Article
Chemistry, Multidisciplinary
Maurice Retout, Bryan Gosselin, Amina Adrovic, Pascale Blond, Ivan Jabin, Gilles Bruylants
Summary: In this study, a thin and robust coating based on calixarene-diazonium salts was developed to maintain the anisotropic structure of silver nanoplates, resulting in increased lifetime and stability. This coated silver nanoplates were then used for the detection of rabbit immunoglobulin G and Anti-SARS-CoV-2 IgG, achieving a low limit of detection and successful detection in human plasma. Additionally, the wide range of colors provided by the silver nanoplates allowed for the design of a multicolor multiplex assay for simultaneous detection of multiple analytes.
Review
Chemistry, Multidisciplinary
Xiaoyi Ma, Xiaoqiang Li, Gangyin Luo, Jin Jiao
Summary: This review highlights the importance of DNA-modified gold nanoparticles (DNA-AuNPs) in biomedical applications and their potential uses in various fields. By summarizing the methods for immobilizing DNA strands on the surface of AuNPs and discussing representative studies, the advantages and future challenges of DNA-AuNPs are revealed.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zheng Wei Wong, Siu Yee New
Summary: A fluorescence biosensor based on hybridisation chain reaction amplification coupled with silver nanoclusters has been developed for nucleic acid detection, providing a reliable and low risk method for detecting target DNA.
Article
Chemistry, Analytical
Jana Blaskovicova, Jan Labuda
Summary: Triclosan (TCS) is a widely used broad-spectrum antimicrobial agent in personal care, healthcare, and clinical practice. It has been found to reduce DNA methylation and cause chromosomal aberrations, DNA damage, and strand breaks. The degradation products of TCS also contribute to DNA damage. Silver nanoparticles (AgNPs) have similar antimicrobial properties to TCS and are often used together in oral care products. This study investigates the interaction between AgNPs and DNA, and it is found that AgNPs can protect DNA against TCS-induced damage.
Article
Chemistry, Analytical
Hemeiling Cai, Jing Sun, Zhichang Ma, Junwei Di
Summary: An enhanced charge transfer between BiVO4 and Au nanoparticles was utilized to develop a turn-on photoelectrochemical biosensor for sensitive detection of target DNA. The biosensor showed a linear range from 1 aM to 10 pM with a detection limit of 0.2 aM, making it a promising platform for ultrasensitive DNA detection.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Dedi Futra, Ling Ling Tan, Su Yin Lee, Benchaporn Lertanantawong, Lee Yook Heng
Summary: An ultrasensitive electrochemical DNA biosensor was developed for rapid detection of Vibrio cholerae DNA in environmental samples. The biosensor utilized silica nanospheres functionalized with 3-aminopropyltriethoxysilane and gold nanoparticles for effective immobilization of the capture probe and acceleration of electron transfer. The targeted DNA sequence of V. cholerae was detected using a sandwich hybridization strategy with a pair of DNA probes and evaluated by differential pulse voltammetry.
Article
Chemistry, Medicinal
Adrian Leon-Valencia, Sarah Briceno, Carlos Reinoso, Karla Vizuete, Alexis Debut, Manuel Caetano, Gema Gonzalez
Summary: The photochemical reduction method was used to optimize the deposition of silver nanoparticles on the diatom surface for DNA biosensing. The nanocomposites were characterized using various techniques and a significant enhancement in fluorescence response was observed at 440 nm excitation wavelength. This work demonstrates a low-cost and green alternative fabrication method for fluorescent biosensors by depositing plasmonic nanoparticles on diatoms.
Article
Polymer Science
Li Ding, Zi-Yuan Wang, Ze-Fan Yao, Nai-Fu Liu, Xin-Yi Wang, Yang-Yang Zhou, Longfei Luo, Zhihao Shen, Jie-Yu Wang, Jian Pei
Summary: The study focused on unraveling the energy landscape of conjugated polymers during aggregation and investigating the energetic and structural information of the thermodynamically and kinetically stable aggregates. Through rational molecular design and thermodynamic control, stable aggregates of NDI-based polymers were obtained. The analysis of energetic and structural information provided insights into the relations among the structure, morphology, and properties of conjugated polymers at the molecular level.
