hz COF has great potential for Au(III) detection and recovery in e-waste.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Cheng-Rong Zhang, Jia-Xin Qi, Wei-Rong Cui, Xiao-Juan Chen, Xin Liu, Shun-Mo Yi, Cheng-Peng Niu, Ru-Ping Liang, Jian-Ding Qiu
Summary: Researchers have developed a stable carbon material for extracting uranium from seawater. This material demonstrates high selectivity and fast kinetics for uranium adsorption, as well as excellent stability and optoelectronic properties for uranium electroextraction. This work expands the application prospects of functionalized 3D carbon materials and provides technical support for electrodeposition adsorption of uranium from seawater.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Engineering, Chemical
Wei-Rong Cui, Yi-Ru Chen, Wei Xu, Kai Liu, Wei-Bin Qiu, Yibao Li, Jian-Ding Qiu
Summary: A hydroxyl-functionalized 3D covalent organic framework (TAPM-DHBD) with strong fluorescence and 3D interconnected pore channels was synthesized and evaluated for uranium detection and extraction. TAPM-DHBD exhibited exceptional uranium extraction capacity and fast kinetics, with an ultra-low detection limit suitable for sensitive and on-site monitoring of radioactive uranium contamination. Furthermore, TAPM-DHBD showed excellent regenerable performance, providing a new strategy for radioactive contamination monitoring and strategic nuclides extraction.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Li Zhang, Quan-Gen Tan, Jia-Qi Fan, Chen Sun, Yu-Ting Luo, Ru-Ping Liang, Jian-Ding Qiu
Summary: Microfluidic techniques including CE, CEC, and MEKC have been widely used for the chiral separation of biomolecules. Different strategies are employed in these techniques, such as CS-bonded stationary phase in CEC, addition of CS to the mobile phase in CE, and involvement of chiral surfactants and/or CS in pseudostationary phases of MEKC. Microfluidic techniques offer advantages of high selectivity, excellent separation efficiency, and low cost compared to conventional techniques. This review discusses innovations in detection systems, separation mechanism, CS, and chiral analytes of biomolecules, as well as the most applied CSs and the chiral separation of representative biomolecules. Prospects and future developments of microfluidics for chiral separation are also proposed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Shanshan Yu, Chuangye Li, Zifan Li, Fangru Song, Zhenzhen Xu, Yean Zhu, Chunhui Dai, Xiaohong Cao, Zhibin Zhang, Yunhai Liu, Jianding Qiu
Summary: Three novel full-spectrum responsive biomimetic donor-acceptor conjugated microporous polymers were successfully constructed to efficiently photoreduce uranium. The optimized polymers exhibited narrow band gaps, stronger built-in electric fields, and efficient charge separation, achieving a high photocatalytic U(VI) reduction efficiency. This work provides a novel approach for designing high-performance green biomimetic photocatalysts for removing radioactive pollution.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Run-Han Yan, Wei-Rong Cui, Wei Jiang, Juan Huang, Ru-Ping Liang, Jian-Ding Qiu
Summary: In this work, a covalent polymeric network (Py-CPN) based on pyridinium was successfully designed and synthesized, which showed high efficiency and reliability in adsorbing radioactive 99TcO4. This research has significant implications for environmental protection.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Engineering, Environmental
Wei-Rong Cui, Wei Xu, Yi-Ru Chen, Kai Liu, Wei-Bin Qiu, Yibao Li, Jian-Ding Qiu
Summary: In this study, a novel olefin-linked cationic covalent organic framework (COF) BDBI-TMT was synthesized by integrating robust imidazolium salt-based linkers with triazine building blocks, which showed excellent stability in acid/base solutions and radiation. BDBI-TMT exhibited ultra-fast adsorption kinetics and high capture capacity for ReO4- (a non-radioactive surrogate of 99TcO4-), attributed to the abundance of precisely tailored imidazolium salt-based units and the hydrophobicity of the alkyl skeleton. The selective and reversible extraction of ReO4- under extreme conditions demonstrates the great potential of olefin-linked cationic COFs for radionuclide remediation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Qing-Hua Hu, You-Gan Wang, Xin Gao, Yu-Zhen Shi, Sen Lin, Ru-Ping Liang, Jian-Ding Qiu
Summary: Researchers have successfully constructed two isostructural MOFs, NCU-3-X (X = Cl, Br), for efficient adsorption of ReO4-/TcO4- in nuclear waste. NCU-3-Br exhibited superior adsorption performances due to the smaller electronegativity of bromine atoms and the presence of one-dimensional hydrophobic channels in its framework. The adsorption capacity of NCU-3-Br to ReO4-/TcO4- was confirmed through experiments.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Xin Liu, Rui-Xiang Bi, Feng-Tao Yu, Cheng-Rong Zhang, Qiu-Xia Luo, Ru-Ping Liang, Jian-Ding Qiu
