Article
Chemistry, Analytical
Fatemeh Maleki, Mohammad-Reza Rashidi, Habib Razmi, Marjan Ghorbani
Summary: A novel electrochemical immunosensor based on immobilization of monoclonal antibody on PAN/Zein-rGO nanofibers was developed for ultrasensitive determination of IGF-1. The PAN/Zein nanofibers provided flexibility and high specific surface area, while rGO nanoparticles improved detection sensitivity and anti-IGF-1 immobilizing. The proposed method showed good selectivity, stability, reproducibility, and acceptable results in the analysis of IGF-1 in human plasma samples.
Article
Food Science & Technology
Lin Zhu, Xiu-Xiu Dong, Chun-Bin Gao, Zuoqi Gai, Yong-Xin He, Zhen-Jie Qian, Yingju Liu, Hong-Tao Lei, Yuan-Ming Sun, Zhen-Lin Xu
Summary: A highly sensitive and selective electrochemical immunosensor was established for the rapid screening of Rhodamine B in paprika and capsicol. Preparation of Rh B complete antigen, obtaining anti-Rh B monoclonal antibody, electrodeposition of cobalt hydroxide and gold nanoparticles, and optimization of the assembled immunosensor contributed to the successful development of the sensor. The assay showed a linear range for Rh B detection, high sensitivity, and good recovery rate, indicating its potential for practical applications.
Article
Electrochemistry
Andre Olean-Oliveira, Patricia Monteiro Seraphim, Marcos F. S. Teixeira
Summary: This study describes the development of an electrochemical immunoassay for the direct detection of methylated DNA using dissolved oxygen as the redox probe. The immunoassay is based on a redox conducting polymer and gold nanoparticles, which enhance sensor performance. No secondary antibodies or enzymes are needed in the construction of this immunoassay.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Amandeep Kaur, Sanjoli Sharma, Shilpa Rana, Rishika Rohilla, Nirmal Prabhakar
Summary: In this study, an impedimetric immunosensor based on Ag-CuO@PANI nanocomposite was developed for sensitive detection of MUC1. The immunosensor showed excellent analytical performance, reproducibility, and long-term storage stability under refrigeration conditions.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Pedro Carneiro, Joana A. Loureiro, Cristina Delerue-Matos, Simone Morais, Maria do Carmo Pereira
Summary: In this study, a sensitive and specific electrochemical immunosensor was developed for the detection and quantification of alpha-synuclein, a biomarker for Parkinson's disease. The immunosensor is based on voltammetric study and uses antibodies to recognize the analyte. The sensor is nanostructured using a layer-by-layer approach and has shown excellent detection capabilities within a certain concentration range.
Article
Chemistry, Analytical
Mingyang Wang, Zongmei Zheng, Yaru Zhang, Ge Wang, Junchong Liu, Haipeng Yu, Aihua Liu
Summary: In this study, a negative pre-screening strategy was proposed to improve the specificity of selected phage monoclonal antibody clones for VEGF165 biopanning. The developed phage-based EIS immunosensor showed excellent affinity and specificity for VEGF165, and it had a linear range of 0.5-1000 pg/mL with a limit of detection of 0.15 pg/mL. This selective phage-based EIS immunosensor has potential applications in diagnosis and therapy.
ANALYTICA CHIMICA ACTA
(2022)
Article
Nanoscience & Nanotechnology
Kannan Sapna, Joseph Sonia, Yoon- Bo Shim, A. B. Arun, K. Sudhakara Prasad
Summary: This article describes the development of a disposable immunosensor based on gold nanoparticle-modified paper electrodes for rapid and sensitive detection of leptospirosis in clinical samples. The sensor has a wide linear range and a low limit of detection, and demonstrates acceptable precision and stability.
ACS APPLIED NANO MATERIALS
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Oncology
Yuwa Ando, Tomokazu Kawaoka, Masanari Kosaka, Yuki Shirane, Yusuke Johira, Ryoichi Miura, Serami Murakami, Shigeki Yano, Kei Amioka, Kensuke Naruto, Yumi Kosaka, Shinsuke Uchikawa, Kenichiro Kodama, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Wataru Okamoto, Shoichi Takahashi, Michio Imamura, Hiroshi Aikata
Summary: This study aimed to identify the risk factors for early onset of proteinuria in patients with unresectable hepatocellular carcinoma receiving atezolizumab plus bevacizumab therapy. The study found that controlling blood pressure is extremely important for the management of proteinuria in these patients.
Article
Chemistry, Applied
Subhasis Mahari, Akanksha Roberts, Sonu Gandhi
Summary: A novel electrochemical biosensor integrated with gold nanorods was used to explore the interaction between antibodies and Salmonella in this study, leading to the development of a method to detect Salmonella in meat and milk samples. The method has a long shelf life, good repeatability, and reproducibility, making it a potential alternative to conventional analytical approaches.
