Article
Chemistry, Analytical
Hyeong-Min Kim, Hyo-Jun Kim, Jae-Hyoung Park, Seung-Ki Lee
Summary: This study combines sandwich immunoassay with fiber-optic localized surface plasmon resonance (FO LSPR) for real-time and high-sensitivity analysis of low-concentration targets. By using second antibody-second gold nanoparticle conjugates, the detection limit is significantly enhanced and has good selectivity. The practical applicability of this method in detecting patient serum is confirmed and compared with a commercial assay kit.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Electrical & Electronic
Yumei Zhang, Liyun Ding, Jue Zhao, Xingdong Jiang, Fei Ma
Summary: Acetylcholine is an important neurotransmitter that can be detected using a simple electrostatic interaction to create an optical fiber biosensor. The biosensor has high sensitivity and a linear range, making it more convenient, simple, and cost-effective compared to traditional detection methods.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Chang-Yue Chiang, Chien-Hsing Chen, Chin-Wei Wu
Summary: In this study, a facile method using carboxymethyl dextran modified gold nanoparticles and a fiber optic localized surface plasmon resonance biosensor was developed for the rapid and sensitive detection of HMGB1 as a biomarker of chronic inflammation. The FOLSPR sensor exhibited a wide linear range, fast response time, low detection limit, and high correlation coefficient values. The accurate quantification and reliable validation of kinetic binding events demonstrated the potential of this approach in clinical applications.
Article
Biochemical Research Methods
Loan Thi Ngo, Wei-Kai Wang, Yen-Ta Tseng, Ting-Chou Chang, Pao-Lin Kuo, Lai-Kwan Chau, Tze-Ta Huang
Summary: A new biosensing method utilizing MutS protein and fiber optic particle plasmon resonance (FOPPR) sensing system has been developed to detect gene mutations with high sensitivity (limit of detection down to 0.49 nM) and short analysis time (as short as 15 min). Validation using patient samples has shown accurate determination of allelic fraction, making this method a promising tool for detecting single nucleotide polymorphisms in biological samples at point-of-care sites.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mengdi Lu, Wei Peng, Ming Lin, Fang Wang, Yang Zhang
Summary: A self-assembled templating technique using block copolymer layer was proposed for LSPR sensors, resulting in a high uniformity and density of gold nanoparticle monolayer. The performance in LSPR resonance wavelength and refractive index sensitivity significantly improved compared to conventional techniques, with a notable decrease in detection limit.
Article
Spectroscopy
Hyeong-Min Kim, Jae-Hyoung Park, Seung-Ki Lee
Summary: FO LSPR sensors are limited by the small area of the substrate, and enhancing interactions between plasmonic nanostructures can improve sensor sensitivity. By using dimers, the interaction between light and nanostructures is effectively increased, resulting in improved performance of the FO LSPR sensors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Vivek Semwal, Oliver Rishoj Jensen, Ole Bang, Jakob Janting
Summary: This paper presents numerical and experimental results on the effects of spherical gold nanoparticles (AuNPs) size on Localized Surface Plasmon Resonance (LSPR) refractive index (RI) sensitivity, Figure of Merit (FoM), and penetration depth (dp). The study also investigates the influence of AuNP dimer interparticle distance (ds) on these parameters. The results show that a diameter of 60 nm AuNPs provides the best FoM. Furthermore, the interparticle distance between d = 20 nm and 60 nm AuNPs significantly affects the RI sensitivity. The importance of penetration depth information for biosensing using aptamers is discussed in relation to aptamer size.
Article
Chemistry, Analytical
Zewei Luo, Ya Xu, Lu He, Fan He, Juan Wu, Zhijun Huang, Yonghui Tian, Yongxin Li, Yixiang Duan
Summary: The study presented a novel LSPR-based cytosensor using Omega-shaped fiber optic with suitable AuNPs coverage, which showed high sensitivity and rapid detection for cancer cells, indicating promising applications in cancer diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yeseren Saylan
Summary: This study develops a biomimetic optic sensor for detecting Enterococcus faecalis in drinking water. The sensor utilizes a molecularly imprinted nanofilm made of gold nanoparticles. Extensive characterization shows that the sensor has remarkable detection capabilities with a low detection limit of 6.6x103 cfu/mL and a high determination coefficient within the Enterococcus faecalis concentration range of 5x104 - 1x108 cfu/mL. Importantly, the sensor is effective not only in buffer solutions but also in water sample solutions, making it practical for real-world applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Caroline Tochetto, Dennis M. M. Junqueira, Tavis K. K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. E. Cantao, Amy L. Vincent L. Baker, Rejane Schaefer
Summary: Through surveillance and analysis of swine herds in Brazil, it was found that human seasonal influenza viruses have entered the pig population at least eight different times, leading to the formation of distinct genetic subgroups. Bidirectional transmission between humans and pigs is a major contributing factor to the global genetic diversity of swine influenza viruses, highlighting the importance of surveillance.
