Correction
Chemistry, Multidisciplinary
Latif Ullah, Guoying Zhao, Zichen Xu, Hongyan He, Muhammad Usman, Suojiang Zhang
Summary: A correction is needed for Figure 9 in the publication referenced above.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Organic
Jodie L. Hann, Catherine L. Lyall, Gabriele Kociok-Kohn, Simon E. Lewis
Summary: This study presents a method for the synthesis of N-alkoxycarbonyl pyrroles by the condensation of readily available O-substituted carbamates with 2,5-dimethoxytetrahydrofuran. It is demonstrated that N-alkoxycarbonyl protection can impart distinct reactivity to pyrrole in comparison with N-sulfonyl protection.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ching-Bin Ke, Ru-Yu Yan, Jian-Lian Chen
Summary: The molecularly imprinted HCP has a mesoporous structure and excellent fluorescence properties. It shows linear fluorescent intensity with TA concentration, and exhibits good selectivity and sensitivity.
Article
Chemistry, Physical
Mingyao Li, Shuyao Zhou, Shizhao Ren, Lei Zhang, Bing Yin, Cong Zhao, Zhirong Liu, Chuancheng Jia, Xuefeng Guo
Summary: Controllable edge-selective modification and tailoring of graphene were achieved by a solvent-controlled acylation reaction, enabling precise functionalization and size adjustment. The introduction of carboxyl groups to the graphene edge provides new reaction sites for further modification, while the acylation process can tear graphene into highly dispersed quantum dots of desired size, expanding the potential applications of graphene.
Article
Chemistry, Applied
Haeun Park, Sunwoo Lee
Summary: The Friedel-Crafts acylation reaction was conducted between activated amides and arenes using [Pd(cinnamyl)Cl](2) and Cu(OTf)(2) as catalysts. A variety of N-phenyl-N-tosylbenzamides with substituted phenyl rings underwent reactions with different arenes, including mesitylene, toluene, anisole, 4-tert-butylbenzene, o-xylene, m-xylene, and p-xylene, resulting in the corresponding diaryl ketones with yields ranging from 49% to 89%.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Lisa Goclik, Henrik Walschus, Alexis Bordet, Walter Leitner
Summary: A versatile synthetic pathway has been developed for the production of valuable alkyl phenols and anilines. The immobilized bimetallic iron ruthenium nanoparticles on an imidazolium-based supported ionic liquid phase (Fe25Ru75@SILP) serve as highly active and selective catalysts for the deoxygenation of the side-chain without hydrogenation of the aromatic ring. The catalytic system allows operation under continuous flow conditions with high robustness and flexibility.
Article
Engineering, Environmental
Wen-Hui Hu, Meng-Nan Liu, Qun-Xing Luo, Jianbo Zhang, Huiyong Chen, Long Xu, Ming Sun, Xiaoxun Ma, Qing-Qing Hao
Summary: This study investigates the influence of microscale structure of MWW zeolites on the kinetics for acylation of anisole with acetic anhydride. It is found that the acylation reaction occurs solely on the external acid sites of MWW zeolites, and the single-layer MWW (SL-MWW) exhibits higher recycle stability compared to the multiple-layer MWW (ML-MWW). The confinement effect within 12MR pockets on the surface of SL-MWW results in difficult desorption of product and small rate constant.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Yehezkiel Steven Kurniawan, Arif Cahyo Imawan, Yoeretisa Miggia Stansyah, Tutik Dwi Wahyuningsih
Summary: A simple and efficient method for synthesizing acetophenone derivatives using PdO-activated bentonite as a heterogeneous catalyst was successfully developed. The synthesis of acetophenone derivatives with various substituents at the para position achieved high yields under optimal conditions. The catalysis mechanism was proposed to be mainly facilitated by the acid sites of the PdO-activated bentonite catalyst, which showed good recyclability and environmental friendliness.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Organic
Kaikai Wang, Rong Zeng
Summary: This study presents a photoinduced iron catalysis that efficiently cleaves C-C bonds and brominates or iodinates unstrained tertiary cycloalkanols using NBS/NIS. The reaction demonstrates good functional group tolerance and high yields under mild conditions, providing a powerful tool for the synthesis of remote halogenated alkyl ketones. The resulting products can be further converted to valuable molecules through nucleophilic substitution or cross-coupling reactions.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
Pedro Leo, Neus Crespi, Carlos Palomino, Antonio Martin, Gisela Orcajo, Guillermo Calleja, Fernando Martinez
Summary: Sulfonic-containing UiO-66 and MIL-101 MOF materials synthesized with a sulfonic acid linker exhibited good acid catalytic activity in the Friedel-Crafts acylation reaction. MIL-101-SO3H material, with its open structure and multimodal pore size distribution, showed remarkable anisole conversion and specific activity per sulfonic acid centre. It also demonstrated easy recovery and reusability without loss of activity, making it a promising alternative catalyst for acid-catalyzed reactions.
