Article
Spectroscopy
Shuyan Xiao, Jiping Lu, Liang Sun, Shengli An
Summary: A new colorimetric biosensor for specific detection of azlocillin was developed using DNA aptamer and unmodified gold nanoparticles. The biosensor showed a red solution in the absence of azlocillin and a color change from red to blue in the presence of azlocillin. The biosensor exhibited a linear relationship with a detection limit of 11.6 nM and was successfully used to detect azlocillin in milk and tap water samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Swati Tanwar, Vishaldeep Kaur, Gagandeep Kaur, Tapasi Sen
Summary: Engineering hotspots in surface-enhanced Raman spectroscopy (SERS) by precisely controlling the assembly of plasmonic nanostructures can enhance the potential of SERS for single molecule detection. Plasmonic dimer nanoantennas with tunable gaps showed significant enhancements for single dye molecules, and were able to detect a single thrombin protein molecule in a 10 nm wide nanogap. These engineered nanoantennas have the potential to serve as a broadband SERS enhancer for specific detection of biological molecules with single-molecule sensitivity.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Shan Lin, Jiangyan Zhong, Yuwu Chi, Yipeng Chen, Malik Saddam Khan, Jianzhen Shen
Summary: Micro-sized glassy carbon microspheres were used as signal markers for the first time, showing 3 times higher sensitivity in detecting PSA compared to nano-sized gold nanoparticles. The development of GCM-based ICTSs have promising applications in sensitive immunoassay, with carboxyl groups on the surface of GCMs enabling qualitative and quantitative determination of PSA in immunochromatographic test strips.
Article
Chemistry, Analytical
Dongmiao Qin, Shuo Meng, Yusheng Wu, Guichun Mo, Biyang Deng
Summary: In this study, gold nanoclusters (AuNCs) were wrapped with 6-aza-2-thiothymine (ATT) to induce the electrochemiluminescence (ECL) enhancement of AuNCs. A new dual-quenching ECL immunosensor based on ATT-AuNCs luminophore and aggregation-induced emission (AIE) was designed for sensitive determination of prostate-specific antigen (PSA). The results showed that the sensor had high stability, good selectivity, low detection limit, and a wide linear range.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Shunpei Oikawa, Hiro Minamimoto, Kei Murakoshi
Summary: Improvements in light energy confinement and the improvement of the plasmon excitation lifetime are effective ways to achieve efficient light energy usage on plasmonic nanostructures. Herein, we propose a facile method to improve the quality (Q) factor of an Au nanostructure array using a relatively low annealing temperature method. The present method was demonstrated to be important for obtaining high-quality plasmonic structures.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Spectroscopy
Qin Ouyang, Yongcun Yang, Shujat Ali, Li Wang, Huanhuan Li, Quansheng Chen
Summary: The study developed a rapid, sensitive, and specific aptasensor based on FRET for detecting Staphylococcus aureus in food. Under optimized conditions, there was a significant linear correlation between fluorescence intensity and S. aureus concentration, demonstrating high detection sensitivity and accuracy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Ruidi Shen, Ji Zhang, Wenxiu Huang, Shaoyong Wu, Gongke Li, Seyin Zou, Liansheng Ling
Summary: The study developed a new diagnostic method using specific oligonucleotides to detect CA-125 through PCR and AuNPs-DNA probes, achieving rapid diagnosis of ovarian cancer.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Wanhe Wang, Jianhua Liu, Li-An Wu, Chung-Nga Ko, Xueliang Wang, Chuankai Lin, Jingqi Liu, Liansheng Ling, Jing Wang
Summary: This study presents a synergetic signal amplification system combining CRISPR-Cas12a and nicking enzyme-free strand displacement amplification (SDA) technique for accurate detection of prostate-specific antigen (PSA). The system successfully discriminated blood samples from prostate cancer patients among normal individuals/cancer patients.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Tao Hu, Zeyang Bai, Di Wang, Ying Bai, Xiao Li, Zhonghua Ni
Summary: This study reported a 3D graphene aerogel (GA)/AuNPs/Nafion electrochemical platform for highly sensitive quantification of PSA. By immobilizing aptamers on the modified electrode surface and using electrocatalysts for signal amplification, this electrochemical immunosensor exhibited sensitive and stable responses for PSA detection in the concentration range of 0.05 to 50 ngemL-1.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Sheida Khajir, Zahra Karimzadeh, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Elaheh Rahimpour, Abolghasem Jouyban
Summary: In this study, a RLS technique based on beta-cyclodextrin modified gold nanoparticles was used to determine phenytoin concentration in exhaled breath condensate. The method relies on the formation of a complex between beta-cyclodextrins and phenytoin, resulting in an aggregation-induced Rayleigh light scattering intensity enhancement that is proportional to the phenytoin concentration. The method has a linear relationship with phenytoin concentration in the range of 0.005-0.6 μg/mL and a limit of detection of 0.003 μg/mL.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Yu Jiang, Xifeng Chen, Ninghan Feng, Peng Miao