Article
Chemistry, Analytical
Ece Eksin, Hilal Torul, Ece Yarali, Ugur Tamer, Pagona Papakonstantinou, Arzum Erdem
Summary: In this study, a paper-based electrode assemble was developed for detecting miRNA 155 via electrochemical impedance spectroscopy. The system utilized gold nanoparticles modified electrodes and showed different detection limits in different media, while also demonstrating selectivity against non-complementary and mismatch miRNA sequences under various conditions. The impedimetric biosensor's analytical performance and selectivity were also evaluated in fetal bovine serum.
Article
Biotechnology & Applied Microbiology
Jingru Liang, Hang Dong, Fei Xu, Baowei Li, Haimei Li, Limei Chen, Mei Li, Yingchu Liu, Guosheng Jiang, Jinhua Dong
Summary: In this study, a monoclonal antibody named ESC9 was developed, and an immunosensor called ESC9 Quenchbody (Q-body) was generated for rapid and sensitive detection of estradiol. The ESC9 Q-body showed potential for clinical applications due to its excellent detection speed and sensitivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Electrochemistry
Edson Silvio Batista Rodrigues, Giovanna Nascimento de Mello e Silva, Isaac Yves Lopes de Macedo, Wallans Torres Pio dos Santos, Guilherme Rocha Lino de Souza, Gabriel Henrique Santos, Isabela Jube Wastowski, Hatice Ceren Ates, Can Dincer, Eric de Souza Gil
Summary: An impedimetric immunosensor was developed for the detection of RTX from invasive and non-invasive samples. The immunosensor showed high precision and accuracy for on-site RTX detection in blood serum and urine samples. This affordable and label-free electrochemical immunosensor could be used for therapeutic drug monitoring, quality control, and stability monitoring of different drugs.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Oncology
Toshihiko Doi, Yasutoshi Kuboki, Yoichi Naito, Masahiro Ishida, Tetsuya Tanaka, Yoshito Takeuchi
Summary: This study assessed the use of Xentuzumab in Japanese patients with solid tumors and found that it was well tolerated and showed evidence of anti-tumor activity at the appropriate biological dose.
Article
Chemistry, Analytical
Cem Erkmen, Gozde Aydogdu Tig, Bengi Uslu
Summary: In this study, an aptamer-based electrochemical impedance spectroscopy method was developed for the determination of leptin. The aptasensor showed high sensitivity and stability, making it a promising platform for the detection of leptin in human serum and plasma samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Samira Sabouri, Hossein Niknahad, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Asma Najibi, Heresh Rezaei, Alireza Ghiasvand, Parinaz Ahmadi, Ahmad Nikoozadeh, Forouzan Khodaei, Narges Abdoli, Negar Azarpira, Reza Heidari
Summary: Cholestasis is a clinical complication that affects the liver, but other organs, including the lungs, can also be impacted. Cholestasis-induced lung injury can lead to severe complications such as respiratory distress, pulmonary infections, and tissue fibrosis. This study investigated the role of carnosine in protecting against cholestasis-induced lung injury. It was found that carnosine significantly reduced oxidative stress, inflammation, tissue fibrosis, and histopathological changes in the lungs of cholestatic animals.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Mohamed Adel Ahmed, Alireza Ghiasvand, Joselito P. P. Quirino
Summary: Silica nanospheres (SNS) were grown on the inner walls of silica capillaries through a dynamic in situ nucleation process, resulting in highly porous and large accessible surface area substrate. The SNS were functionalized with various groups to develop robust and efficient chromatographic stationary phases, which were compared to conventional capillaries in terms of separation performance. The effects of different solvents, additives, and functional groups on the SNS were studied.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kolsoum Dalvand, Alireza Ghiasvand, Sepideh Keshan-Balavandy, Feng Li, Michael Breadmore
Summary: This article describes a rapid, simple, and sensitive 3D printed microfluidic device integrated with smartphone-based on-chip detection for POCT quantification of urinary uric acid. The device includes two circular inputs connected to microliter-scale chambers, separated by an integrated porous membrane. Under optimal conditions, the device showed a linear calibration curve in the concentration range of 30-600 mg L-1, with a limit of detection of 10.5 mg L-1. The device was successfully used for the recovery and quantification of uric acid in urine.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2023)
Correction
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Samira Sabouri, Hossein Niknahad, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Asma Najibi, Heresh Rezaei, Alireza Ghiasvand, Parinaz Ahmadi, Ahmad Nikoozadeh, Forouzan Khodaei, Narges Abdoli, Negar Azarpira, Reza Heidari
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Chemistry, Analytical
Liang Chen, Alireza Ghiasvand, Brett Paull
Summary: Affordable and accessible diagnostic tools in resource-limited settings are urgently needed to improve global public health. Paper-and thread-based microfluidics have gained significant attention in developing diagnostic devices due to their low-cost, accessibility, simplicity, and portability. This review focuses on fluid transport mechanisms, detection techniques, and applications in microfluidic thread-based analytical devices (mu TADs), discussing challenges and perspectives for further advances and improvements.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Mohamed Hemida, Alireza Ghiasvand, Mirek Macka, Vipul Gupta, Paul R. Haddad, Brett Paull
