4.8 Article

Low background signal platform for the detection of ATP: When a molecular aptamer beacon meets graphene oxide

期刊

BIOSENSORS & BIOELECTRONICS
卷 29, 期 1, 页码 76-81

出版社

ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.07.069

关键词

Molecular aptamer beacon; Graphene oxide; Fluorescence quenching; ATP

资金

  1. National Basic Research Program of China (973 Program) [2011CB933600, 2006CB933100]
  2. NSFC [20621502, 20921062]
  3. National Natural Science Foundation of China [10874135, 20833006, 20875071, 21005056]
  4. Fundamental Research Funds for the Central Universities [20100141110015]

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A novel molecular aptamer beacon (MAB) was designed by integrating a single-labeled hairpin-shaped aptamer and graphene oxide (GO). The hairpin-shaped aptamer was constructed with anti-ATP aptamer and another five nucleotides added to the 5'-end of the aptamer which are complementary to nucleotides at the 3'-end of the aptamer to form a hairpin-shaped probe. This newly designed MAB which acts as a low background signal platform was used for the ATP detection based on long-range resonance energy transfer (LrRET). In the absence of ATP, the adsorption of the dye-labeled hairpin-shaped aptamer on GO makes the dyes close proximity to GO surface resulting in high efficiency quenching of fluorescence of the dyes. Therefore, the fluorescence of the designed MAB is completely quenched by GO, and the system shows very low background. Conversely, and very importantly, upon the adding of ATP, the quenched fluorescence is recovered significantly, and ATP can be detected in a wide range of 5-2500 mu M with a detection limit of 2 mu M and good selectivity. Moreover, when the GO-based MAB was used in cellular ATP assays, preeminent fluorescence signals were obtained, thus the platform of GO-based MAB could be used to detect ATP in real-world samples. (C) 2011 Elsevier B.V. All rights reserved.