Article
Chemistry, Analytical
Xin Li, Fei Wang, Xue Wang, Wenjie Zhao, Hongyao Liu, Mingxiao Li, Yang Zhao, Lingqian Zhang, Chengjun Huang
Summary: This article introduces a novel plasmonic-photonic hybrid configuration for fiber-optic sensors, which integrates a dielectric coating and dispersed gold nanoparticles onto the fiber tip. This configuration enhances sensing performance and simplifies the fabrication process. By coupling localized surface plasmon resonance with cavity interference mode, a hybrid plasmonic-photonic resonance is successfully excited with enhanced sensitivity, high stability, and precise tunability of resonance frequencies. Experimental results demonstrate real-time monitoring of biomolecular binding interactions at nanomolar concentration, showcasing the potential of this plasmonic-photonic configuration in developing miniaturized high-performance sensing probes.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Nilay Bereli, Monireh Bakhshpour, Aykut Arif Topcu, Adil Denizli
Summary: In this study, an SPR-based immunosensor utilizing amine-functionalized gold nanoparticles was developed for IgM antibody detection in aqueous solution and artificial plasma, demonstrating high sensitivity and detection limits. Additionally, the immunosensor showed good reusability and was validated using the ELISA method.
Article
Nanoscience & Nanotechnology
Ming Lin, Mengdi Lu, Yuzhang Liang, Li Yu, Wei Peng
Summary: Localized surface plasmon resonance (LSPR) and lossy mode resonance (LMR) are simultaneously excited by gold nanoparticle (AuNP) arrays and top-coated polyelectrolyte layer on optical fibers, enhancing the sensitivity of the optical sensor. Thicker polyelectrolyte layer leads to higher refractive index sensitivity, and the optimized sensor with 50 nm AuNPs and 20 PAH/PSS bilayers shows improved stability and sensitivity.
ACS APPLIED NANO MATERIALS
(2022)
Article
Virology
Pan Tang, En-hui Cui, Wen-chi Chang, Chen Yu, Hao Wang, En-qi Du, Jing-yu Wang
Summary: This study evaluated the protective efficacy of a novel nanoparticle swine influenza vaccine in mice. The vaccine induced high levels of antibodies and efficient cytokine levels in mice, reducing viral loads and pathological damage. The findings suggest that this vaccine candidate can induce robust immunity and provide broad protection against drifted subtypes.
Article
Biochemistry & Molecular Biology
Zih-Syuan Yang, Szu-Wei Huang, Wen-Hung Wang, Chih-Yen Lin, Chu-Feng Wang, Aspiro Nayim Urbina, Arunee Thitithanyanont, Sung-Pin Tseng, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: DC-SIGN is a C-type lectin expressed in dendritic cells, which has been reported to mediate viral infections. This study identified two essential N-glycosylation sites (N27 and N39) in HA proteins of H5N1-AIVs crucial for DC-SIGN mediated infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Szu-Wei Huang, Sorin O. Miller, Chia-Hung Yen, Sheng-Fan Wang
Summary: The D614G mutation in the SARS-CoV-2 spike protein has been shown to increase the virus's ability to bind to ACE2 receptors, leading to higher transmission efficiency. This mutation became prevalent in Europe and North America but not in China, possibly due to variations in human population genetics. The higher ACE2 expression in Asian populations compared to other populations suggests that genetic diversity plays a role in the adaptive evolution of SARS-CoV-2, impacting public health interventions during the pandemic.
Review
Biochemistry & Molecular Biology
Szu-Wei Huang, Sheng-Fan Wang
Summary: The genetic diversity of SARS-CoV-2 and human populations plays a crucial role in determining the transmissibility and severity of COVID-19. The emergence of new variants with mutations in the spike protein could lead to immune escape and enhanced binding with ACE2, affecting virus entry into cells. Genetic variations in host proteins like ACE2 and TMPRSS2 may influence susceptibility to SARS-CoV-2 and impact the development of antiviral treatments and vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Supasek Kongsomros, Suwimon Manopwisedjaroen, Jarinya Chaopreecha, Sheng-Fan Wang, Suparerk Borwornpinyo, Arunee Thitithanyanont
Summary: Viruses have developed direct cell-to-cell transfer strategies for rapid and efficient entry into target cells, with the H5N1 influenza virus demonstrating faster cell-to-cell transmission than the human influenza H1N1 virus. Plasma membrane exchange (trogocytosis) between infected donor cells and uninfected recipient cells facilitates the intercellular transfer of viral material, with H5N1 virus inducing higher levels of trogocytosis and explaining its faster transmission rate.
