Article
Chemistry, Analytical
Hamid Aghamohammadi, Seied Ali Hosseini, Sanjana Srikant, Alexander Wong, Mahla Poudineh
Summary: This paper introduces a computational model for the rational design and optimization of immunobead-based assays in microfluidic mixing channels. The model examines various factors affecting the efficiency of analyte capture on the surface of microbeads and is validated experimentally. It can be adapted to a wide range of target molecules and different device designs.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Vahid Nasirimarekani, Fernando Benito-Lopez, Lourdes Basabe-Desmonts
Summary: The technology involves manipulating droplets using a magnetic field through the addition of magnetic particles or using magneto responsive surfaces. The experimental study presented and characterized a tunable superparamagnetic ring which stabilizes and enables physical manipulation of droplets on a surface. This work opens new applications in microfluidics and studies on tunable interfaces between immiscible liquids.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Anil Koklu, Shofarul Wustoni, Valentina-Elena Musteata, David Ohayon, Maximilian Moser, Iain McCulloch, Suzana P. Nunes, Sahika Inal
Summary: Alzheimer's disease is a neurodegenerative disorder with no specific cure, emphasizing the importance of early diagnosis. A common pathological change in AD-affected brains is the accumulation of Aβ protein into plaques, which was detected using a micron-scale OECT in this study.
Article
Engineering, Chemical
Ruishan Han, Jianhua Chen, Fang Zhang, Yanlan Wang, Lei Zhang, Feipeng Lu, Haifu Wang, Enyi Chu
Summary: A novel droplet microfluidic technology was used to fabricate HNS microspheres with NC as adhesive, resulting in improved flowability and bulk density compared to raw HNS. The fabrication process was optimized by adjusting parameters such as HNS concentration, NC concentration, and flow rate, while preserving the chemical and crystalline structures of HNS.
Article
Biochemical Research Methods
Azim Parandakh, Oriol Ymbern, William Jogia, Johan Renault, Andy Ng, David Juncker
Summary: Researchers have developed a novel chip-based ELISA technology that enables rapid and highly sensitive antibody detection. The chip simplifies chip loading and pipetting through autonomous aliquoting functionality, and can accommodate higher surfactant concentrations. The ELISA chip can complete the assay in 1.5 hours and exhibits comparable accuracy and performance to central laboratory ELISA.
Review
Chemistry, Analytical
Kieu The Loan Trinh, Hoang Dang Khoa Do, Nae Yoon Lee
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a demand for accurate and cost-effective diagnostic tests for COVID-19 and other viral infections. Traditional virus screening methods have limitations in terms of equipment, personnel, and analysis time. Microfluidic-based biosensors, integrating microfluidic and biosensor technologies, offer a platform for sample preparation and simultaneous detection with high sensitivity, accuracy, portability, and real-time results. This review presents recent advances in microfluidic-based biosensors for virus detection, categorizing them into immunoassays and molecular assays, and analyzes available commercial sensing tests.
Article
Chemistry, Analytical
Chang Liu, Yu Qie, Weiping Qin, Keda Zhao, Jianqiao Zhu, Lixia Zhao, Minjie Li, Liang-Hong Guo
Summary: Exosomes are nano-scale biofilm-enclosed vesicles involved in intercellular communications and seen as potential biomarkers for liquid biopsy. Traditional exosome detection methods have limited sensitivity and specificity, prompting the need for new analytical approaches. Immunoassay-based technologies for rapid exosome detection have gained significant interest recently, offering new possibilities for early disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yuqian Zhang, Yuguang Liu
Summary: A comprehensive system combining electrochemical impedance spectroscopy and digital microfluidics has been introduced to easily and sensitively evaluate a patient's immune function. The unique droplet manipulation feature of the microfluidic platform allows for dynamic cell capture assay, improving detection signal by 2.4-fold, demonstrating high sensitivity.