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M. Ablikim, M. N. Achasov, P. Adlarson, M. Albrecht, R. Aliberti, A. Amoroso, M. R. An, Q. An, X. H. Bai, Y. Bai, O. Bakina, R. Baldini Ferroli, I. Balossino, Y. Ban, V. Batozskaya, D. Becker, K. Begzsuren, N. Berger, M. Bertani, D. Bettoni, F. Bianchi, J. Bloms, A. Bortone, I. Boyko, R. A. Briere, A. Brueggemann, H. Cai, X. Cai, A. Calcaterra, G. F. Cao, N. Cao, S. A. Cetin, J. F. Chang, W. L. Chang, G. Chelkov, C. Chen, Chao Chen, G. Chen, H. S. Chen, M. L. Chen, S. J. Chen, S. M. Chen, T. Chen, X. R. Chen, X. T. Chen, Y. B. Chen, Z. J. Chen, W. S. Cheng, S. K. Choi, X. Chu, G. Cibinetto, F. Cossio, J. J. Cui, H. L. Dai, J. P. Dai, A. Dbeyssi, R. E. de Boer, D. Dedovich, Z. Y. Deng, A. Denig, I. Denysenko, M. Destefanis, F. De Mori, Y. Ding, J. Dong, L. Y. Dong, M. Y. Dong, X. Dong, S. X. Du, P. Egorov, Y. L. Fan, J. Fang, S. S. Fang, W. X. Fang, Y. Fang, R. Farinelli, L. Fava, F. Feldbauer, G. Felici, C. Q. Feng, J. H. Feng, K. Fischer, M. Fritsch, C. Fritzsch, C. D. Fu, H. Gao, Y. N. Gao, Yang Gao, S. Garbolino, I. Garzia, P. T. Ge, Z. W. Ge, C. Geng, E. M. Gersabeck, A. Gilman, K. Goetzen, L. Gong, W. X. Gong, W. Gradl, M. Greco, L. M. Gu, M. H. Gu, Y. T. Gu, C. Y. Guan, A. Q. Guo, L. B. Guo, R. P. Guo, Y. P. Guo, A. Guskov, T. T. Han, W. Y. Han, X. Q. Hao, F. A. Harris, K. K. He, K. L. He, F. H. Heinsius, C. H. Heinz, Y. K. Heng, C. Herold, G. Y. Hou, Y. R. Hou, Z. L. Hou, H. M. Hu, J. F. Hu, T. Hu, Y. Hu, G. S. Huang, K. X. Huang, L. Q. Huang, X. T. Huang, Y. P. Huang, Z. Huang, T. Hussain, N. Husken, W. Imoehl, M. Irshad, J. Jackson, S. Jaeger, S. Janchiv, E. Jang, J. H. Jeong, Q. Ji, Q. P. Ji, X. B. Ji, X. L. Ji, Y. Y. Ji, Z. K. Jia, H. B. Jiang, S. S. Jiang, X. S. Jiang, Y. Jiang, J. B. Jiao, Z. Jiao, S. Jin, Y. Jin, M. Q. Jing, T. Johansson, N. Kalantar-Nayestanaki, X. S. Kang, R. Kappert, M. Kavatsyuk, B. C. Ke, I. K. Keshk, A. Khoukaz, R. Kiuchi, R. Kliemt, L. Koch, O. B. Kolcu, B. Kopf, M. Kuemmel, M. Kuessner, A. Kupsc, W. Kuhn, J. J. Lane, J. S. Lange, P. Larin, A. Lavania, L. Lavezzi, T. T. Lei, Z. H. Lei, H. Leithoff, M. Lellmann, T. Lenz, C. Li, C. Li, C. H. Li, Cheng