Article
Chemistry, Analytical
Ben Jabrallah Taha, Chaabani Amal, Belhadj Tahar Noureddine
Summary: The electrochemical behavior of sulfaguanidine was studied in PBS buffer solutions. Cyclic voltammograms revealed that (1) Sg displayed a defined irreversible oxidation peak; (2) the signal-to-background current ratio was three times higher on COOH-MWCNT coated GCE than bare GCE; (3) modifying GCE with COOH-MWCNT significantly improved the electrochemical response (2.7-fold increase). The oxidation of Sg was found to follow a diffusion-controlled mechanism. A linear calibration curve was obtained for the oxidation of Sg in the concentration range of 10-70 μM. The COOH-MWCNT coated GCE was successfully used for the determination of Sg in real samples.
Article
Chemistry, Multidisciplinary
Sheriff A. Balogun, Omolola E. Fayemi
Summary: The supercapacitive properties of synthesized nickel phthalocyanine multiwalled carbon nanotubes nanocomposite on a glassy carbon electrode were investigated in four different electrolytes. The successful synthesis of the nanocomposite was confirmed using various techniques. The modified electrode showed excellent supercapacitive behaviors, with the highest specific capacitance achieved in 0.1 M PBS (pH 7). The GCE-NiPcMWCNTs electrode demonstrated the fastest electron transport capability and the highest power density in H2SO4 electrolyte.
Article
Chemistry, Multidisciplinary
Quanfeng He, Lanping Zeng, Lianhuan Han, Matthew M. Sartin, Juan Peng, Jian-Feng Li, Alexander Oleinick, Irina Svir, Christian Amatore, Zhong-Qun Tian, Dongping Zhan
Summary: Studies have shown that the adsorption of atomic hydrogen on single layer graphene can effectively store hydrogen and is suitable for solutions involving hydrogen fuel cells for vehicles. Utilizing a Pt-electrocatalyzed spillover-surface diffusion-chemisorption mechanism, hydrogenation of graphene can be carried out under mild conditions, demonstrating high storage capacity and stability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Emmanuel Picheau, Anthony Impellizzeri, Dmitry Rybkovskiy, Maxime Bayle, Jean-Yves Mevellec, Ferdinand Hof, Hassan Saadaoui, Laure Noe, Abraao Cefas Torres Dias, Jean-Luc Duvail, Marc Monthioux, Bernard Humbert, Pascal Puech, Christopher P. Ewels, Alain Penicaue
Summary: Above a critical diameter, carbon nanotubes collapse into flattened forms, leading to unique Raman spectra changes. The presence of edge cavities and curvature changes near the edges activate a D band despite overall continuity in the structure. The differing perspectives of chemists and physicists on defects in carbon structures may lead to confusion for researchers in nanotechnologies.
Article
Chemistry, Multidisciplinary
Aikaterini Gkaravela, Ioanna Vareli, Dimitrios G. Bekas, Nektaria-Marianthi Barkoula, Alkiviadis S. Paipetis
Summary: This study proposes that Electrochemical Impedance Spectroscopy (EIS) can be used to monitor and characterize the dispersion state of carbon nanotubes (CNTs) during sonication. By monitoring the Impedance |Z|, the study confirms that the change in |Z| can indicate the formation or destruction of conductive paths during sonication, providing valuable information for creating an optimum dispersion protocol for conductive CNT suspensions.
Article
Chemistry, Analytical
Waralee Ruankham, Tanawut Tantimongcolwat, Kamonrat Phopin, Joan Bausells, Marie Hangouet, Marie Martin, Nadia Zine, Abdelhamid Errachid
Summary: Pesticide contamination in food and its persistence in the environment is a major global issue. A label-free impedimetric aptamer-based biosensor was developed for the determination of chlorpyrifos (CPS) residues. The biosensor showed good selectivity and reproducibility for CPS.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Ji-Hoon Han, Sungu Hwang, Joon Hyub Kim
Summary: In this study, the improvement in surface inertness of carbon-nanotube (CNT) surfaces treated with oxygen plasma was analyzed using electrochemical impedance spectroscopy (EIS). CNTs are highly desirable nanomaterials due to their exceptional properties, but the chemical inactivity of CNT surfaces limits their application in bioanalytical field. Consequently, we present a comprehensive analysis of the electrochemical properties of CNTs treated under various plasma conditions.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Adina Stegarescu, Humberto Cabrera, Hanna Budasheva, Maria-Loredana Soran, Ildiko Lung, Francesca Limosani, Dorota Korte, Matteo Amati, Gheorghe Borodi, Irina Kacso, Ocsana Opris, Monica Dan, Stefano Bellucci
Summary: This study demonstrates the adsorption and photodegradation capabilities of modified multi-walled carbon nanotubes (MWCNTs) using tartrazine as a model pollutant. The optimal adsorption conditions are pH 4 for MWCNT-COOH/Fe3O4 and pH 3 for MWCNT-COOH/Fe3O4/NiO. The predominant degradation process is through photodegradation rather than adsorption.