Article
Chemistry, Physical
Han K. Chau, Daniel E. Resasco, Phuong Do, Steven P. Crossley
Summary: The Friedel-Crafts acylation of phenolic compounds with carboxylic acids catalyzed by Bronsted-acid zeolites is an interesting reaction with potential applications in renewable fuels and chemicals production. The study evaluated the reaction under varying conditions over H-ZSM-5 catalysts, revealing that in diffusion-limited conditions, the kinetics of the reaction are significantly influenced.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Inorganic & Nuclear
Guofang Gao, Qian Zhao, Cheng Yang, Tingshun Jiang
Summary: A novel bismuth SBA-16 catalyst was synthesized and four imidazole ionic liquids were successfully functionalized on Bi(10)-SBA-16 silicon mesoporous material for catalyzing the acylation reaction of anisole with acetic anhydride. Experimental design revealed that 1.2ILc@Bi(10)-SBA-16 exhibited good catalytic activity and stability under specific conditions.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Organic
Shoko Nagahata, Seiya Takei, Satoshi Ueno
Summary: In this study, gamma-phenyl-beta,gamma-unsaturated ketones were synthesized in situ and reacted with alpha,beta-unsaturated carbonyls to form tri- or diarylated benzophenones in a one-pot manner.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xinghui Lyu, Ryuhei Kanda, Susumu Tsuda, Yoshiya Hashimoto, Takamasa Fujii, Kosuke Kashiwagi
Summary: This study successfully carboxylated PEEK sample surfaces using Friedel-Crafts acylation and investigated the possibility of further chemical modifications. The results suggest that a series of reactions can be employed to impart desired chemical structures to PEEK surfaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Guilherme Pazini Abatti, Idejan Padilha Gross, Thiago F. da Conceicao
Summary: The study demonstrates the synthesis and characterization of poly(ether sulfone) Udel (R) (PSU-Udel) derivatives through post-polymerization Friedel-Crafts acylation, with different acylation degrees and side groups. The results show that the thermal and mechanical properties of PSU can be adjusted by post-polymerization acylation, with potential for specific applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
Jin-Tai Lin, Tzu-Chi Chu, Deng-Gao Chen, Zhi-Xuan Huang, Hsiao-Chien Chen, Chia-Shuo Li, Chih- Wu, Pi-Tai Chou, Ching-Wen Chiu, Hao Ming Chen
Summary: This study presents a novel p-n junction configuration in the light-absorbing layer of tin perovskite solar cells, leading to a significant performance enhancement for HTM-free Sn PSCs, achieving high power conversion efficiency and excellent long-term stability.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jiali Wang, Hsiao-Chien Chen, Hui-Ying Tan, Cher Ming Tan, Yanping Zhu, Hao Ming Chen
Summary: This article focuses on the variations in surface chemical state under working conditions in CO2RR and systematically summarizes the regulation of chemical state and its relation to product profile in catalysts with varying metal centers. The debates over the effects of chemical state on product profile during CO2RR are also discussed. The study highlights the importance of surface chemical state sensitivity to product profile during CO2RR.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Electrochemistry
Shih-Chieh Hsu, Han-Hsin Chiang, Tzu-Yen Huang, Szu-Han Chao, Rudder T. Wu, Cheng-Zhang Lu, Jen-Hsien Huang, Cai-Wan Chang-Jian, Huei Chu Weng, Hsiao-Chien Chen
Summary: In this article, a series of single-phase NixMn1-x(OH)2 hydroxides with different chemical compositions were synthesized, and the effect of chemical composition on the capacitive characteristics was investigated. The results showed that Ni3/4Mn1/4(OH)(2) hydroxide exhibited the best electrochemical performance and when used in asymmetric supercapacitors with active carbon, it showed a high energy density and remarkable cycling life.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Huachuan Sun, Ching-Wei Tung, Yang Qiu, Wei Zhang, Qi Wang, Zhishan Li, Jiang Tang, Hsiao-Chien Chen, Chundong Wang, Hao Ming Chen