Li, D. M. Li, F. Li, G. Li, H. Li, H. Li, H. B. Li, H. J. Li, H. N. Li, J. Q. Li, J. S. Li, J. W. Li, Ke Li, L. J. Li, L. K. Li, Lei Li, M. H. Li, P. R. Li, S. X. Li, S. Y. Li, T. Li, W. D. Li, W. G. Li, X. H. Li, X. L. Li, Xiaoyu Li, Y. G. Li, Z. X. Li, Z. Y. Li, H. Liang, H. Liang, H. Liang, Y. F. Liang, Y. T. Liang, G. R. Liao, L. Z. Liao, J. Libby, A. Limphirat, C. X. Lin, D. X. Lin, T. Lin, B. J. Liu, C. X. Liu, D. Liu, F. H. Liu, Fang Liu, Feng Liu, G. M. Liu, H. Liu, H. B. Liu, H. M. Liu, Huanhuan Liu, Huihui Liu, J. B. Liu, J. L. Liu, J. Y. Liu, K. Liu, K. Y. Liu, Ke Liu, L. Liu, Lu Liu, M. H. Liu, P. L. Liu, Q. Liu, S. B. Liu, T. Liu, W. K. Liu, W. M. Liu, X. Liu, Y. Liu, Y. B. Liu, Z. A. Liu, Z. Q. Liu, X. C. Lou, F. X. Lu, H. J. Lu, J. G. Lu, X. L. Lu, Y. Lu, Y. P. Lu, Z. H. Lu, C. L. Luo, M. X. Luo, T. Luo, X. L. Luo, X. R. Lyu, Y. F. Lyu, F. C. Ma, H. L. Ma, L. L. Ma, M. M. Ma, Q. M. Ma, R. Q. Ma, R. T. Ma, X. Y. Ma, Y. Ma, F. E. Maas, M. Maggiora, S. Maldaner, S. Malde, Q. A. Malik, A. Mangoni, Y. J. Mao, Z. P. Mao, S. Marcello, Z. X. Meng, J. G. Messchendorp, G. Mezzadri, H. Miao, T. J. Min, R. E. Mitchell, X. H. Mo, N. Yu. Muchnoi, Y. Nefedov, F. Nerling, I. B. Nikolaev, Z. Ning, S. Nisar, Y. Niu, S. L. Olsen, Q. Ouyang, S. Pacetti, X. Pan, Y. Pan, A. Pathak, Y. P. Pei, M. Pelizaeus, H. P. Peng, K. Peters, J. L. Ping, R. G. Ping, S. Plura, S. Pogodin, V. Prasad, F. Z. Qi, H. Qi, H. R. Qi, M. Qi, T. Y. Qi, S. Qian, W. B. Qian, Z. Qian, C. F. Qiao, J. J. Qin, L. Q. Qin, X. P. Qin, X. S. Qin, Z. H. Qin, J. F. Qiu, S. Q. Qu, K. H. Rashid, C. F. Redmer, K. J. Ren, A. Rivetti, V. Rodin, M. Rolo, G. Rong, Ch. Rosner, S. N. Ruan, A. Sarantsev, Y. Schelhaas, C. Schnier, K. Schoenning, M. Scodeggio, K. Y. Shan, Fw. Shan, X. Y. Shan, J. F. Shangguan, L. G. Shao, M. Shao, C. P. Shen, H. F. Shen, X. Y. Shen, B. A. Shi, H. C. Shi, J. Y. Shi, Q. Q. Shi, R. S. Shi, X. Shi, X. D. Shi, J. J. Song, W. M. Song, Y. X. Song, S. Sosio, S. Spataro, F. Stieler, K. X. Su, P. Su, Y. J. Su, G. X. Sun, H. Sun, H. K. Sun, J. F. Sun, L. Sun, S. S. Sun, T. Sun, W. Y. Sun, X. Sun, Y. J. Sun, Y. Z. Sun, Z. T. Sun, Y. H. Tan, Y. X. Tan, C. J. Tang, G. Y. Tang, J. Tang, L. Y. Tao, Q. T. Tao, M. Tat, J. X. Teng, V. Thoren, W. H. Tian, Y. Tian, I. Uman, B. Wang, B. Wang, B. L. Wang, C. W. Wang, D. Y. Wang, F. Wang, H. J. Wang, H. P. Wang, K. Wang, L. L. Wang, M. Wang, M. Z. Wang, Meng