Article
Chemistry, Physical
Ruth Sang Jones, Beomseok Kim, Jin-Woo Han, M. Meyyappan
Summary: Carboxylated single-walled carbon nanotubes have been studied for gas and vapor sensing, with controlled pH values enabling an array of sensors that can give orthogonal responses to target gases and vapors. The gas detection mechanism for these sensors under prevailing humidity is via protonation or deprotonation of the carboxylate groups induced by pH changes. A computational model has been developed to control pH and test various target gases, confirming its utility in decision-making on sensor design and developing multiple sensor arrays for constructing an electronic nose with machine learning.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Mehrnaz Ghanavati, Fariba Tadayon, Asal Basiryanmahabadi, Niloufar Torabi Fard, Erfan Smiley
Summary: This study developed an electrochemical sensor for simultaneous detection of NAP and SUM using a modified carbon electrode surface. The modified electrode showed improved electro-oxidation peaks currents and easier oxidation of the target drugs. The method was proven to be suitable for simultaneous determination of NAP and SUM in biological fluids and pharmaceutical compounds.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Physical
Muhammad Akram, Rashid Mahmood Khan, Fatima Afzal, Ghulam M. Mustafa, Aftab Ahmad, Shahid M. Ramay, Asif Mahmood, Syed Mansoor Ali, Shahid Atiq
Summary: CNTs-TiO2 nanocomposites were synthesized using the hydrothermal technique. Structural and morphological analyses showed that the addition of CNTs can enhance the energy storage capacity of the nanocomposites, with the best performance observed at 0.5wt.% of CNTs.
Article
Chemistry, Analytical
Yongfeng Chen, Yufeng Sun, Geoffrey I. N. Waterhouse, Huiju Gao, Zhixiang Xu
Summary: In this study, a highly selective molecularly imprinted gel (MIG)-based electrochemical sensor was developed for simultaneous detection of vanillin (VAN) and tartrazine (TZ) in foods. The sensor showed a linear response over the concentration range of 0.03-125 mu M, with detection limits of 0.006 mu M and 0.005 mu M for VAN and TZ, respectively. The developed sensor demonstrated excellent recoveries (92.2%-109.7%) when applied to analyze liqueur, white vinegar, and vanilla ice cream samples spiked with VAN and TZ.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Meng Yang, Hao Guo, Lei Sun, Ning Wu, Mingyue Wang, Fan Yang, Tingting Zhang, Junye Zhang, Zhilan Pan, Wu Yang
Summary: The carboxylated multi-walled carbon nanotubes and covalent triazine framework co-modified electrode showed good selectivity and high sensitivity for the simultaneous detection of hydroquinone and catechol. The concentrations of CC and HQ exhibited good linearity and the detection limits were 0.17 μM and 0.12 μM, respectively. The prepared electrochemical sensor can be utilized for determining contents of HQ and CC in real samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Hansini Abeysinghe, Gimhani Wickramasinghe, Susira Perera, Thusitha Etampawala
Summary: Phthalic Acid Esters (PAEs) are a common environmental pollutant that poses a significant threat to human health. The constant use of PAEs in producing plastic products has raised concerns due to their ability to leach into the environment. This study introduces a rapid PAE detection technique using a novel sensing platform called buckypaper, which shows potential for overcoming the limitations of existing methods.
Article
Electrochemistry
Sofia B. Davey, Amanda P. Cameron, Kenneth G. Latham, Scott W. Donne
Summary: This study examined the electrified interface between a planar non-porous glassy carbon electrode and a 0.5 M Na2SO4 aqueous electrolyte using SPECS and EIS techniques, providing insights into the variation of capacitance across the potential window and the role of EIS frequency in determining capacitance. The results highlighted the impact of mass transport on the amount of charge storage at the interface, showing the dynamics of interface formation and structure.
ELECTROCHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
V. M. Pyeshkova, O. Y. Dudchenko, O. O. Soldatkin, S. A. Alekseev, T. Seker, B. Akata Kurc, S. V. Dzyadevych
Summary: A new three-enzyme lactose amperometric biosensor was developed based on a platinum disc electrode modified by a nanosized semipermeable poly (meta-phenylenediamine) film. The optimized electropolymerization conditions of meta-phenylenediamine resulted in a high sensitivity and selectivity of the biosensor for lactose measurement. The biosensor showed high reproducibility, sensitivity, and selectivity, making it suitable for rapid and accurate determination of lactose in milk samples.