Article
Pharmacology & Pharmacy
Ju Hee Kim, Choong Ho Ryu, Chan Hee Chon, Seyeon Kim, Sangno Lee, Ravi Maharjan, Nam Ah Kim, Seong Hoon Jeong
Summary: The finasteride-loaded PLGA microspheres prepared using the IVL-PPF Microsphere (R) micmfluidic device showed in vivo drug release with uniform profiles. PLGA 7502A microspheres exhibited extended release, and the addition of PLA02A further prolonged drug release up to 3 months.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Hao Zhang, Luke Liu, Manuel Pinelo, Yuhong Huang, Weiqing Zhou, Yinhua Wan, Jianquan Luo
Summary: In this study, a novel enzymatic packed bed membrane reactor (EPBMR) was developed by integrating the advantages of both packed bed reactor (PBR) and enzymatic membrane reactor (EMR), enabling efficient and stable bioconversions. The use of microspheres and alkaline cleaning mitigated membrane fouling, and the selection of proper ultrafiltration membranes successfully produced oligodextran with desired properties.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Chemical
Hao Zhang, Luke Liu, Manuel Pinelo, Yuhong Huang, Weiqing Zhou, Yinhua Wan, Jianquan Luo
Summary: A novel enzymatic packed bed membrane reactor (EPBMR) was developed by integrating advantages of packed bed reactor (PBR) and enzymatic membrane reactor (EMR). The use of microspheres enlarged the contact area between enzymes and substrates and reduced membrane fouling. The system exhibited a high sucrose conversion rate after 36 hours of continuous operation.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xingkuan Wang, Yiting Lei, Ke Jiang, Caiping Yan, Jieliang Shen, Weikang Zhao, Chao Xiang, Zhengwei Cai, Yang Song, Lu Chen, Wenguo Cui, Yuling Li
Summary: Microfluidics was used to prepare hyaluronic acid hydrogel microspheres as shells and con-covalently connected the inner core-SS-31 peptide and Wyrgrl peptide co-modified long-circulating liposomes loaded with resveratrol (REV) to the nano-network of microspheres to construct a Mito-Battery that could promote cell energy production and fight inflammation by targeted regulation of MRC functions. The modification of peptide could enhance its cellular uptake and improve the mitochondrial-targeting of Mito-Battery. Furthermore, REV loaded in liposomes could activate SIRT3 protein and synergistically enhance the MRC electron transfer efficiency with SS-31. Mito-Battery effectively delayed the progression of the disease in a rat bone and joint model. Thus, Mito-Battery has great potential in the treatment of degenerative diseases related to MRC dysfunction.
Article
Biochemical Research Methods
Haizhen Sun, Yukun Ren, Ye Tao, Tianyi Jiang, Hongyuan Jiang
Summary: The study introduces a technique called alternating current electrothermal-flow field-effect transistor (ACET-FFET) for in-droplet cell/particle concentration. By tuning the electric field and splitting droplets, cells/particles can be flexibly and efficiently concentrated. This technology demonstrates broad applications in droplet microfluidics.
Article
Chemistry, Multidisciplinary
Josiah Rudge, Madeline Hoyle, Neda Rafat, Alexandra Spitale, Margaret Honan, Aniruddh Sarkar
Summary: An inexpensive method is proposed to generate a sensitive direct electronic readout in bead-based immunoassays without using any intermediate optical instrumentation. The binding of analyte to capture antigen-coated beads or microparticles is converted to probe-directed enzymatically amplified silver metallization on microparticle surfaces. Microparticles can be rapidly characterized via single-bead multifrequency electrical impedance spectra using a simple microfluidic impedance spectrometry system. Coupled with a machine learning algorithm, this enables a simple electronic readout of the silver metallization density on microparticle surfaces and the underlying analyte binding. The method is demonstrated for measuring the antibody response to the viral nucleocapsid protein in convalescent COVID-19 patient serum.
Article
Chemistry, Analytical
Sungu Kim, Aparna Krishnamurthy, Pooja Kasiviswanathan, Baskar Ganapathysubramanian, Robbyn K. Anand
Summary: This study demonstrates the use of droplets and ion concentration polarization to rapidly lyse breast cancer cells and enrich low-abundance intracellular analytes.