Wang, S. Wang, S. Wang, T. Wang, T. J. Wang, W. Wang, W. H. Wang, W. P. Wang, X. Wang, X. F. Wang, X. L. Wang, Y. Wang, Y. D. Wang, Y. F. Wang, Y. H. Wang, Y. Q. Wang, Yaqian Wang, Z. Wang, Z. Y. Wang, Ziyi Wang, D. H. Wei, F. Weidner, S. P. Wen, D. J. White, U. Wiedner, G. Wilkinson, M. Wolke, L. Wollenberg, J. F. Wu, L. H. Wu, L. J. Wu, X. Wu, X. H. Wu, Y. Wu, Y. J. Wu, Z. Wu, L. Xia, T. Xiang, D. Xiao, G. Y. Xiao, H. Xiao, S. Y. Xiao, Y. L. Xiao, Z. J. Xiao, C. Xie, X. H. Xie, Y. Xie, Y. G. Xie, Y. H. Xie, Z. P. Xie, T. Y. Xing, C. F. Xu, C. J. Xu, G. F. Xu, H. Y. Xu, Q. J. Xu, X. P. Xu, Y. C. Xu, Z. P. Xu, F. Yan, L. Yan, W. B. Yan, W. C. Yan, H. J. Yang, H. L. Yang, H. X. Yang, L. Yang, S. L. Yang, Tao Yang, Y. F. Yang, Y. X. Yang, Yifan Yang, M. Ye, M. H. Ye, J. H. Yin, Z. Y. You, B. X. Yu, C. X. Yu, G. Yu, T. Yu, X. D. Yu, C. Z. Yuan, L. Yuan, S. C. Yuan, X. Q. Yuan, Y. Yuan, Z. Y. Yuan, C. X. Yue, A. A. Zafar, F. R. Zeng, X. Zeng, Y. Zeng, Y. H. Zhan, A. Q. Zhang, B. L. Zhang, B. X. Zhang, D. H. Zhang, G. Y. Zhang, H. Zhang, H. H. Zhang, H. H. Zhang, H. Y. Zhang, J. L. Zhang, J. Q. Zhang, J. W. Zhang, J. X. Zhang, J. Y. Zhang, J. Z. Zhang, Jianyu Zhang, Jiawei Zhang, L. M. Zhang, L. Q. Zhang, Lei Zhang, P. Zhang, Q. Y. Zhang, Shuihan Zhang, Shulei Zhang, X. D. Zhang, X. M. Zhang, X. Y. Zhang, X. Y. Zhang, Y. Zhang, Y. T. Zhang, Y. H. Zhang, Yan Zhang, Yao Zhang, Z. H. Zhang, Z. Y. Zhang, Z. Y. Zhang, G. Zhao, J. Zhao, J. Y. Zhao, J. Z. Zhao, Lei Zhao, Ling Zhao, M. G. Zhao, Q. Zhao, S. J. Zhao, Y. B. Zhao, Y. X. Zhao, Z. G. Zhao, A. Zhemchugov, B. Zheng, J. P. Zheng, Y. H. Zheng, B. Zhong, C. Zhong, X. Zhong, H. Zhou, L. P. Zhou, X. Zhou, X. K. Zhou, X. R. Zhou, X. Y. Zhou, Y. Z. Zhou, J. Zhu, K. Zhu, K. J. Zhu, L. X. Zhu, S. H. Zhu, S. Q. Zhu, T. J. Zhu, W. J. Zhu, Y. C. Zhu, Z. A. Zhu, B. S. Zou, J. H. Zou, J. Zu