APPLIED NANOSCIENCE
(2022)
Article
Biophysics
Emna Moujehed, Zied Zarai, Haifa Khemir, Neila Miled, Mohamed Salah Bchir, Corinne Gablin, Francois Bessueille, Anne Bonhomme, Didier Leonard, Frederic Carriere, Ahmed Aloulou
Summary: The study showed that using LIP2 lipase from Yarrowia lipolytica (YLLIP2) can effectively degrease sheepskins, reducing the need for harmful chemicals in the leather industry. The enzymatic treatment produced higher quality leather compared to chemical treatment, with cleaner effluent physicochemical parameters. This opens up new possibilities for a more efficient and environmentally friendly approach in leather production.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Meryem Belkilani, Carole Farre, Yves Chevalier, Sylvain Minot, Francois Bessueille, Adnane Abdelghani, Nicole Jaffrezic-Renault, Carole Chaix
Summary: In this study, a phospholipid-based liposome layer was used as a biomimetic membrane model to investigate the binding between the pH-dependent fusogenic peptide from the influenza virus and the liposomes. The interaction was monitored using a multiparameter surface plasmon resonance approach, and it was found that the peptide could enter the lipid bilayer of liposomes at acidic pH, inducing vesicle swelling, while no insertion of the peptide was observed at alkaline pH, causing liposome contraction.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Hamdi Ben Halima, Francesca G. Bellagambi, Marie Hangouet, Albert Alcacer, Norman Pfeiffer, Albert Heuberger, Nadia Zine, Joan Bausells, Abdelhamid Errachid
Summary: In this study, a salivary Interleukin-10 detection strategy was proposed for multi-detection of Heart Failure biomarkers using an easily integrable Lab-on-Chip and Point-of-Care IMFET. The developed IMFET showed good linearity and high selectivity towards IL-10 in both standard solutions and real saliva samples. The precision of the IMFET was also evaluated and the results were accurate.
Article
Materials Science, Multidisciplinary
Antoine Bard, Sylvain Minot, Clementine Symonds, Jean-Michel Benoit, Alban Gassenq, Francois Bessueille, Bruno Andrioletti, Camilo Perez, Kevin Chevrier, Yannick De Wilde, Valentina Krachmalnicoff, Joel Bellessa
Summary: A new method of hybridizing two materials and transferring energy through a surface plasmon over micrometric distances is proposed in this paper. The energy transfer mechanism is observed and evaluated through experiments.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Analytical
Hamdi Ben Halima, Francesca G. Bellagambi, Fabien Brunon, Albert Alcacer, Norman Pfeiffer, Albert Heuberger, Marie Hangouet, Nadia Zine, Joan Bausells, Abdelhamid Errachid
Summary: A silicon nitride based Immuno field-effect transistor (ImmunoFET) was proposed for quantifying salivary cortisol to monitor heart failure progression. The device showed a linear response, high sensitivity, and accurate quantification of cortisol in saliva samples.
Article
Chemistry, Analytical
Pouyan Razmshoar, S. Hajir Bahrami, Mohammad Rabiee, Isaac A. M. Frias, Marie Hangouet, Marie Martin, Francois Bessueille, Abdelhamid Errachid, Nicole Jaffrezic-Renault
Summary: A study was conducted to develop an impedimetric immunosensor for the detection of interleukin-10 cytokine using electrospun polystyrene fibers and polyamidoamine dendritic polymer on a gold electrode. Experimental results showed that the immunosensor exhibited good sensitivity, selectivity, and stability.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sylvain Minot, Corinne Gablin, Alban Gassenq, Antoine Bard, Clementine Symonds, Jean -Michel Benoit, Joel Ballessa, Didier Leonard, Francois Bessueille
Summary: Layer-by-layer self-assembly and micro-nanostructured surface preparation techniques can be combined to achieve dye transfer, and surface analysis imaging techniques can provide valuable information for the development of this process.
Article
Chemistry, Analytical
Hamdi Ben Halima, Francesca G. Bellagambi, Marie Hangouet, Albert Alcacer, Norman Pfeiffer, Albert Heuberger, Nadia Zine, Joan Bausells, Abdelhamid Elaissari, Abdelhamid Errachid
Summary: Heart failure is a chronic cardiovascular disease that is a major cause of mortality globally, especially for the elderly. N-terminal pro-brain natriuretic peptide (NT-proBNP) has been identified as the gold standard biomarker for diagnosing and monitoring heart failure. Saliva analysis has emerged as a powerful tool for clinical applications, and electrochemical immunosensors have shown potential in detecting clinical biomarkers. This study developed an immunologically modified Field effect Transistor (IMFET) to detect NT-proBNP in saliva samples, demonstrating good selectivity, sensitivity, and accuracy.