Summary: This study presents a highly sensitive electrochemical biosensor for PSA detection based on split aptamer and dumbbell hybridization chain reaction, with a detection limit of 0.5 pg mL-1. The method shows great promise in clinical diagnosis with high selectivity, stability, reproducibility, and detection sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Canan Ozyurt, Inci Uludag, Mustafa Kemal Sezginturk
Summary: This study developed a disposable electrochemical aptasensor based on ITO-PET film for sensitive and selective detection of prostate-specific antigen (PSA) in real serum samples. The biosensor exhibited excellent sensitivity, precision, repeatability, and storage stability, making it a potential candidate for clinical applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Mohamad Mahani, Fatemeh Alimohamadi, Masoud Torkzadeh-Mahani, Zahra Hassani, Faeze Khakbaz, Faten Divsar, Mehdi Yoosefian
Summary: In this study, an ultra-sensitive label-free nanobiosensor was developed for the detection of PSA at low concentrations in urine samples. Computational modeling and molecular dynamics simulations were used to investigate the binding mechanism between antibody and PSA protein, while factors affecting the detection were optimized to achieve a detection limit of 0.2 ng mL(-1) and calibration sensitivity of 0143.75 nm (ng mL(-1)).
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Wanhe Wang, Jingqi Liu, Xiaoxia Li, Chuankai Lin, Xueliang Wang, Jianhua Liu, Liansheng Ling, Jing Wang
Summary: CRISPR/Cas12a-based biosensors have been widely studied for nucleic acid detection, but this study demonstrates their use in colorimetric detection of serum PSA using an enzyme-free HCR-powered system. The assay shows sensitive and selective detection capabilities in both visual and quantitative modes, highlighting its potential for protein cancer biomarker detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Siphesihle Robin Nxele, Reitumetse Nkhahle, Tebello Nyokong
Summary: PSA aptasensors were fabricated using novel materials and their detection performance was studied using electrochemical methods, showing potential for clinical applications based on consistent results in spiked serum samples and buffer solutions.
Article
Chemistry, Multidisciplinary
Kui He, Yue Tan, Zhipeng Zhao, Huarui Chen, Jinbin Liu
Summary: The study achieved controllable weak anchoring sites of luminescent gold nanoparticles and demonstrated the importance of N-Au and COO-Au weak anchoring sites in the behavior of AuNPs, opening up new possibilities for advances in the field of nanomedicine.
Review
Chemistry, Multidisciplinary
Xiaoxi Luo, Jinbin Liu
Summary: In the past decade, ultrasmall luminescent metal nanoparticles have made rapid progress in addressing challenges in healthcare due to their excellent properties. Surface engineering strategies of ULMNPs, including enhancing disease targeting abilities and self-assembly for multifunctional structures, have significantly advanced biological applications from bioimaging to theranostics. Further research on ratiometric ULMNPs for improved imaging stability in complex biological environments, along with the exploration of phototoxicity and future perspectives, aim to accelerate their clinical applications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuewei Liu, Rongkang Gao, Chiyun Chen, Xiaobo Li, Chen Yu, Yejia Chen, Hongbin Liang, Min Xiao, Lei Dai, Shifeng Qiu, Xiaoyu Xin, Liang Song, Jinbin Liu, Chengbo Liu, Jiancheng Xiu
Summary: In this study, noninvasive assessment of alpha v beta 3-integrin expression in atherosclerotic lesions of varying degrees of severity was performed using a customed photoacoustic (PA) computed tomography (PACT)/ultrasound (US) system. The results showed that alpha v beta 3-integrin is an effective indicator of plaque instability, and noninvasive PACT/US molecular imaging assessment of alpha v beta 3-integrin holds promise in detecting high-risk plaques.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Kai Zhou, Wei Cai, Yue Tan, Zhipeng Zhao, Jinbin Liu
Summary: By manipulating the siloxane bridge crosslinking states, water-soluble nanoassemblies with disassembly-induced emission enhancement (DIEE) were successfully fabricated. The disassembled nanoassemblies showed more than 6-fold enhancement in emission and improved renal clearance efficiency, opening up new possibilities for designing highly emissive renal-clearable nanostructures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yue Tan, Wei Cai, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: By designing luminescent gold-silver bimetallic nanoparticles that can be rapidly transformed in the hepatic sinusoidal microenvironment, liver sequestration can be avoided, phagocytosis by mononuclear phagocyte system cells can be enhanced, rapid release can be promoted, renal clearance can be improved, and disease targeting can be increased.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Bing Tang, Wenle Xia, Wei Cai, Jinbin Liu
Summary: In this study, luminescent AuNPs with redshifted emission and good biocompatibility were successfully constructed using an amphiphilic block copolymer template. The strategy involved the formation of uniform clusters of NIR-II AuNPs inside the hydrophobic cores of ABC micelles and the generation of rigid NIR-II AuNPs as ABC unimers on the surface, enabling enhanced biological interactions.