Summary: The Cabibbo-allowed weak radiative decay A+c -> E+gamma has been searched for in a sample of A+c over bar A- c pairs produced in e+e- annihilations, corresponding to an integrated luminosity of 4.5 fb-1 collected with the BESIII detector at center-of-mass energies between 4.60 and 4.70 GeV. No excess of signal above background is observed, and we set an upper limit on the branching fraction of this decay to be B(A+c -> E+gamma) < 4.4 x 10-4 at a confidence level of 90%, which is in agreement with Standard Model expectations.

PHYSICAL REVIEW D (2023)

Article Astronomy & Astrophysics

Measurement of the B+/B0 production ratio in e+e- collisions at the γ(4S) resonance using B → J/ψ(ll)K decays at Belle

S. Choudhury, S. Sandilya, K. Trabelsi, A. Giri, I. Adachi, H. Aihara, D. M. Asner, H. Atmacan, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, T. Bilka, D. Bodrov, G. Bonvicini, J. Borah, A. Bozek, M. Bracko, P. Branchini, T. E. Browder, A. Budano, M. Campajola, D. Cervenkov, M. -C. Chang, C. Chen, B. G. Cheon, K. Chilikin, H. E. Cho, K. Cho, S. -J. Cho, S. -K. Choi, Y. Choi, D. Cinabro, S. Das, G. De Pietro, F. Di Capua, J. Dingfelder, Z. Dolezal, T. V. Dong, D. Epifanov, D. Ferlewicz, B. G. Fulsom, R. Garg, V. Gaur, N. Gabyshev, P. Goldenzweig, E. Graziani, T. Gu, K. Gudkova, C. Hadjivasiliou, T. Hara, K. Hayasaka, H. Hayashii, M. T. Hedges, D. Herrmann, W. -S. Hou, C. -L. Hsu, K. Inami, N. Ipsita, A. Ishikawa, R. Itoh, M. Iwasaki, W. W. Jacobs, E. -J. Jang, Q. P. Ji, S. Jia, Y. Jin, K. K. Joo, K. H. Kang, T. Kawasaki, C. Kiesling, C. H. Kim, D. Y. Kim, K. -H. Kim, Y. -K. Kim, H. Kindo, K. Kinoshita, P. Kodys, T. Konno, A. Korobov, S. Korpar, E. Kovalenko, P. Krizan, P. Krokovny, M. Kumar, R. Kumar, K. Kumara, Y. -J. Kwon, T. Lam, J. S. Lange, M. Laurenza, S. C. Lee, P. Lewis, J. Li, L. K. Li, Y. B. Li, L. Li Gioi, J. Libby, K. Lieret, D. Liventsev, T. Luo, M. Masuda, T. Matsuda, D. Matvienko, S. K. Maurya, F. Meier, M. Merola, F. Metzner, K. Miyabayashi, R. Mizuk, G. B. Mohanty, I. Nakamura, M. Nakao, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, N. K. Nisar, S. Nishida, S. Ogawa, H. Ono, P. Oskin, P. Pakhlov, G. Pakhlova, S. Pardi, S. -H. Park, A. Passeri, S. Patra, S. Paul, T. K. Pedlar, R. Pestotnik, L. E. Piilonen, T. Podobnik, S. Prell, E. Prencipe, M. T. Prim, N. Rout, G. Russo, Y. Sakai, A. Sangal, L. Santelj, V. Savinov, G. Schnell, J. Schueler, C. Schwanda, A. J. Schwartz, Y. Seino, K. Senyo, M. E. Sevior, M. Shapkin, C. Sharma, C. P. Shen, J. -G. Shiu, J. B. Singh, A. Sokolov, E. Solovieva, M. Staric, Z. S. Stottler, J. F. Strube, M. Sumihama, T. Sumiyoshi, M. Takizawa, K. Tanida, F. Tenchini, M. Uchida, T. Uglov, Y. Unno, S. Uno, P. Urquijo, Y. Ushiroda, Y. Usov, R. van Tonder, G. Varner, K. E. Varvell, A. Vinokurova, A. Vossen, E. Waheed, E. Wang, M. -Z. Wang, X. L. Wang, M. Watanabe, S. Watanuki, E. Won, X. Xu, B. D. Yabsley, S. B. Yang, J. Yelton, J. H. Yin, C. Z. Yuan, Y. Yusa, Y. Zhai, Z. P. Zhang, V. Zhilich, V. Zhukova

Summary: We measure the ratio of branching fractions for gamma(4S) decays to B+/B- and B-0(B) over barB(0) using B+ -> J/psi(ll)K+ and B-0 -> J/psi(ll)K-0 samples. With 711 fb(-1) of data collected at the gamma(4S) resonance using the Belle detector, we find the decay rate ratio of gamma(4S) -> B-0(B) over barB(0) over gamma(4S) -> B-0(B) over barB(0) to be 1.065 +/- 0.012 +/- 0.019 +/- 0.047, which is the most precise measurement to date. The uncertainties are due to statistical, systematic, and isospin symmetry assumption in B -> J/psi(ll)K, respectively.

PHYSICAL REVIEW D (2023)

Article Physics, Particles & Fields

The S- and P-wave fully charmed tetraquark states and their radial excitations

Guo-Liang Yu, Zhen-Yu Li, Zhi-Gang Wang, Lu Jie, Yan Meng

Summary: Inspired by recent progresses in observations of the fully charmed tetraquark states by LHCb, CMS, and ATLAS collaborations, a systematic study is performed on the ground states and first radial excitations of the S- and P-wave cc (c) over bar(c) over bar system. The results from calculations using the relativized quark model show that there are no stable bound states for the fully charmed tetraquark states and their sizes are smaller than 1 fm. The X(6600) structure is suggested to be one of the 0(++)(1S) and 2(++)(1S) states or their mixtures, while X(6900) and X(7200) are proposed to be the corresponding states with different quantum numbers.

