Article
Pharmacology & Pharmacy
Haoyue Hu, Songtao Tan, Meng Xie, Peng Guo, Qiang Yu, Juan Xiao, Kangrui Zhao, Qiong Liao, Yi Wang
Summary: In non-small cell lung cancer, concurrent genetic alterations of epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are rare, but their clinical and pathological characteristics are not well-defined, and the optimal treatment approach remains controversial. This report presents a case of stage IV lung adenocarcinoma with both EGFR and ALK mutations, along with high PD-L1 expression. The patient initially received treatment with EGFR tyrosine kinase inhibitors (TKIs), but the disease progressed, and regression was achieved following a switch to ALK-TKI therapy and local radiotherapy. Our report also provides a comprehensive summary of the clinical and pathological features, as well as treatment strategies, for NSCLC patients with concurrent EGFR mutation and ALK rearrangement.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Martin Filipits, Verena Kainz, Viktor Sebek, Herwig Zach, Liquid Biopsy Collaborative Study Grp
Summary: Liquid biopsy is a powerful tool to detect EGFR T790M mutation; there are various platforms with different sensitivities; if a negative result is obtained from a low sensitivity method, further testing or tissue biopsy should be performed to identify T790M positive patients for optimal second-line treatment with third-generation EGFR TKI.
Review
Chemistry, Medicinal
Xin Sun, Shan Xu, Zunhua Yang, Pengwu Zheng, Wufu Zhu
Summary: EGFR, as a receptor for EGF, is closely related to the inhibition of tumor cell proliferation, invasion, and apoptosis, making it an important anti-tumor target. Small molecule inhibitors targeting EGFR have become crucial biologically active compounds for cancer treatment, especially against NSCLC. Despite significant progress in developing selective EGFR inhibitors, there is still an urgent need for new EGFR inhibitors that are safe, efficient, selective, and low-toxic to avoid adverse pharmacokinetics associated with wild-type EGFR.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)
Review
Oncology
Dan Yan, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Summary: MERTK and AXL are abnormally expressed in the majority of NSCLCs, providing a survival advantage for cells and correlating with metastasis, drug resistance, and disease progression. Host tumor infiltrating cells' TAM receptors also play crucial roles in the immunosuppressive tumor microenvironment. These factors make MERTK and AXL attractive targets for NSCLC treatment.
Article
Oncology
Chaelin Lee, Miso Kim, Dong-Wan Kim, Tae Min Kim, Soyeon Kim, Sun-Wha Im, Yoon Kyung Jeon, Bhumsuk Keam, Ja-Lok Ku, Dae Seog Heo
Summary: This study reveals that the T790M mutation in EGFR-KDD confers resistance to 1st and 2nd generation EGFR tyrosine kinase inhibitors (TKIs), but is sensitive to 3rd generation EGFR TKIs. In addition, the study identifies that the C797S mutation in kinase domain 2 of EGFR-KDDT790M mediates a resistance mechanism against 3rd generation EGFR TKIs.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Xiaotong Qiu, Yong Wang, Fen Liu, Lihong Peng, Chen Fang, Xiaoyin Qian, Xinwei Zhang, Qian Wang, Zhehao Xiao, Renfang Chen, Shangkun Yuan, Yong Li
Summary: Studies have shown that non-small cell lung cancer patients with EGFR mutations, but with concurrent PIK3CA mutations, treated with EGFR-TKIs have a shorter time to progression and lower overall survival rates.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Zhenrui Xue, Minli You, Ping Peng, Haoyang Tong, Wanghong He, Ang Li, Ping Mao, Ting Xu, Feng Xu, Chunyan Yao
Summary: The study aimed to develop a simple and highly specific qPCR-based single-base mutation detection method, which successfully established the Taqman-MGB nanoPCR system by adding different concentrations of gold nanoparticles, improving the specificity of mutation detection with a performance of detecting mutations as low as 0.95%.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biology
Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu
Summary: The small molecule compound D6 demonstrates promising efficacy in treating EGFR-TKI resistant NSCLC by targeting the protein-protein interaction between HSP90 and T790M-EGFR, offering a potential alternative strategy to overcome drug resistance.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Misako Nagasaka, Vijendra Singh, Yasmine Baca, Ammar Sukari, Chul Kim, Hirva Mamdani, Alexander Spira, Dipesh Uprety, Gerold Bepler, Edward S. Kim, Luis E. Raez, Sachin Gopalkrishna Pai, Chukwuemeka Ikpeazu, Matthew Oberley, Rebecca Feldman, Joanne Xiu, W. Michael Korn, Antoinette J. Wozniak, Hossein Borghaei, Stephen Liu
Summary: HER2 alterations can lead to resistance to EGFR tyrosine kinase inhibitors in NSCLC patients. Among the 12,946 samples analyzed, 2.5% had HER2 alterations, with 1.5% of EGFR mutated patients also having concurrent HER2 alterations. Patients with both EGFR mutation and HER2 amplification had longer time on treatment with EGFR TKIs compared to those with EGFR mutation alone. It is important to continue gathering clinical data for further analysis of real-world outcomes.
