Article
Engineering, Electrical & Electronic
Guilherme Sampaio, Felipe Oliveira Barino, Alexandre Bessa dos Santos
Summary: This paper presents a novel method for the interrogation of LPFG sensors using harmonic analysis of the optical power reflected by an FBG attached to a vibrating piezoelectric component.
OPTICAL FIBER TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Luis Henrique Silva, Paulo Santos, Luis C. C. Coelho, Pedro Jorge, Jose Manuel Baptista
Summary: The paper presents the development of an interrogation system for long period fiber gratings using the temperature response of a multimode laser diode. By performing a spectral sweep and curve fitting technique, high-precision measurements can be achieved at a lower cost compared to typical interrogation systems.
Article
Optics
Kerong Jiao, Hua Shen, Feiyan Yang, Xuecheng Wu, Yinxu Bian, Rihong Zhu
Summary: This study successfully alleviated the main issue of spectral broadening in fiber lasers using phase-shifted long-period fiber gratings, providing a new method for optimizing the output spectral linewidth of lasers.
OPTICS AND LASER TECHNOLOGY
(2021)
Review
Optics
Chao Du, Qiuyu Wang, Shuang Zhao, Xiao Deng
Summary: In this paper, biosensors based on long period fiber grating (LPFG) are reviewed, focusing on sensing mechanisms, signal demodulation, fabrication, and recent developments. The applications of LPFG biosensors in the detection of various substances such as glucose, bacteria, immunoglobulins, biotin, DNA, hemoglobin, viruses, and drugs are classified and summarized. The challenges in practical applications, such as temperature cross-sensitivity and stable wavelength demodulation, are also mentioned, and possible solutions are proposed. The future development of biosensors is discussed as well.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
Xingliu Hu, Haifei Si, Hao Shen
Summary: A new distributed demodulation system based on space division multiplexing is proposed for multi-point detection of long period fiber grating pairs. The system combines traditional spectrometer demodulation with computer technology, utilizing optical switches to achieve spectrum reduction, resonant wavelength, and temperature demodulation of the LPGP. The system demonstrates a fast demodulation speed of 1.1s and high wavelength accuracy of 0.01 nm, with advantages of high precision, strong compatibility, and user-friendly operation interface.
Article
Engineering, Electrical & Electronic
Zihan Cao, Titi Xia, Shengqi Zhang, Shuhe Zhang, Yongchang Mei, Zhengyong Liu, Tuan Guo, Zhaohui Li
Summary: This paper proposes a new approach using residual blocks and convolutional neural networks for demodulating the spectra of tilted fiber Bragg grating based refractive-index sensors. The results show that the proposed method achieves high accuracy and generalization capability. Additionally, the method demonstrates the potential to reduce the cost of interrogation hardware.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Yiwei Ma, Min Zhao, Chunbo Su, Jing Sun, Xiaofei Li, Ze Yu, LiLi Zhang, Tao Geng
Summary: This paper experimentally proposes and theoretically investigates a two-dimensional vector curvature sensor based on asymmetrically polished long period fiber grating (AP-LPFG). The sensor, fabricated using a high-frequency CO2 laser, enhances the bending sensitivity by polishing periodic asymmetrical V-shaped grooves on a single mode fiber (SMF). The experimental results demonstrate high sensitivity and temperature response, suggesting the potential of this sensor in curvature sensing applications.