Article
Chemistry, Multidisciplinary
Wei Cai, Yue Tan, Kui He, Bing Tang, Jinbin Liu
Summary: A precise control of nanoparticle size in the sub-nanometer regime is crucial for understanding nano-bio interactions and advancing nanomedicine. This study presents a simple Mn2+-guided centrifugation strategy to synthesize large-scale ultrasmall AuNPs with precise size gradient at the sub-nanometer regime. The researchers discovered that [Mn(OH)](+) nanoparticles, particularly Mn-0@[Mn(OH)](+), can selectively interact with larger AuNPs to form aggregates, leading to the efficient synthesis of water-soluble atomically precise Au-25 within a short time. Moreover, the study demonstrates the significant impact of sub-nanometer size differences on non-specific phagocytosis, elimination rate, and nanotoxicology of AuNPs in macrophages.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Zhipeng Zhao, Huarui Chen, Kui He, Jincheng Lin, Wei Cai, Yidan Sun, Jinbin Liu
Summary: This study develops a facile in vivo ligand exchange strategy to achieve renal-clearable activatable luminescent gold nanoparticles (AuNPs), which are independent of biomarkers for sensitive and long-time imaging of early kidney injury.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kui He, Yuan-Fu Ding, Zhipeng Zhao, Ben Liu, Wenyan Nie, Xiaoxi Luo, Hua-Zhong Yu, Jinbin Liu, Ruibing Wang
Summary: This study reports a strategy to achieve liver or kidney-specific delivery by altering the surface chemistry of nanocarriers. The results demonstrate that ultrasmall nanocarriers can effectively deliver drugs to injured kidneys and achieve improved therapeutic outcomes. This organ-specific delivery strategy provides a new approach for improving drug delivery efficiency and personalized treatments.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Wenyan Nie, Kui He, Zhipeng Zhao, Xiaoxi Luo, Jinbin Liu
Summary: We developed a facile in situ strategy to precisely control DNA aptamer valences on the surface of luminescent gold nanoparticles (AuNPs) with emission in the second near-infrared window. We further demonstrated that not only the tumor-targeting efficiencies but also the subcellular transport of AuNPs show precise valence dependence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yue Tan, Di Huang, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: In this study, clearable mercaptosuccinic acid (MSA) coated Au-Ag bimetallic nanoparticles (NPs) were designed to enhance reactive oxygen species (ROS) production. The strong COO-Ag coordination bonds between MSA and Ag atoms on the NPs restricted intrananoparticle motions, leading to enhanced ROS generation. The bimetallic NPs also exhibited pH-responsive self-assembly capability, further boosting ROS production and showing high tumor targeting efficiency and effective cancer cell destruction.
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Zhipeng Zhao, Huarui Chen, Xinglin Chen, Jinbin Liu
Summary: This study demonstrates that renal-clearable nanomedicines show a more sensitive response to injection dose and have improved tumor-targeting efficiency compared to nonrenal-clearable nanoparticles.
Article
Chemistry, Multidisciplinary
Liting Nong, Tingyao Zhou, Huarui Chen, Bing Tang, Jinbin Liu
Summary: The study focused on the application of amphiphilic block copolymers in the encapsulation and transport of inorganic nanomedicines. Three well-controlled gold nanoassemblies with different shapes and loadings were successfully fabricated, showing tailored in-vivo transport behaviors. Specifically, nanoassemblies with spherical shape and more hydrophilic surface exhibited higher tumor-targeting efficiency and long-term tumor imaging.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Physical
Kui He, Jiayi Zhu, Lingshan Gong, Yue Tan, Huarui Chen, Huarun Liang, Baihao Huang, Jinbin Liu
Summary: By utilizing a well-designed CP template, AuNPs were successfully self-assembled into 1D nanostructures as AuNPs@CP with enhanced NIR emission, efficient cellular uptake, lysosome escape, and fast cellular excretion, showing high gene transfection efficiency and minimal healthy organ retention.
Article
Chemistry, Multidisciplinary
Yue Tan, Wei Cai, Caiming Luo, Jiahao Tang, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Jinbin Liu, Ben Zhong Tang
Summary: The rapid transformation of luminescent gold-silver bimetallic nanoparticles in the hepatic sinusoidal microenvironment can help avoid MPS phagocytosis, promote fast release from the liver, prolong blood circulation, enhance renal clearance, and increase disease targeting, turning liver sequestration into a beneficial storage mechanism for nanomedicines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