ANALYTICAL CHEMISTRY
(2023)
Review
Materials Science, Multidisciplinary
Minhuan Jin, Jinyi Wang, Kaiqian Weng, Tianxing Sun, Daying Guo, Xueyu Wang, Xi'an Chen, Shun Wang
Summary: Fluorinated solid-state electrolytes (FSSEs) have been widely used in all-solid-state lithium batteries (ASSLBs) due to their good compatibility, wide electrochemical windows, and stable chemical stability. However, challenges such as ionic conductivity, chemical stability, and current limitation hinder the practical application of fluorinated solid electrolytes. This review discusses the development history of FSSEs, analyzes recent advances in improving ion conductivity, chemical stability, and current limit through structural design, interface regulation strategies, etc., and prospects the design requirements for future generations of FSSEs, focusing on simple one-step synthesis methods, room temperature ionic conductivity improvement, and optimization of the electrochemical stability window of FSSEs.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Analytical
Guorui Zhang, Di Kang, Zhonghui Zhang, Yuanchang Li, Jingjing Jiang, Qin Tu, Junzheng Du, Jinyi Wang
Summary: The filter paper-syringe (FPS) delivery method is a new type of cell permeation approach that forces cells to pass through filter paper quickly, enhancing cell membrane permeability and enabling the delivery of exogenous substances. This method is simple, easy-to-operate, and fast, with delivery efficiency comparable to liposomal delivery of siRNA.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Junyu Su, Maosen Yuan, Lu Han, Hongxia Deng, Jiahao Chang, Yuting Zhuang, Jinyi Wang, Yue Zhang
Summary: In this study, a defluoridation approach based on ultrathin two-dimensional metal organic framework nanosheets was proposed. The Ce-DCPBA nanosheets exhibited high-capacity adsorption of fluoride in a wide pH range. The exceptional selectivity and adsorption ability of Ce-DCPBA make it a promising material for the selective and efficient removal of fluoride from complex environmental samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Yajuan Deng, Tianbao Li, Qin Tu, Jinyi Wang
Summary: Flexible and wearable hydrogel sensors have attracted significant interest due to their potential applications in human-machine interfaces, human-activity monitoring, and personal healthcare diagnosis. This study presents a healable, adhesive, and conductive hydrogel sensor that incorporates polydopamine decorated carbon nanotubes (PDA-CNTs) and FeCl3 into an acrylamide-co-acrylic acid polymer matrix. The hydrogel sensor exhibited good stretchability and high sensitivity, as well as fast and repeatable self-healing ability. It also demonstrated stable and accurate monitoring of human motions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Tao Wang, Jinyi Wang, Pengjie Wang, Fan Wang, Liping Liu, Haijiao Guo
Summary: In this study, a 3D numerical model and quantitative parameters were established to investigate the liquid flow uniformity in a concave-convex bi-polar plate (CCBP) electrolyzer. The simulated velocity field revealed significant non-uniform flow in the CCBP electrolyzer, which was validated by a flow visualization experiment. The residence time distribution (RTD) analysis using the CFD coupled particle tracing method can be applied as a criterion for electrolyzer structure design, operation optimization, and scale-up.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Multidisciplinary
Jinyi Wang, Ling Zhou, Daying Guo, Xueyu Wang, Guoyong Fang, Xi'an Chen, Shun Wang
Summary: A flower-shaped NiS2-WS2 heterojunction was prepared to improve the reaction kinetics of sulfur in lithium-sulfur batteries. The heterojunction enhanced mass and charge transfer, and acted as an electron receptor and a donor for bidirectional catalytic activity. The results showed excellent discharge performance and cycle stability.