CLINICAL LUNG CANCER
(2022)
Article
Immunology
How-Wen Ko, Shian-Sen Shie, Chih-Wei Wang, Chi-Tsun Chiu, Chih-Liang Wang, Tsung-Ying Yang, Shou-Chu Chou, Chien-Ying Liu, Chih-Hsi Scott Kuo, Yu-Ching Lin, Li-Fu Li, Cheng-Ta Yang, Chin-Chou Wang
Summary: This study identifies a comprehensive spectrum of uncommon EGFR mutations and demonstrates a positive relationship between smoking status and the frequency of uncommon EGFR mutations, particularly complex uncommon EGFR mutations. The results suggest that smoking contributes to the development of complex EGFR mutations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Petr Makhov, Igor Bychkov, Bulat Faezov, Alexander Deneka, Alexander Kudinov, Emmanuelle Nicolas, Rohan Brebion, Eleanor Avril, Kathy Q. Cai, Leonid V. Kharin, Mark Voloshin, Elena Frantsiyants, Nikolay Karnaukhov, Oleg I. Kit, Iuliia Topchu, Rushaniya Fazliyeva, Anna S. Nikonova, Ilya G. Serebriiskii, Hossein Borghaei, Martin Edelman, Essel Dulaimi, Erica A. Golemis, Yanis Boumber
Summary: MSI2 regulates EGFR protein expression in non-small cell lung cancer, and depletion of MSI2 can affect proliferation of EGFR(mut) cells and response to EGFR-targeting drugs, suggesting inhibition of MSI2 could be clinically valuable in EGFR(mut) NSCLC.
Article
Oncology
Jun-Feng Liu, Xu-Sheng Sun, Jin-Huan Yin, Xi-E Xu
Summary: This retrospective study aimed to address the effect of adjuvant chemotherapy before adjuvant EGFR-TKI therapy and the duration of EGFR-TKI therapy on survival outcomes in patients with NSCLC. The results showed that adjuvant EGFR-TKI treatment was effective for patients with stage II-IIIA EGFR-mutation positive NSCLC. Patients with stage I and pathological risk factors were also suitable for receiving adjuvant EGFR-TKI therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Alex Yang-Hao Yu, Ru-Huei Fu, Shan-hui Hsu, Chen-Feng Chiu, Wei-Hsiang Fang, Chun-An Yeh, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Utilizing collagen gold nanoparticles as a carrier for EGFR siRNA shows promising results in treating lung cancer, leading to significant tumor suppression effects and improved survival rates.
MATERIALS TODAY ADVANCES
(2021)
Article
Oncology
John Wen-Cheng Chang, Chen-Yang Huang, Yueh-Fu Fang, Ching-Fu Chang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, Chiao-En Wu
Summary: This study evaluated the efficacy of EGFR-TKIs for NSCLC patients with uncommon EGFR mutations and identified prognostic factors. The results showed that afatinib demonstrated better survival outcomes than gefitinib/erlotinib for these patients.
Article
Oncology
Kai Shang, Hongxiang Huang, Yongkang Xu, Yangyang Liu, Zhihui Lu, Li Chen
Summary: This study suggests that combined treatment with EGFR-TKIs and chemotherapy can significantly improve objective response rate and time to progression in advanced NSCLC patients with an EGFR/TP53 co-mutation. For patients without brain metastases, combination therapy may be a promising treatment option.