Review
Infectious Diseases
Chung-Hao Huang, Yu-Te Tsai, Seng-Fan Wang, Wen-Hung Wang, Yen-Hsu Chen
Summary: Development of efficient dengue vaccines is still lacking despite the presence of licensed vaccines like CYD-TDV. Efforts are being made to improve vaccine efficacy and eliminate the risk of severe dengue through heterologous prime-boost regimens. Additionally, the absence of an ideal animal model remains a challenge in dengue vaccine development.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Editorial Material
Microbiology
Wen-Hung Wang, Arunee Thitithanyanont, Aspiro Nayim Urbina, Sheng-Fan Wang
Article
Microbiology
Szu-Wei Huang, Aspiro Nayim Urbina, Yi-Ming Arthur Chen, Sheng-Fan Wang
Summary: This study found that age is an important factor correlated with the duration of SARS-CoV-1 protective antibody existence status.
Article
Infectious Diseases
Szu-Wei Huang, Mei-Chen Shen, Wen-Hung Wang, Wei-You Li, Jen-Hsien Wang, Cheng-Yin Tseng, Po-Yu Liu, Lih-Shinn Wang, Yu-Lin Lee, Yi-Ming Arthur Chen, Chun-Yuan Lee, Po-Liang Lu, Sheng-Fan Wang
Summary: The prevalence of TDR among HIV-1-infected patients in Taiwan is increasing, with NNRTI-related mutations being the most common. A higher baseline HIV-1 viral load and receiving InSTI-based regimens are associated with shorter time to virological failure or longer time to viral suppression in this population.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Paulina Kaplonek, Ling Yao, Katrin Reppe, Franziska Voss, Thomas Kohler, Friederike Ebner, Alexander Schaefer, Ulrike Blohm, Patricia Priegue, Maria Braeutigam, Claney L. Pereira, Sharavathi G. Parameswarappa, Madhu Emmadi, Petra Menova, Martin Witzenrath, Sven Hammerschmidt, Susanne Hartmann, Leif E. Sander, Peter H. Seeberger
Summary: Streptococcus pneumoniae infections are a major cause of child mortality worldwide. Current vaccines are ineffective in providing adequate protection, leading to new disease-causing serotypes. This study presents a two-pronged vaccine approach combining S. pneumoniae proteins with a synthetic oligosaccharide, which successfully inhibits colonization and reduces disease severity. This opens up possibilities for the development of broadly cross-protective pneumococcal vaccines.
Editorial Material
Virology
Wen-Hung Wang, Arunee Thitithanyanont, Sheng-Fan Wang
Article
Virology
Chih-Yen Lin, Aspiro Urbina, Wen-Hung Wang, Arunee Thitithanyanont, Sheng-Fan Wang
Summary: Viral assembly and budding are the final and crucial steps of the virus life cycle, regulated by virus-host interaction. Many viruses exploit their late assembly (L) domains to manipulate host machinery for replication.
Article
Infectious Diseases
Zih-Syuan Yang, Chih-Yen Lin, Aspiro Nayim Urbina, Wen-Hung Wang, Wanchai Assavalapsakul, Sung-Pin Tseng, Po-Liang Lu, Yen -Hsu Chen, Ming-Lung Yu, Sheng-Fan Wang
Summary: This study reported the first case of monkeypox virus infection in Taiwan and emphasized the importance of active surveillance, enhancing border control, and the development of vaccines and antiviral drugs for preventing and controlling monkeypox disease.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Tsung-Ying Yang, Wei-Chun Hung, Tsung-Han Tsai, Po-Liang Lu, Sheng-Fan Wang, Liang-Chun Wang, Yu-Tzu Lin, Sung-Pin Tseng
Summary: This study revealed the in vitro activities, mechanisms, and in vivo study of AS101 against carbapenemase-producing E. coli (CPEC). Our finding provided further evidence for the antibiotic development of AS101.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Chien-Tzu Huang, Ching-Ping Lee, Tzu-Yin Chen, Yi-Chang Liu, Shih-Feng Cho, Jeng-Shiun Du, Ming-Lung Yu, Chung-Feng Huang, Sheng-Fan Wang, Hui-Hua Hsiao
Summary: In this prospective study, the serological responses to booster COVID-19 vaccines were evaluated in Taiwanese patients with hematologic malignancies. The majority of patients achieved seroconversion after booster doses, but exhibited reduced effective neutralization compared to healthy individuals. Lack of B-cell-targeted agents and higher immunoglobulin levels were identified as independent predictors for effective neutralization.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zih-Syuan Yang, Wen-Hung Wang, Yu-Ting Lin, Chih-Yen Lin, Aspiro Nayim Urbina, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: This study investigates the individual and collaborative roles of DC-SIGN and Gal3 in H5N1 and H7N9 avian influenza virus (AIV) infection. It is found that DC-SIGN expression significantly promotes viral infection, while Gal3 knockdown reduces viral infection. The co-expression of DC-SIGN and Gal3 enhances infectivity of H5N1 and H7N9 viruses, with stronger regulatory capabilities for H5N1. The study reveals the significance of DC-SIGN and Gal3 in regulating AIV infection and suggests the potential of targeting their interaction with HA protein as antiviral strategies.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)