Article
Engineering, Electrical & Electronic
Yiwei Ma, Chunbo Su, Zizhao Dai, Tian Tian, Xinghua Yang, Tao Geng, Libo Yuan
Summary: In this paper, a novel type of long period fiber grating with two resonant peaks is theoretically analyzed and experimentally verified. The proposed sensor exhibits high sensitivity to refractive index (RI) measurement. The experimental results show that the sensor has a high RI sensitivity and can be used for temperature and RI measurement simultaneously.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Hongchang Deng, Rui Wang, Xiaowen Jiang, Chuanxin Teng, Ronghui Xu, Yu Cheng, Wentao Zhang, Libo Yuan
Summary: A high sensitivity long-period fiber grating sensor was proposed for strain and temperature detection, which is insensitive to refractive index change but highly sensitive to stress and temperature. Experimental results showed that the sensor achieved a strain sensitivity of -9.29 pm/mu epsilon and a temperature sensitivity of 17.14 pm/degrees C. The sensor's sensing characteristics are related to the hollow air capillary diameter and twisting pitch of the helical capillary optical fiber.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Sunil Kumar, Swapan Kumar Ghorai, Somnath Sengupta
Summary: This article proposes a Fiber Bragg Grating (FBG) peak detection method using the edge-filtering technique and a Long Period Grating (LPG)-modulated light source. The LPG with low loss-band and linear intensity variation within a certain wavelength range is chosen. The broadband light source is passed through the LPG and split using a 3 dB coupler. The modulated light is fed separately to two FBG using Y-couplers. The reflected lights from FBG are measured using an optical power meter. The proposed method is simple, dynamic, and cost-effective, and has been experimentally implemented for strain and temperature measurement with corresponding sensitivities of 1.01 pm/με and 9.8 pm/℃.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Computer Science, Information Systems
Cailing Fu, Pengfei Li, Zhiyong Bai, Yiping Wang
Summary: A high-quality helical long period fiber grating (HLPFG) was successfully demonstrated in elliptical core polarization-maintaining fiber (PMF) using hydrogen-oxygen flame heating technique. The single HLPFG with a length of 6.5 mm could generate orbital angular momentum (OAM) modes. The success in generating OAM(+/- 2) mode is attributed to the two-fold symmetry of the elliptical core PMF in the cross-section.
Article
Optics
Pengfei Tian, Weihong Bi, Xiaoyu Wang, Wa Jin, Baojun Zhang, Xinghu Fu, Guangwei Fu
Summary: This paper introduces a new type of long period fiber grating mode converter based on hybrid dual-core fiber, which can convert LP01 mode to LP21 and LP02 with purity up to 98% after conversion.
Article
Engineering, Electrical & Electronic
Liliana M. Sousa, Joana Vieira, Margarida Facao, Gil M. Fernandes, Rogerio Nogueira, Ana M. Rocha
Summary: This work proposes a novel technique to couple light from a single-mode fiber to all cores of a multi-core fiber, demonstrated through numerical simulations. By reducing the cladding radius and inscribing identical LPGs in the MCF cores, the proposed device successfully improves the pumping efficiency of MCF amplifiers.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Review
Chemistry, Analytical
Jintao Cai, Yulei Liu, Xuewen Shu
Summary: Optical fiber biosensors (OFBS) are proposed as a superior alternative to conventional sensors due to their compactness, remote control capabilities, and immunity to electromagnetic interference. This review presents the advancements of OFBS based on long-period fiber gratings (LPFGs) in chemical and biomedical applications, focusing on design and functionalization. Enhancing the sensor sensitivity can be achieved through device design near the dispersion turning point or mode transition, as well as their combination. Various functionalization methods, both covalent and non-covalent, are summarized, including the immobilization of APTES silanization and GO functionalization. Additionally, different configurations of reflective LPFG-based sensors are also introduced. This work provides a comprehensive understanding of LPFG-based biosensors and suggests potential future research directions.
Article
Engineering, Electrical & Electronic
Tanoy Kumar Dey, Palas Biswas, Nandini Basumallick, Somnath Bandyopadhyay
Summary: The add-layer sensitivity of long-period fiber grating (LPFG) near mode transition (MT) for a highly sensitive LPFG-based biosensing probe was studied in reflection configuration. The sensitivity was found to depend on the separation between resonant cladding modes considered during MT. The mode stretched LPFG (MSLPFG) probe was formed by cleaving the LPFG with precisely increased or stretched separation between two consecutive cladding modes, and an electrostatic self-assembled (ESA) polymeric overlay was deposited on the grating surface to enhance sensitivity and eliminate multiple resonant bands.