Article
Chemistry, Multidisciplinary
Yaoqiang Hu, Kexin Li, Yuting Li, Haining Liu, Min Guo, Xiushen Ye, Zhijian Wu, Kangtaek Lee
Article
Engineering, Environmental
Seongmin Jin, Kwang-Jun Ko, Young-Geon Song, Kangtaek Lee, Chang-Ha Lee
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Engineering, Environmental
Kiju Um, Hyo-Jun Kim, Joon Hee Jo, Hyungjoon Jeon, Hye-Bin Yang, Young-Joo Kim, Kangtaek Lee
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Chemistry, Physical
Hyungjoon Jeon, Kangtaek Lee
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Engineering, Environmental
Cheolsang Yoon, Kab Pil Yang, Jungwook Kim, Kyusoon Shin, Kangtaek Lee
CHEMICAL ENGINEERING JOURNAL
(2020)
Correction
Nanoscience & Nanotechnology
Bo-Hyun Kim, Wontae Kim, Taemin Kim, Byoung Min Ko, Soon-Jik Hong, Kangtaek Lee, Jinsang Kim, Sung-Ho Song, Sunjong Lee
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Bo-Hyun Kim, Wontae Kim, Taemin Kim, Byoung Min Ko, Soon-Jik Hong, Kangtaek Lee, Jinsang Kim, Sung-Ho Song, Sunjong Lee
Summary: This study demonstrates that a fluorophore can enhance its fluorescence quantum yield through hydrogen bonding, providing a new strategy for fluorophore design. Additionally, the fluorophore embedded in a polymer matrix can selectively detect specific gases, which is crucial for the development of fluorescence sensing systems.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Ho Seok Heo, Joon Hee Jo, Seung Jun Lee, Chaemin Yun, Soo-Hyung Choi, Jun Hyup Lee, Kangtaek Lee
Summary: Quantum dot/colorless-polyimide nanocomposites were used as the color conversion layer in a light-emitting diode, and their cross-linking degree and quantum dot dispersion were controlled to enhance the efficiency and stability of the LED. The cross-linked QD/CPI nanocomposite achieved high color accuracy and a wide color gamut.
CHEMISTRY OF MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Seung-Rak Son, Jisung Park, Jun Hyup Lee, Kangtaek Lee
Summary: In this study, an environmentally friendly and scalable fabrication strategy was developed using a combination of colloidal InP quantum dots, a eutectic gallium-indium liquid metal, and size-controlled ZnO nanoparticles to produce highly efficient, environmentally friendly, solution-processable QLEDs.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Joon Hee Jo, Ho Seok Heo, Chaemin Yun, Seungho Baek, Kangtaek Lee
Summary: This study presents a novel synthesis method for the preparation of monodisperse In(Zn)P/ZnSe/ZnS quantum dots (QDs) with high photoluminescence quantum yield and stability. The formation of metastable magic-sized clusters (MSCs) during the reaction avoids the separation of nucleation and growth stages, resulting in QD cores with narrow size distribution. By employing additives (tri-n-octylphosphine and zinc chloride) during the heating-up process, the stability of MSCs is reduced, leading to decarboxylation and ligand exchange reactions. The resulting QD cores show a more uniform size distribution and improved stability due to surface passivation from the additives. The final product, In(Zn)P/ZnSe/ZnS QDs, display high photoluminescence quantum yield and narrow full-width at half-maximum, making them suitable for display applications.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Kab Pil Yang, Seung-Rak Son, Seon Hui Baek, Jun Hyup Lee, Kangtaek Lee
Summary: This study reported a method for preparing photo-patternable QD-acrylate resin for LEDs, using the addition of a comonomer and photoinitiator in the mixture followed by UV curing to fabricate nanocomposites. The optimal resin composition was found to be 1 wt% QD and a CHMA : MMA ratio of 7 : 3.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Materials Science, Multidisciplinary
Joon Hee Jo, Seung Jun Lee, Ho Seok Heo, Kangtaek Lee
Summary: The stability of InP-based quantum dots under high temperature and humidity conditions can be significantly enhanced by grafting poly(N-isopropylacrylamide) onto the quantum dots. This results in nanocomposites with improved optical properties and LED applications due to the increased affinity between the polymeric ligands and the matrix. The presence of PNIPAM-grafted quantum dots further enhances the stability of the nanocomposites against heat and moisture compared to those containing PMMA-grafted quantum dots.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Physical
Joon Hee Jo, Ho Seok Heo, Kangtaek Lee
CHEMISTRY OF MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Hyungjoon Jeon, Joon Hee Jo, Kab Pil Yang, Kangtaek Lee
JOURNAL OF MATERIALS CHEMISTRY C
(2019)
Article
Nanoscience & Nanotechnology
Hyungjoon Jeon, Cheolsang Yoon, Young-Geon Song, Junwon Han, Sujin Kwon, Seungwon Kim, Insu Chang, Kangtaek Lee
ACS APPLIED NANO MATERIALS
(2018)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)