Summary: Liquid chromatography is a widely used analytical technique in separation science and chemical analysis, and there has been an increasing interest in miniaturizing this technique in recent years. This has been made possible by the development of new miniature and portable detection technologies, allowing for on-site and portable analyses. Significant advancements have been made in the miniaturization of liquid chromatography with photometric, electrochemical, and mass spectrometric detection, leading to the development of field-deployable and portable instruments for various applications. This review provides an overview of recent developments in the miniaturization of detection systems for portable liquid chromatographic systems, along with critical comments and expected future trends.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Sahar Chegeni, Kolsoum Nouriasl, Alireza Ghiasvand
Summary: A new adsorbent based on covalent organic frameworks (COFs) was synthesized and used for the needle trap device (NTD) microextraction. The synthesized adsorbent was characterized using various techniques. The designed microextraction system coupled with GC-FID was used for the analysis of PAHs in contaminated soil samples. RSM with BBD was utilized to optimize the extraction process variables. Under optimal conditions, the method showed good linearity, low detection limit, and acceptable RSD values.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Minoo Barzkar, Alireza Ghiasvand, Mehdi Safdarian
Summary: A new Pb (II) magnetic ion-imprinted polymer (Pb-MIIP) was developed for selective extraction of Pb (II) from water. The MIIP nanostructures were synthesized using iron oxide nanoparticles coated with itaconic acid as a magnetic core, with additional components including a functional monomer, a cross-linker, and an initiator. The synthesis process was confirmed through instrumental and microscopic methods. The Pb (II)-MIIP method exhibited a detection limit of 0.21 μg/L, high recovery (>90%), and low relative standard deviation (<4.9%). The synthesized MIIP showed reusability and successful application in extracting Pb (II) from tap water samples.
Article
Pharmacology & Pharmacy
Mohammad mehdi Ommati, Hossein Niknahad, Asma Najibi, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Parinaz Ahmadi, Alireza Ghiasvand, Maral Javadi, Jamal Yazdani, Samira Sabouri, Heresh Rezaei, Negar Azarpira, Reza Heidari
Summary: Cholestasis-induced lung injury is a severe complication that could lead to tissue fibrosis and respiratory distress. This study found that the level of inflammatory cells, pro-inflammatory cytokines, and IgG in the bronchoalveolar lavage fluid (BALF) of bile duct-ligated mice reached their maximum level on day 28 after surgery. AGM significantly ameliorated cholestasis-induced lung injury.
Article
Biochemical Research Methods
Samira Koonani, Alireza Ghiasvand
Summary: Vacuum-assisted headspace extraction (VA-HSE) is an efficient method for extracting volatile and semi-volatile species. This research focused on modeling VA-HSE of solid samples by considering the impact of reduced pressure on the movement of analyte molecules. The proposed model divided the sampling space into different areas and included a comprehensive equation. The results showed that vacuum increased the volatility of analytes in solid samples and facilitated the diffusion of analyte molecules into the cavities within the solid material. The experimental data validated the reliability and practical relevance of the model.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Kolsoum Nouriasl, Alireza Ghiasvand
Summary: A Cu-MOF/COF hybrid material was synthesized and used for the headspace solid-phase microextraction (HS-SPME) of PAHs in soil samples. The optimized method showed low detection limits and good linearity, demonstrating the effectiveness and reliability of the Cu-MOF/COF hybrid sorbent for sampling ultratrace PAHs in solid samples with complex matrices.
Review
Computer Science, Interdisciplinary Applications
Melika Tasan, Zahrasadat Ghorbaninasab, Saeid Haji-Aghajany, Alireza Ghiasvand
Summary: This study explores the utilization of the Long Short-Term Memory (LSTM) method and GNSS observations for time series prediction of land subsidence. The results demonstrate the crucial role of wet tropospheric data in improving prediction accuracy.
EARTH SCIENCE INFORMATICS
(2023)
Article
Chemistry, Analytical
Samira Koonani, Alireza Ghiasvand
Summary: This study developed a novel adsorbent, Zn-MOF/COF, by combining Zn-based MOF and melamine-based COF. The resulting Zn-MOF/COF sorbent exhibited lower cost and higher extraction efficiency compared to commercial and homemade adsorbents. It was successfully employed for the extraction and enrichment of PAHs in contaminated soil samples.
Review
Chemistry, Analytical
Vahid Jalili, Abdullah Barkhordari, Brett Paull, Alireza Ghiasvand
Summary: PFAS are a group of fluorocarbon compounds with wide-ranging applications, but their persistence and toxic properties make them a concern in the environment. Their strong C-F bonds make it difficult for chemical or biological mechanisms to break them down. Therefore, sensitive and selective analytical methods are needed to detect and trace PFAS in biological and environmental matrices.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Amin Hamdi, Kolsoum Dalvand, Alireza Ghiasvand, Nahid Heidari
Summary: The quality of edible oils can be affected by autoxidation, which alters their flavor and nutritional quality through the production of toxic aldehydes. In this study, a novel AMNS/PPy nanocomposite sorbent was synthesized and used for the analysis of aldehydes in edible oils. The prepared fiber showed excellent repeatability and reproducibility, and was successfully applied for the analysis of aldehydes in commercial edible oil samples.
ACTA CHIMICA SLOVENICA
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