EUROPEAN PHYSICAL JOURNAL C (2023)

Article Physics, Nuclear

Systematic analysis of doubly charmed baryons Ξcc and Ωcc

Guo-Liang Yu, Yan Meng, Zhen-Yu Li, Zhi-Gang Wang, Lu Jie

Summary: In this study, we systematically investigated the mass spectra, root mean square (r.m.s.) radii, and radial density distributions of the doubly charmed baryons Xi cc and Omega cc within the framework of relativized quark model. Our results indicate that the lowest state of the doubly charmed baryon is dominated by the rho-mode, as the excited energy of this state is lower than those of lambda-mode and lambda-rho mixing mode. Additionally, using the quark model wave functions, we examined the radial density distributions and constructed Regge trajectories for Xi(cc) and Omega(cc) based on the predicted mass spectra, which showed a good fit between the model predictions and the constructed trajectories.

EUROPEAN PHYSICAL JOURNAL A (2023)

Article Astronomy & Astrophysics

Search for rare decays B+ → Ds(*) + η, Ds (*) + (K)over-bar0, D+η, and D+K0

M. Kumar, V. Bhardwaj, K. Lalwani, I. Adachi, H. Aihara, D. M. Asner, T. Aushev, V. Babu, P. Behera, K. Belous, J. Bennett., M. Bessner., B. Bhuyan., T. Bilka., A. Bobrov, D. Bodrov, G. Bonvicini, J. Borah, A. Bozek, M. Bracko, P. Branchini, T. E. Browder, A. Budano, M. Campajola, D. Cervekov, M. -c. Chang, P. Chang, B. G. Cheon, K. Chilikin, H. E. Cho, K. Cho, S. -j. Cho, S. -k. Choi, Y. Choi, S. Choudhury, D. Cinabro, S. Das, N. Dash, G. De Pietro, R. Dhamija, F. Di Capua, J. Dingfelder, Z. Dolezal, T. V. Dong, D. Dossett, D. Epifanov, D. Ferlewicz, B. G. Fulsom, R. Garg, V. Gaur, A. Garmash, A. Giri, P. Goldenzweig, E. Graziani, T. Gu, Y. Guan, K. Gudkova, C. Hadjivasiliou, T. Hara, K. Hayasaka, H. Hayashii, W. -s. Hou, C. -l. Hsu, T. Iijima, K. Inami, N. Ipsita, A. Ishikawa, R. Itoh, M. Iwasaki, W. W. Jacobs, E. -j. Jang, Q. P. Ji, S. Jia, Y. Jin, K. K. Joo, D. Kalita, K. H. Kang, C. Kiesling, C. H. Kim, D. Y. Kim, K. -h. Kim, Y. -k. Kim, K. Kinoshita, P. Kodys, A. Korobov, S. Korpar, E. Kovalenko, P. Krizan, P. Krokovny, R. Kumar, K. Kumara, Y-j. Kwon, T. Lam, J. S. Lange, M. Laurenza, S. C. Lee, C. H. Li, J. Li, L. K. Li, Y. Li, Y. B. Li, L. Li Gioi, J. Libby, K. Lieret, D. Liventsev, M. Masuda, T. Matsuda, D. Matvienko, S. K. Maurya, F. Meier, M. Merola, F. Metzner, K. Miyabayashi, R. Mizuk, G. B. Mohanty, M. Mrvar, I. Nakamura, M. Nakao, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, N. K. Nisar, S. Nishida, S. Ogawa, H. Ono, P. Oskin, P. Pakhlov, G. Pakhlova, S. Pardi, H. Park, S. -h. Park, A. Passeri, S. Patra, S. Paul, T. K. Pedlar, R. Pestotnik, L. E. Piilonen, T. Podobnik, E. Prencipe, M. T. Prim, M. V. Purohit, N. Rout, G. Russo, S. Sandilya, A. Sangal, L. Santelj, V. Savinov, G. Schnell, J. Schueler, C. Schwanda, Y. Seino, K. Senyo, M. E. Sevior, M. Shapkin, C. Sharma, C. P. Shen, J. -g. Shiu, J. B. Singh, E. Solovieva, M. Staric, Z. S. Stottler, J. F. Strube, M. Sumihama, T. Sumiyoshi, M. Takizawa, U. Tamponi, K. Tanida, F. Tenchini, K. Trabelsi, T. Tsuboyama, M. Uchida, Y. Unno, S. Uno, R. van Tonder, G. Varner, K. E. Varvell, A. Vinokurova, E. Waheed, E. Wang, M. -z. Wang, X. L. Wang, M. Watanabe, S. Watanuki, O. Werbycka, J. Wiechczynski, E. Won, B. D. Yabsley, W. Yan, S. B. Yang, J. Yelton, J. H. Yin, C. Z. Yuan, Y. Yusa, Y. Zhai, Z. P. Zhang, V. Zhilich, V. Zhukova