Summary: Real bifunctional electrocatalysts for water splitting should exhibit steady configuration without irreversible structural transformation or surface reconstruction. Through strong metal-support interaction, single-atom dispersed Ru catalysts decorating onto nickel-vanadium LDH scaffold show excellent HER and OER activities without the need for reconstruction. The proposed Ru/Ni3V-LDH is a stable bifunctional electrocatalyst with strong metal-support interaction, suitable for catalyzing water splitting reactions effectively.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Fu-He Hsiao, Cheng-Chu Chung, Chun-Hao Chiang, Wei-Neng Feng, Wen-Yen Tzeng, Hung-Min Lin, Chien-Ming Tu, Heng-Liang Wu, Yu-Han Wang, Wei-Yen Woon, Hsiao-Chien Chen, Ching-Hsiang Chen, Chao-Yuan Lo, Man-Hong Lai, Yu-Ming Chang, Li-Syuan Lu, Wen-Hao Chang, Chun-Wei Chen, Chih-Wei Luo
Summary: The adsorption and desorption of electrolyte ions significantly influence the carrier density and type on the surface of monolayer-MoS2 catalyst during the hydrogen evolution reaction. The accumulation of electrolyte ions on the surface of monolayer MoS2 can lead to the formation of excitons and trions. By using the distinct carrier relaxation dynamics of excitons and trions, an in situ microcell-based scanning time-resolved liquid cell microscope is established to investigate the catalytic activity of monolayer MoS2 during the hydrogen evolution reaction.
Article
Chemistry, Multidisciplinary
Yuan Pan, Xuelu Ma, Minmin Wang, Xuan Yang, Shoujie Liu, Hsiao-Chien Chen, Zeweng Zhuang, Yanhui Zhang, Weng-Chon Cheong, Chao Zhang, Xing Cao, Rongan Shen, Qian Xu, Wei Zhu, Yunqi Liu, Xingdong Wang, Xuejiang Zhang, Wensheng Yan, Jun Li, Hao Ming Chen, Chen Chen, Yadong Li
Summary: A coupling catalyst with highly dispersed N, P co-doped carbon frames anchored with Fe single atoms and Fe2P nanoparticles has been synthesized for the electrocatalytic oxygen reduction reaction. The optimized catalyst shows superior activity and stability in acidic and alkaline media, and theoretical calculations reveal a synergistic effect of Fe2P and doped P atoms. The study provides a novel idea for constructing high-efficiency ORR electrocatalysts with atomic-level precision.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xing Cao, Aijian Huang, Chao Liang, Hsiao-Chien Chen, Tong Han, Rui Lin, Qing Peng, Zewen Zhuang, Rongan Shen, Hao Ming Chen, Yi Yu, Chen Chen, Yadong Li
Summary: This study reports reversible photochromic BiOBr nanosheets (p-BiOBr) that can change colors by trapping photogenerated holes and bleached by water oxidation to generate hydroxyl radicals, demonstrating enhanced carrier separation and water oxidation. Efficient photocatalytic coupling and oxidation reactions of ethylbenzene can be achieved by p-BiOBr in a water-based medium. The p-BiOBr nanosheets feature lattice disordered defects on the surface, which provide abundant uncoordinated catalytic sites and induce structural distortions and lattice strain, resulting in altered band structure and significantly enhanced photocatalytic performances.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ying-Rui Lu, Hsiao-Chien Chen, Kang Liu, Min Liu, Ting-Shan Chan, Sung-Fu Hung
Summary: This study utilizes egg white to prepare single-atom electrocatalysts and discovers their excellent activity in the oxygen reduction reaction. Through research, the electron transfer mechanism and interaction with oxygen in the single-atom electrocatalysts are revealed, providing new insights for waste transformation and sustainable development.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Huachuan Sun, Linfeng Li, Hsiao-Chien Chen, Delong Duan, Muhammad Humayun, Yang Qiu, Xia Zhang, Xiang Ao, Ying Wu, Yuanjie Pang, Kaifu Huo, Chundong Wang, Yujie Xiong
Summary: This study reports a multifunctional electrocatalyst, Rh/NiV-LDH, which integrates NiV-LDH and Rh single-atom catalyst for efficient urea electrolysis and hydrogen fuel generation. The electrocatalyst demonstrates excellent activity in both HER and urea oxidation reactions, indicating its potential for wastewater purification and energy conversion. The research provides important insights and references for multifunctional SAC design.