Summary: This study synthesized Bi4Ti3O12 (B1) particles, crosslinked B1 with 6-chloro-1,3,5-triazine-diamine (DCT) to obtain B2, and formed B3 using B2 and 4-formylbenzaldehyde (BA-CHO) to investigate its usefulness for photocatalytic UVI removal. B3, with the D-7E-A array structure, effectively reduced UVI to UIV due to energy level matching effects. The UVI removal capacity of B3 under simulated sunlight was 684.9 mg g-1, 2.5 times greater than B1 and 1.8 times greater than B2.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Xiao-Juan Chen, Cheng-Rong Zhang, Xin Liu, Jia-Xin Qi, Wei Jiang, Shun-Mo Yi, Cheng-Peng Niu, Yuan-Jun Cai, Ru-Ping Liang, Jian-Ding Qiu
Summary: Developing ideal adsorbents for efficient and fast uranium extraction has always been a challenge. In this study, a soft three-dimensional covalent organic framework (TAM-DHBD) with a fivefold interpenetrating structure was prepared as a novel porous platform for the efficient extraction of radioactive uranium. TAM-DHBD exhibited exceptional crystallinity, prominent porosity, and excellent chemical stability, allowing for high selectivity and rapid adsorption of uranium.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Chemical
Zhenzhen Xu, Shanshan Yu, Jinyu Wang, Fengtao Yu, Mei Xu, Jianbo Xiong, Saijin Xiao, Yan Liu, Yan He, Jie Xu, Zhibin Zhang, Jianding Qiu
Summary: In this study, a molecular engineering strategy was used to simultaneously achieve high degree of functionalization and large BET in conjugated microporous polymers (CMPs) as an effective uranium adsorbent. The PePy-SO3H adsorbent, which contains a pyrene-based monomer with extended pi-conjugation degree and high rigidity, exhibited strong affinity toward uranium with a distribution coefficient of 2.3 x 104 mL g-1 and an exceptionally high adsorption capacity of 579.0 mg g-1. This work demonstrates the advantages of molecular engineering strategies in optimizing the purification performance of CMPs adsorbents for uranium-containing wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Huaping Peng, Mingchun Lai, Huijing Wang, Zhimin Weng, Yu Yang, Zhongnan Huang, Weiming Sun, Juewen Liu, Wei Chen
Summary: In this study, an energy level engineering strategy was proposed to regulate the electrochemiluminescence (ECL) performance using ligand-protected gold nanoclusters (AuNCs) as luminophores and N,N-diisopropylethylamine (DIPEA) as a coreactant. The energy level matching between the AuNCs and DIPEA effectively promoted electron transfer reactions, improving excitation efficiency and reducing trigger potential. The narrow bandgap of the AuNCs further enhanced emission efficiency. The developed theory was successfully applied to design a highly stable near-infrared ECL system with low trigger potential.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Xin Liu, Rui-Xiang Bi, Zhi-Hai Peng, Lan Lei, Cheng-Rong Zhang, Qiu-Xia Luo, Ru-Ping Liang, Jian-Ding Qiu
Summary: Plasmonic photocatalysis using Bi/Bi2O3_x@COFs as the catalyst effectively removes radioactive uranium from rare earth tailings wastewater. The presence of oxygen vacancy and Schottky potential well in Bi/Bi2O3_x enhances the light absorption performance and electron density of the COFs layer. The synergy between photogenerated electrons and hot electrons enables Bi/ Bi2O3_x@COFs to have high removal capacity and separation coefficient for U(VI). The introduction of localized surface plasmon resonance and Schottky potential well provides a new approach to improve photocatalytic efficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Shun-Mo Yi, Cheng-Rong Zhang, Xin Liu, Wei Jiang, Ru-Ping Liang, Jian-Ding Qiu
Summary: A methyl-rich cationic polymer network (TBT-TCB) was obtained through molecular engineering and successfully applied for the removal of 99TcO4- in harsh environments. The methyl groups in TBT-TCB greatly enhance its resistance to strong acid/alkali, and also improve its hydrophobicity for better affinity towards 99TcO4-. TBT-TCB exhibits excellent robustness, reusability, adsorption selectivity, and adsorption kinetics for 99TcO4-/ReO4-.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Li Zhang, Chen Sun, Sai-Jin Xiao, Quan-Gen Tan, Gui-Ping Yang, Jia-Qi Fan, Yu-Ting Luo, Ru-Ping Liang, Jian-Ding Qiu
Summary: Sulfur mustard (HD) is a highly toxic substance, and exploring efficient catalysts for its degradation is of great significance. Covalent organic frameworks (COFs) as photocatalysts show great potential in HD decontamination. In this study, a photosensitive COF was constructed and silver nanoparticles were deposited on it through postmodification, resulting in enhanced photocatalytic degradation performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)