Article
Chemistry, Analytical
Like Li, Ya-nan Zhang, Wanlu Zheng, Xuegang Li, Yong Zhao
Summary: This study proposes an optical fiber SPR biosensor based on a sandwich model with gold nanoparticles amplification for high sensitivity DNA hybridization detection. The experimental results show a log-linear response in the DNA concentration range of 1 pM-10 nM with high sensitivity and detection limit.
Article
Biophysics
Skomantas Serapinas, Justina Gineityte, Marius Butkevicius, Rapolas Danilevicius, Marius Dagys, Dalius Ratautas
Summary: This paper presents a new bioelectronic device for the detection of nuclease activity in various fluids. The developed sensor enables rapid and sensitive determination of DNase activity, with high accuracy and reproducibility demonstrated in real human saliva samples. The technology has the potential to improve nuclease quality control processes in the pharmaceutical/biotechnology industry and provide new insights into the importance of nucleases for medical applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Katarina Nemcekova, Veronika Svitkova, Jozef Sochr, Pavol Gemeiner, Jan Labuda
Summary: The ability of silver nanoparticles to be used as drug nanocarriers in the treatment of diseases has been investigated. In this study, gallic acid-coated silver nanoparticles were synthesized and characterized using spectroscopic and electrochemical methods. The nanoparticles showed regulated dissolution, aggregation, and generation of oxygen radicals. Electrochemical sensors were found to be effective in monitoring these processes. The nanoparticles also exhibited stability and electrostatic interaction with DNA. Finally, the drug release of doxorubicin-loaded silver nanoparticles was studied. The results showed potential for the use of electrochemical sensing in monitoring drug delivery systems in cancer therapy.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Omair Adil, Seth B. Eddington, Keith T. Gagnon, Mohtashim H. Shamsi
Summary: Overgrowth of short tandem repeat sequences in genes can cause neurodegenerative disorders. These repeat sequences are ideal targets for label-free electrochemical detection, but their secondary structures and sporadic repeats can complicate detection. By analyzing different nucleic acid microprobe backbones, the study found that the lock-nucleic acid (LNA) microprobe can specifically detect tandem repeats and perform better with the presence of Mg2+. The LNA-based platform shows potential for the development of a reliable biosensor for genetic neurodegenerative disorders.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Esmaeel Alipour, Sheida Norouzi, Shokoufeh Moradi
Summary: An electrochemical DNA biosensor using quercetin as an electroactive indicator was developed for specific target DNA detection, achieving a detection limit of 83 pM with a relative standard deviation of 4.6%. The biosensor was successfully applied for the detection of short sequences of hepatitis C virus and showed selective response to the target DNA.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Physical
Debkumar Bera, Mousumi Baruah, Asish K. Dehury, Animesh Samanta, Yatendra S. Chaudhary, Nirmal Goswami
Summary: Nanoscale assembly of ultrasmall metal nanoclusters using molecular forces has been shown to be a powerful strategy to manipulate their properties in various dimensions. In this study, we demonstrate the formation of kinetically trapped assemblies with enhanced photoluminescence and extended this principle to other materials. We also show a thermal energy driven process to isolate these assemblies, which exhibit thermodynamic stability and unique properties. Our strategy may have broader applications in creating different MNC-based assemblies with unforeseen arrangements and properties.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Chen Chen, Jin-Xin Ma, Hui Wang, Hui-Qiao Liu, Shu-Wei Ren, Jun-Tao Cao, Yan-Ming Liu
Summary: A spatially resolved ratiometric electrochemiluminescence immunosensor was developed for myoglobin detection, using resonance energy transfer for signal amplification. The sensor exhibited high selectivity, sensitivity, and accuracy, making it a promising tool for biomarker analysis.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Spectroscopy
Hasan Motaghi, Masoud Ayatollahi Mehrgardi
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Chemistry, Analytical
Seyyed Mehdi Khoshfetrat, Hosein Khoshsafar, Abbas Afkhami, Masoud A. Mehrgardi, Hasan Bagheri
ANALYTICAL CHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