Summary: This study investigates rare decay modes B+ -> D(s)(+)h(0), B+ -> D-s(*)+h(0), and B+ -> D(+)h(0), where h(0) represents the neutral mesons eta or K-0, using a data sample of (772 +/- 10) x 10(6) B(B)bar events. No evidence for these decays is found, and upper limits at the 90% confidence level are set for the branching fractions of B+ -> D(s)(+)h(0), D(s)(*)(+)h(0), and D(+)h(0) decay modes. Additionally, improved measurements of the color-suppressed decay branching fractions B((B)bar(0) -> D-0 eta) = (26.6 +/- 1.2 +/- 2.1) x 10(-5) and B((B)bar(0) -> D-0(K)bar(0)) = (5.6 +/- 0.5 +/- 0.2) x 10(-5) are reported.

PHYSICAL REVIEW D (2023)

Article Biophysics

An integrated centrifugal microfluidic strategy for point-of-care complete blood counting

Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari

Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Immunity testing against COVID-19 from blood by an IoT-enabled and AI-controlled multiplexed microfluidic platform

Nabil H. Bhuiyan, Joon S. Shim

Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Influence of shear stress on electroactive biofilm characteristics and performance in microbial fuel cells

Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour

Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Cheap and portable paper chip with terrific oxidase-like activity and SERS enhancement performance for SERS-colorimetric bimodal detection of intracellular glutathione

Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li

Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes

Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau

Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.

BIOSENSORS & BIOELECTRONICS (2024)

Review Biophysics

Protease detection in the biosensor era: A review

Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov

Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Controllable self-assembled DNA nanomachine enable homogeneous rapid electrochemical one-pot assay of lung cancer circulating tumor cells

Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin

Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Therapeutic drug monitoring mediated by the cooperative chemical and electromagnetic effects of Ti3C2TX modified with Ag nanocubes

Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang

Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

CRISPR-Cas12a powered hybrid nanoparticle for extracellular vesicle aggregation and in-situ microRNA detection

Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu

Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Facile synthesis of dual-ligand europium-metal organic gels for ratiometric electrochemiluminescence detecting I27L gene

Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li

Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

The use of biological fluids in microfluidic paper-based analytical devices (μPADs): Recent advances, challenges and future perspectives

Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho

Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Development of a peptide microarray-based metal-enhanced fluorescence assay for ultrasensitive detection of multiple matrix metalloproteinase activities by using a gold nanorod-polymer substrate

Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang

Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Plasmonic digital PCR for discriminative detection of SARS-CoV-2 variants

Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon

Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode

Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu

Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Gas-responsive two-dimensional metal-organic framework composites for trace visualization of volatile organic compounds

Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang

Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.

BIOSENSORS & BIOELECTRONICS (2024)