Article
Chemistry, Applied
Bin Yang, Jinyi Wang, Yuheng Qi, Daying Guo, Xueyu Wang, Guoyong Fang, Xi'an Chen, Shun Wang
Summary: A systematic modification of separators using bismuth oxycarbonate nanoflowers decorated conductive carbon is proposed, which effectively addresses the shuttle effect of polysulfides in lithium-sulfur batteries and improves battery performance and cycling stability.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Chemistry, Physical
Chenjie Zhang, Lin Huang, Jinyi Wang, Tianliang Zhou, Rong-Jun Xie
Summary: In this work, a method is proposed to find hosts that produce broadband NIR Cr3+ emission by screening Ce3+-doped phosphor hosts, allowing Ce3+ and Cr3+ to occupy the same crystallographic site. A NIR phosphor Ba3Sc4O9:Cr3+ is obtained with an emission peak at 835 nm and a FWHM of 188 nm, where Ce3+ or Cr3+ is accommodated at the same Sc3+ site. By following this method, two broadband NIR phosphors Li3Sc2(PO4)3:Cr3+ (lambda(em) = 1000 nm, FWHM = 223 nm) and Na3Sc2(PO4)3:Cr3+ (lambda(em) = 895 nm, FWHM = 184 nm) are discovered.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Chen Chen, Jian Zhou, Jincheng Yu, Jia Ju, Ying Zhang, Jinyi Wang, Bowen Fan
Summary: Tin bronze was cladded on bare steel and nickel-plated steel to fabricate bimetallic materials. The interfacial microstructures and infiltrated cracks were investigated. Infiltrated cracks originated from the interface and propagated into the interior of the steel along the grain boundaries. When tin bronze was cladded on nickel-plated steel, a transition layer with BCC-Fe structure was also generated and the infiltrated cracks were eliminated.
JOURNAL OF MATERIALS SCIENCE
(2023)
Correction
Chemistry, Multidisciplinary
Zuzhe Kang, Jingjing Jiang, Qin Tu, Shuaiting Liu, Yue Zhang, Dong-En Wang, Jinyi Wang, Mao-Sen Yuan
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Shaofei Shen, Fangjuan Zhang, Yali Zhang, Yi Li, Yanbing Niu, Long Pang, Jinyi Wang
Summary: A multiconcentration gradient generator was constructed to investigate the effect of different drug concentration gradients on cells. The results showed that chemotherapy drugs inhibited the growth of cancer cells, and hepatoma cells exhibited higher drug resistance. This device provides a simple and reliable platform for studying optimal dosages at the single-cell level and screening chemotherapy regimens.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Engineering, Manufacturing
Yong-Hua Shi, Zi-Shun Wang, Xi-Yin Chen, Yan-Xin Cui, Tao Xu, Jin-Yi Wang
Summary: This paper proposes a two-stage model, called the segmentation-LSTM model, to monitor the penetration state of K-TIG welding in real time. The system extracts 9 weld pool geometric features with a segmentation network and extracts the weld gap using a traditional algorithm. These 10-dimensional features are then input into the LSTM model for penetration state prediction, with a recognition accuracy of 95.2%.
ADVANCES IN MANUFACTURING
(2023)
Article
Chemistry, Analytical
Jingcheng Xiao, Jingjing Jiang, Zexu Zhao, Jiahao Guo, Jinyi Wang
Summary: In this study, a distance-based microfluidic paper-based analytical device (muPAD) modified with carboxyl-containing polystyrene nanoparticles (PS-muPAD) was developed to improve the clarity of the discoloration boundary. The modified device showed improved accuracy in calculating analyte content.
ANALYTICAL METHODS
(2023)
Article
Engineering, Chemical
Anrong Yao, Jinghong Qiu, Yafang Wang, Haoyi Hu, Cuimin Huang, Jingyi Wang, Siyao Tian, Lin Yang, Shaojian Lin, Jianwu Lan
Summary: In this study, MIL-88B loaded montmorillonite (MMT) and cellulose nanocrystals (CNC) were incorporated into gelatin aerogel to create a multifunctional and reinforced bio-aerogel, MMCG aerogel, for the removal of organic pollutants. The MMCG aerogel exhibited highly efficient adsorption capacity and showed improved removal performance for all organic contaminants by triggering the Fenton reaction with the addition of H2O2.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Chemistry, Physical
Dianlin Wang, Jiang He, Zili Xiao, Jingyi Wang
Summary: This article discusses the limitations on molar ratios and concentrations in Isothermal titration calorimetry (ITC) caused by the volumes and concentrations of syringe and sample cell. The study explores the neglected aspect of the molar ratios and concentrations of sodium dodecylsulfate (SDS) and imidazolium-based ILs in self-assembly structure transitions. The variations in macroscopic properties and molecular ratios of surfactants responsible for constructing vesicle structures in different alkyl chain lengths systems are investigated using enthalpy changes and cryogenic Transmission Electron Microscopy (cryo-TEM).
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)