Samaneh Kabirian-Dehkordi, Mounira Chalabi-Dchar, Hichem C. Mertani, Dominique Le Guellec, Bernard Verrier, Jean-Jacques Diaz, Masoud A. Mehrgardi, Philippe Bouvet
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Electrochemistry
Maryam Shokouhi, Masoud A. Mehrgardi
Article
Pharmacology & Pharmacy
Roghayeh Kamran Samani, Mohamad Bagher Tavakoli, Fatemeh Maghsoudinia, Hasan Motaghi, Seyed Hossein Hejazi, Masoud A. Mehrgardi
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Materials Science, Multidisciplinary
Mahdi Asgari, Hossein Khanahmad, Hasan Motaghi, Amin Farzadniya, Masoud A. Mehrgardi, Parvaneh Shokrani
Summary: The study presents a multifunctional aptamer nanoprobe for fluorescence and magnetic resonance targeted imaging of human ovarian cancer cells, demonstrating high cytotoxic effects and tumor-targeting capabilities, making it a potential contrast agent for MRI and fluorescent probe for microscopic imaging.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Pharmacology & Pharmacy
Fatemeh Maghsoudinia, Mohamad Bagher Tavakoli, Roghayeh Kamran Samani, Hasan Motaghi, Seyed Hossein Hejazi, Masoud A. Mehrgardi
Summary: Dual-targeted gadolinium-carbon dots functionalized with Bevacizumab and/or folic acid showed high relaxivities and strong fluorescence, with low toxicity. Functionalization significantly improved the uptake by cancer cells and enhanced diagnostic accuracy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Abolghasem Abbasi Kajani, Masoud Ayatollahi Mehrgardi
Summary: This study developed a novel theranostic nanoplatform for simultaneous fluorescent monitoring and stimuli-triggered drug delivery. The biocompatible and mono-disperse nanocarriers showed high drug loading capacity and were suitable for real-time monitoring of drug delivery.
Article
Biochemistry & Molecular Biology
Fatemeh Shafiei, Reyhaneh Sadat Saberi, Masoud A. Mehrgardi
Summary: The study developed a graphene-based aptasensor for sensitive detection of human breast cancer cells, showing high selectivity and sensitivity. The aptamer played a key role in improving the properties of the composite for cell capture.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Fatemeh Maghsoudinia, Mohamad Bagher Tavakoli, Roghayeh Kamran Samani, Seyed Hossein Hejazi, Tayebe Sobhani, Fatemeh Mehradnia, Masoud A. Mehrgardi
Summary: Dual-modal molecular imaging using folic acid-functionalized gadolinium-loaded nanodroplets shows great potential for early cancer diagnosis, with high biocompatibility and strong imaging capabilities observed both in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Masoud A. Mehrgardi, Mohammad Mofidfar, Richard N. Zare
Summary: Water has the ability to produce hydrogen peroxide when sprayed to form microdroplets, and gas-surface interactions increase the concentration of hydrogen peroxide.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Roghayeh Kamran Samani, Fatemeh Maghsoudinia, Fatemeh Mehradnia, Seyed Hossein Hejazi, Mohsen Saeb, Tayebe Sobhani, Zohreh Farahbakhsh, Masoud A. Mehrgardi, Mohamad Bagher Tavakoli
Summary: This study synthesized folic acid-functionalized methotrexate-loaded nanodroplets and found their potential in ultrasound-guided chemoradiotherapy of breast cancer. In vitro and in vivo experiments confirmed the high biocompatibility and low toxicity of the nanodroplets.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Roghayeh Kamran Samani, Fatemeh Maghsoudinia, Mahdi Asgari, Maryam Atarod, Masoud A. Mehrgardi, Mohamad Bagher Tavakoli
Summary: In this study, folic acid-targeted superparamagnetic iron oxide nanoparticles were successfully synthesized for dual-modal ultrasound and magnetic resonance imaging-guided drug delivery. The nanodroplets showed high biocompatibility and enhanced cellular uptake, and ultrasound exposure further enhanced drug release and cell cytotoxicity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Abolghasem Abbasi Kajani, Laleh Rafiee, Mohamadmahdi Samandari, Masoud Ayatollahi Mehrgardi, Bahare Zarrin, Shaghayegh Haghjooy Javanmard
Summary: A facile and sensitive method for the detection and isolation of circulating tumor cells (CTCs) was developed using aptamer-targeted magnetic nanoparticles (Apt-MNPs) in conjugation with a microfluidic device. The method showed high capture efficiency and potential for the detection and capture of CTCs.
Article
Chemistry, Multidisciplinary
Mandi Asgari, Hasan Motaghi, Hossein Khanahmad, Masoud A. Mehrgardi, Amin Farzadniya, Parvaneh Shokrani
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)