Article
Chemistry, Analytical
Hamdi Ben Halima, Abdoullatif Baraket, Clara Vinas, Nadia Zine, Joan Bausells, Nicole Jaffrezic-Renault, Francesc Teixidor, Abdelhamid Errachid
Summary: A liquid PVC membrane doped with the ion-pair tetracycline/theta-shaped anion was developed as an antibody-free sensing membrane for tetracycline detection. The membrane showed a high sensitivity, with a detection limit of 0.3 pg/L. It outperformed other tetracycline antibiotics and had a shelf-life over six months. The membrane was successfully used for detecting tetracycline in spiked honey samples.
Article
Chemistry, Analytical
Waralee Ruankham, Isaac Aaron Morales Frias, Kamonrat Phopin, Tanawut Tantimongcolwat, Joan Bausells, Nadia Zine, Abdelhamid Errachid
Summary: Sensitive and accurate approaches for cardiac biomarker monitoring in heart failure patients are currently required. A novel aptasensor was developed based on the advantages of aptamers over traditional antibodies, utilizing a single-step impedimetric NT-proBNP-modified gold microelectrode array. The sensor exhibited linear electroimpedimetric signals to NT-proBNP concentrations in the range of 5.0 x 10-3 to 1.0 pg mL-1, with a low detection limit of 5.0 x 10-3 pg mL-1. Clinically relevant detection levels for NT-proBNP were achieved in a simple, rapid, and label-free measurement using artificial saliva, demonstrating its potential as a safe, non-invasive, affordable, and accessible point-of-care tool.
Article
Chemistry, Analytical
Nazha Hilali, Waralee Ruankham, Isaac Aaron Morales Frias, Francesca G. Bellagambi, Marie Hangouet, Marie Martin, Joan Bausells, Hasna Mohammadi, Aziz Amine, Nadia Zine, Abdelhamid Errachid
Summary: The aim of this study was to develop an electrochemical biosensor for determining salivary interleukin-10 (IL-10) levels. The use of copper-free click chemistry improved the biofunctionalization strategy and led to the successful development of the sensor. The immunosensor showed a semi-logarithmic linear range from 0.1 pg/mL to 5 pg/mL with an R2 value of 0.9815, a limit of quantitation (LOQ) of 0.1 pg/mL, and a relative standard deviation (RSD) of 10.67%. The specificity of the immunosensor was confirmed, and it was successfully applied to the analysis of saliva samples from a healthy volunteer.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Anis Madaci, Patcharapan Suwannin, Guy Raffin, Marie Hangouet, Marie Martin, Hana Ferkous, Abderrazak Bouzid, Joan Bausells, Abdelhamid Elaissari, Abdelhamid Errachid, Nicole Jaffrezic-Renault
Summary: In this paper, a microconductometric sensor based on a chitosan composite including alcohol dehydrogenase, its cofactor, and gold nanoparticles was designed and calibrated. The presence of gold nanoparticles significantly improved the response time, sensitivity, selectivity, and reproducibility of the ethanol sensor. Compared to without gold nanoparticles, the response time was reduced to 10 s, sensitivity was 11.3 times higher, selectivity factor versus methanol was three times higher, and relative standard deviation was significantly lower.
Article
Biophysics
Nazha Hilali, Marie Hangouet, Joan Bausells, Karolin Kern, Lisbeth Ramirez-Caballero, Michael Szardenings, Cristina Polonschii, Hasna Mohammadi, Aziz Amine, Nadia Zine, Abdelhamid Errachid
Summary: A silicon-based microchip coupled with click-chemistry bound peptides was developed to specifically detect anti-nut related IgGs in rabbit sera. The chosen peptides showed promising differentiation abilities and could potentially be used for multivariable detection of anti-allergens in blood sera.
BIOSENSORS & BIOELECTRONICS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
E. Amat, A. del Moral, V. Soler, J. Bausells, F. Perez-Murano
Summary: This paper introduces a method to realize a CMOS inverter by stacking metal and inter-metal layers around a vertical nanowire. The suitability of this proposal is proved and the influence of different device design parameters on its performance is analyzed using Sentaurus 3D TCAD simulations.
2022 IEEE 22ND INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (NANO)
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