IEEE SENSORS JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Joe Gerald Jesu Raj, Marta Quintanilla, Khaled A. Mahmoud, Andy Ng, Fiorenzo Vetrone, Mohammed Zourob
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Chemistry, Analytical
Gaston Contreras Jimenez, Shimaa Eissa, Andy Ng, Hani Alhadrami, Mohammed Zourob, Mohamed Siaj
ANALYTICAL CHEMISTRY
(2015)
Article
Nanoscience & Nanotechnology
Teresa Simao, Andy Ng, Dorothy Fatehi, Slavisa Corluka, Abedelnasser Abulrob, Mohammed Zourob
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2015)
Article
Multidisciplinary Sciences
Huiyan Li, Jeffrey D. Munzar, Andy Ng, David Juncker
SCIENTIFIC REPORTS
(2015)
Article
Chemistry, Multidisciplinary
Jeffrey D. Munzar, Andy Ng, Mario Corrado, David Juncker
Article
Multidisciplinary Sciences
Jeffrey D. Munzar, Andy Ng, David Juncker
NATURE COMMUNICATIONS
(2018)
Article
Nanoscience & Nanotechnology
Chiheb Esseghaier, Ghadeer A. R. Y. Suaifan, Andy Ng, Mohammed Zourob
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2014)
Article
Nanoscience & Nanotechnology
Milad Dagher, Michael Kleinman, Andy Ng, David Juncker
NATURE NANOTECHNOLOGY
(2018)
Article
Materials Science, Multidisciplinary
Edward N. Zhang, Jean-Pierre Clement, Alia Alameri, Andy Ng, Timothy E. Kennedy, David Juncker
Summary: Brain implants are increasingly used for neurological disorders treatment, but the mismatch between their Young's modulus and brain tissue exacerbates the foreign body response. The study introduces mechanically matched brain implants (MMBI) made from silicone, fabricated using new methods and a dissolvable sugar shuttle for reliable implantation. MMBIs show higher neuronal density and lower FBR near the tissue-implant interface compared to traditional implants, indicating improved functionality and reliability.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Frederic Normandeau, Andy Ng, Maiwenn Beaugrand, David Juncker
Summary: Antibody microarrays for multiplexed protein detection have shown lack of reproducibility due to spatial bias across glass slides. Different layouts of spot replicates were evaluated, with structured random replicates providing the most accurate estimation of assay variation. The study recommends detailed characterization of spatial bias and the use of distributed positive replicates in research and clinical applications.
Article
Multidisciplinary Sciences
Mohamed Yafia, Oriol Ymbern, Ayokunle O. Olanrewaju, Azim Parandakh, Ahmad Sohrabi Kashani, Johan Renault, Zijie Jin, Geunyong Kim, Andy Ng, David Juncker
Summary: This article introduces microfluidic chain reactions as a structured propagation of capillary flow events. Monolithic chips integrating microfluidic chain reactions are printed in three dimensions and powered by the free energy of a paper pump to autonomously execute liquid handling algorithms. Microfluidic chain reactions have wide-ranging applications in liquid handling and point-of-care diagnostics.
Article
Gastroenterology & Hepatology
Zijie Jin, Andy Ng, Corinne F. Maurice, David Juncker
Summary: MiCoMo is a low-cost, benchtop multi-bioreactor system that simulates the human colon environment, allowing for the study of gut microbial communities with high throughput and multiplexing capabilities.
Article
Biochemical Research Methods
Azim Parandakh, Oriol Ymbern, William Jogia, Johan Renault, Andy Ng, David Juncker
Summary: Researchers have developed a novel chip-based ELISA technology that enables rapid and highly sensitive antibody detection. The chip simplifies chip loading and pipetting through autonomous aliquoting functionality, and can accommodate higher surfactant concentrations. The ELISA chip can complete the assay in 1.5 hours and exhibits comparable accuracy and performance to central laboratory ELISA.
Review
Chemistry, Multidisciplinary
Jeffrey D. Munzar, Andy Ng, David Juncker
CHEMICAL SOCIETY REVIEWS
(2019)
Article
Chemistry, Analytical
Ayokunle Oluwafemi Olanrewaju, Andy Ng, Philippe DeCorwin-Martin, Alessandra Robillard, David Juncker
ANALYTICAL CHEMISTRY
(2017)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)