Article
Chemistry, Multidisciplinary
Joonyoung Lee, Ki-Yoon Kim, Yongchai Kwon, Dahl-Young Khang
Summary: This study proposes stretchable enzymatic biofuel cells (EBFCs) with high performance for power supply. The buckled gold electrodes increase the electrode surface area and catalyst loading, resulting in improved reaction rates. The evaluated EBFCs achieve a maximum power density of 7.1±0.64μW cm-2.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Min Dong, Zhihong Gao, Yating Zhang, Jiahui Cai, Jian Li, Panpan Xu, Hong Jiang, Jianmin Gu, Jidong Wang
Summary: In this study, a highly efficient enzymatic cascade reaction based on a multiwalled carbon nanotubes-chitosan composite was designed for detecting circulating tumor cells (CTCs). By modifying a glassy carbon electrode (GCE) with the composite, a high electrochemical effective surface area was achieved for loading glucose oxidase (GOD), enabling ultrasensitive detection of CTCs in serum samples. This electrochemical sensor holds great potential for early diagnosis and clinical analysis of cancer.
Article
Chemistry, Multidisciplinary
Shoichi Nishitani, Tiffany Tran, Andrew Puglise, Sounghyun Yang, Markita P. Landry
Summary: This study presents the development of near-infrared fluorescent single-walled carbon nanotube (SWCNT) based nanosensors for glucose imaging. The authors find that the fluorescence modulation of GOx-SWCNT is not associated with the enzymatic activity but rather triggered by the substrate-enzyme binding. Leveraging this unique mechanism, the authors developed catalytically inactive nanosensors that enable glucose imaging in mouse brain slices.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Energy & Fuels
Sufia ul Haque, Abu Nasar, Narcis Duteanu, Inamuddin
Summary: In recent years, biological fuel cells (BFCs) have gained attention as a technology to address energy crises. However, the long-term stability and low power output of BFCs remain challenging. Enzyme-based biofuel cells (EFCs) utilizing nanomaterials, particularly carbon-based nanomaterials, have shown promise in enhancing efficiency and high energy generation.
Article
Chemistry, Multidisciplinary
Jungyeon Ji, Seongjun Kim, Yongjin Chung, Yongchai Kwon
Summary: Polydopamine (PDA) is used as a biocompatible mediator for fabricating glucose oxidase (GOx) based bioanode of enzymatic biofuel cells (EBFCs). Through the autoxidation and polymerization of dopamine monomer, spherical PDA particles are well synthesized, and their chemical and optical characteristics are verified. The durability of the bioanode is improved by introducing polyethyleneimine (PEI) as a catalyst, which effectively suppresses the leaching out of PDA and GO(x) molecules. The suggested new catalyst shows better performance and higher power density in EBFC.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Physical
Ji Hyun Yang, Hyeong Ryeol Kim, Ja Hyun Lee, Joon-Hyung Jin, Hee Uk Lee, Seung Wook Kim
Summary: The study aimed to enhance power output by optimizing electrical communication for GOx on a composite surface and found that immobilized GOx at a concentration of 40:80 mM EDC:NHS exhibited the highest activity with a power density of 2.24 mWcm(-2) under optimal conditions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Multidisciplinary
Isao Shitanda, Kanako Oda, Noya Loew, Hikari Watanabe, Masayuki Itagaki, Seiya Tsujimura, Abdelkader Zebda
Summary: A novel bio-composite ink for screen-printed bioanodes was successfully developed in this study, achieving high sensitivity and maximal power density while simplifying the printing and drop-casting processes.
Article
Chemistry, Analytical
Saikat Banerjee, Gymama Slaughter
Summary: A glucose abiotic biofuel cell was developed using gold nanoparticles ink printed electrodes on bacterial nanocellulose, with a colloidal platinum anode and silver oxide/multiwalled carbon nanotube nanocomposite cathode. The cell exhibited high open circuit voltage, short circuit current density, and maximum power density at different glucose concentrations, showing good performance in serum with glucose.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yang-Yang Hou, Jing Xu, Fu-Ting Wang, Zhong Dong, Xuecai Tan, Ke-Jing Huang, Jia-Qiang Li, Chun-Yang Zuo, Si-Qi Zhang
Summary: A novel self-powered biosensing platform was developed for detecting miRNA, utilizing an EBFC-based biosensor with a matching capacitor. By improving the EBFC performance with catalytic hairpin assembly and hybrid chain reaction, along with using a matching capacitor for signal amplification, the sensitivity was significantly increased.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Natcha Rasitanon, Kornautchaya Veenuttranon, Hnin Thandar Lwin, Kanyawee Kaewpradub, Tonghathai Phairatana, Itthipon Jeerapan
Summary: This study successfully integrated glucose oxidase (GOx) with nanomaterial-modified electrodes using egg white proteins, and demonstrated the potential of this biocompatible interface in bioelectronics, such as glucose sensors and biofuel cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ruma Perveen, Abu Nasar, Inamuddin, Suvardhan Kanchi, Heba Abbas Kashmery
Summary: Enzymatic biofuel cells (EBFCs) are a promising technology for portable energy sources, with electrode materials playing a crucial role in research. A new nanocomposite platform has been developed for immobilizing glucose oxidase (GOD), improving enzyme bioelectrocatalysis for glucose oxidation. The composite shows promising results in enhancing electrode surface area and facilitating electron transfer between enzymes and electrode, making it a potential material for developing improved electrochemical biosensors and biofuel cell anodes.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Materials Science, Multidisciplinary
Kai Cheng, Junlei Wang, Xueqin Wang, Zengkai Wang, Liwei Zhang, Ying Li, Lei Liu
Summary: This study successfully prepared novel films of TiO2 nanotubes based on a silk fibroin substrate, which have sufficient mechanical strength and flexibility, with the nanotube structure remaining unchanged and suitable for further applications.
Article
Chemistry, Physical
Jeonghun Yun, Zongkang Li, Xinwen Miao, Xiaoya Li, Jae Yoon Lee, Wenting Zhao, Seok Woo Lee
Summary: Smart contact lenses require miniaturized power supplies, and integrated batteries offer promising options. Charging them is challenging due to the difficulty of transferring electrical power through miniaturized wired connections or wireless units. Therefore, we developed tear-based batteries for contact lenses that are charged by biofuel during storage.
Article
Biochemistry & Molecular Biology
Gangyong Li, Zongdong Wu, Cuixing Xu, Zongqian Hu
Summary: A novel hybrid catalyst cascade system consisting of organic oxidation catalyst TEMPO and enzyme GOx was reported for electrochemical oxidation of glucose. By combining GOx and TEMPO, efficient 4e(-) electrooxidation of glucose was achieved, leading to enhanced energetic efficiency in biofuel cells. This hybrid enzymatic and organic cascade shows promising potential for glucose oxidation in bioelectronics applications.
BIOELECTROCHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Jing-Wen Xu, Ting-Mei Ma, Mi Zhang, Han Zeng
Summary: A metalloprotein-based electrode was successfully prepared using multi-wall carbon nanotubes with polypyrrole, with hemoglobin entrapment achieved via wet-coating. The direct electron transferring of the Hb-based electrode was found to be efficient, with the redox process for the heme site of Hb in coordination with Ppy being surface-controlled. However, the efficiency of Hb-induced catalysis was limited by the step of substrate diffusion.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)