期刊
BIOSENSORS & BIOELECTRONICS
卷 36, 期 1, 页码 154-160出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.04.005
关键词
Thiol-ene chemistry; Polypyrrole; Carboxylated thiols; Multiwalled carbon nanotubes; Dopamine electroanalysis
类别
资金
- National Natural Science Foundation of China [21175042, 21075036, 21105026, 20875029]
- Foundation of the Hunan Provincial Education Department
- Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
- State Key Laboratory of Chemo/Biosensing and Chemometrics [200902]
- State Key Laboratory of Electroanalytical Chemistry
We report on the thiol-ene chemistry guided preparation of novel thiolated polymeric nanocomposite films of abundant anionic carboxylic groups for electrostatic enrichment and sensitive electroanalysis of cationic dopamine (DA) in neutral solution. Briefly, the thiol-ene nucleophilic reaction of a carboxylated thiol with oxidized polypyrrole (PPy), which was electrosynthesized on an Au electrode in the presence of solution-dispersed acidified multiwalled carbon nanotubes (MWCNTs), produced an a PPy-thiol-MWCNTs/Au electrode, and the PPy can be electrochemically overoxidized (OPPy) to form an OPPy-thiol-MWCNTs/Au electrode. The carboxylic groups of the polymeric nanocomposite film originate from the acidified MWCNTs, PPy-tethered carboxylated thiol, and OPPy. The carboxylated thiols examined are mercaptosuccinic acid (MSA) and thioglycolic acid, with beta-mercaptoethanol as a control. Electrochemical quartz crystal microbalance, scanning electron microscopy, Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy were used for film characterization and process monitoring. Under the optimized condition, the differential pulse voltammetry peak current of DA oxidation at OPPy-MSA-MWCNTs/Au electrode is linear with DA concentration from 1.00 x 10(-9) to 2.87 x 10(-6) mol L-1, with a limit of detection of 0.4 nmol L-1, good anti-interferent ability and stability. (C) 2012 Elsevier B.V. All rights reserved.
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