Article
Multidisciplinary Sciences
Xuefei Xu, Qingming Deng, Hsiao-Chien Chen, Muhammad Humayun, Delong Duan, Xia Zhang, Huachuan Sun, Xiang Ao, Xinying Xue, Anton Nikiforov, Kaifu Huo, Chundong Wang, Yujie Xiong
Summary: The study demonstrates that metal-organic frameworks (MOFs) can serve as an ideal platform for tailoring active sites to enhance the urea oxidation reaction. Specifically, a MOF based on Ni/Mn sites and terephthalic acid ligands exhibits low voltage and high turnover frequency, achieving efficient urea degradation.
Article
Chemistry, Multidisciplinary
Xuefei Xu, Hsiao-Chien Chen, Linfeng Li, Muhammad Humayun, Xia Zhang, Huachuan Sun, Damien P. Debecker, Wenjun Zhang, Liming Dai, Chundong Wang
Summary: Metal-organic frameworks (MOFs) have potential in electrocatalysis due to their adjustable ligand structures, but their poor stability hinders practical applications. This study introduces an innovative strategy of leveraging metal nodes to enhance both the catalytic activity and stability. The NiRh-MOF||NiRh-MOF configuration in the electrolysis cell achieved a current density of 10 mA cm(-2) at an ultralow voltage of 0.06 V in alkaline seawater, outperforming the Pt/C||Pt/C benchmark cell (0.12 V). Additionally, the incorporation of Rh into the MOF enabled a robust stability of over 60 hours in seawater electrolyte.
Article
Chemistry, Multidisciplinary
Chia-Jui Chang, Yi-An Lai, You-Chiuan Chu, Chun-Kuo Peng, Hui-Ying Tan, Chih-Wen Pao, Yan-Gu Lin, Sung-Fu Hung, Hsiao-Chien Chen, Hao Ming Chen
Summary: We demonstrated a model system of Lewis acidic supported Cu electrocatalyst with a pulsed electroreduction method to achieve enhanced performance for C2+ products, and found that the presence of Zn5+O species under the cathodic potential effectively served as a Lewis acidic support for preserving the Cu5+O species to facilitate the formation of C2+ products. The catalyst structure-property relationship of Cu5+O/Zn5+O interfaces was realized and the stabilizing Cu5+O species was found to be universal for various metal oxide supports.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Gaoyan Xiong, Chao Feng, Hsiao-Chien Chen, Junxi Li, Fei Jiang, Shu Tao, Yunxia Wang, Yichuan Li, Yuan Pan
Summary: This study adopts a facile and effective in situ encapsulation-oxidation strategy for constructing a coupling catalyst composed of atomically dispersed Pt-doped Co3O4 spinel nanoparticles (NPs) embedded in polyhedron frames (PFs) for robust propane total oxidation. The optimized catalyst exhibits excellent propane catalytic activity with low T-90 and superior reaction rate, activation energy, and turnover frequency. The doping of Pt atoms enhances oxygen activation ability and decreases the energy barrier required for C-H bond breaking, improving the deep oxidation process.
Article
Chemistry, Multidisciplinary
Yen-Po Huang, Ching-Wei Tung, Tai-Lung Chen, Chia-Shuo Hsu, Mei-Yi Liao, Hsiao-Chien Chen, Hao Ming Chen
Summary: This study systematically designed a series of pre-electrocatalysts to explore the correlation between the dynamic characterization of Cu sites in the presence of Zn/ZnO and the product profile. The research found that the recrystallized Cu site with a lower coordination number exhibited a preferential production of CH4, providing a promising approach for the efficient production of CH4.
Article
Chemistry, Physical
Ching-Wei Tung, Yu-Ping Huang, Chia-Shuo Hsu, Tai-Lung Chen, Chia-Jui Chang, Hao Ming Chen, Hsiao-Chien Chen
Summary: Transition metal phosphides combined with heteroatoms to manufacture bimetallic phosphides can enhance the electrocatalytic performance in hydrogen evolution reaction. The synergistic effect between Co sites and metallic Ru in Ru-x@CoP catalyst was investigated, and the optimal Ru-1.2@CoP showed the highest catalytic activity. The formation of new Co-Ru bonds during the HER process was discovered, which suppressed the formation of metallic Co and dominated the catalytic behavior.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
