Article
Biochemistry & Molecular Biology
Hua-jin Zeng, Li-jun Sun, Ling-bo Qu, Ran Yang
Summary: In this study, a novel glutathione functionalized MoS2 quantum dots (GSH-MoS2 QDs) were successfully synthesized with good biocompatibility and low cytotoxicity. The results showed that GSH-MoS2 QDs could effectively inhibit the aggregation of BSA and depolymerize the formed aggregates. This research suggests that GSH-MoS2 QDs have the potential to become a candidate drug for the treatment of amyloid-related diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Spectroscopy
Hua-jin Zeng, Li Sun, Si-meng Liu, Ling-bo Qu, Ran Yang
Summary: This study successfully synthesized a novel 4-mercaptophenylboronic acid functionalized MoS2 quantum dots and demonstrated their ability to inhibit protein aggregation and reduce cytotoxicity. The quantum dots showed good biocompatibility and solubility, making them potential candidates for the treatment of amyloid-related diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Optics
Huiqi Zhang, Gang Wang, Zhiming Zhang, Josh Haipeng Lei, Tzu-Ming Liu, Guichuan Xing, Chu-Xia Deng, Zikang Tang, Songnan Qu
Summary: Efficient red emissive carbon dots (CDs) were synthesized using a one-step solvothermal treatment. The CDs exhibited high photoluminescence quantum yield and multi-photon fluorescence. Composing the CDs with BSA led to enhanced red fluorescence and particle size, enabling in vivo tumor imaging and two-photon fluorescence imaging.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Chemistry, Analytical
Huiqing Yang, Qianqian Hou, Caifeng Ding
Summary: An antifouling sensing surface was constructed by crosslinking two-dimensional nanomaterial MXene with denatured bovine serum albumin (BSA), and a highly selective antifouling electrochemical biosensor was built. The biosensor, with a large specific surface area and good electrical conductivity, exhibited significantly enhanced sensitivity. Compared with BSA, the hydrogel formed through the peptide chain obtained from BSA provided a better antifouling sensing surface. The prepared biosensor quantitatively detects the concentration of IgG in complex human serum with high sensitivity.
Article
Biochemical Research Methods
Qiurong Luo, Meijun Wan, Jingqiu Zhou, Xuemei Dai, Honglin Yang, Fengjiao Zu, Yunchao Zheng, Lujun Wang
Summary: This paper reports a graphene quantum dots functionalized silica stationary phase modified with bovine serum albumin, which exhibits excellent hydrophilic interaction and separation performance, and its superior performance is validated through comparative experiments.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Physical
Qi Xiao, Xincong Tu, Huishan Cao, Huajian Luo, Bo Li, Jiajia Liu, Yi Liu, Shan Huang
Summary: This study systematically and comprehensively explored the binding interaction thermodynamics between black phosphorus quantum dots (BPQDs) and bovine serum albumin (BSA) to elucidate the effects of BPQDs on the conformational structure and biological function of BSA. Various spectroscopic strategies and molecular simulation techniques revealed that the endogenous fluorescence of BSA was spontaneously quenched by BPQDs through the static quenching mechanism involving van der Waals interaction and hydrogen bonds formation. BPQDs strongly interacted with the Sudlow's site I of BSA in a 1:1 stoichiometric ratio, forming a stable ground-state complex. Three-dimensional fluorescence spectrometry and circular dichroism spectroscopy results showed that BPQDs decreased the content of the prominent alpha-helix structure and the thermal stability of BSA in a concentration-dependent manner. These findings provide comprehensive insights into the binding interaction mechanism between BPQDs and BSA, as well as the changes in the secondary structure of BSA upon association with BPQDs. This research paves the way for the targeted design of biocompatible black phosphorus derivatives and the safe application of such nanoparticles in clinical diagnosis and effective therapy of serious human diseases.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Analytical
Yang Li, Rui Han, Min Chen, Leyao Zhang, Guixiang Wang, Xiliang Luo
Summary: An antifouling biosensing interface was constructed using cross-linked BSA and polyaniline nanowires, which exhibited enhanced antifouling capability and electrochemical activity. By immobilizing peptide aptamer for IgG recognition, an electrochemical biosensor with excellent selectivity and sensitivity was prepared, capable of accurately detecting IgG in complex biological samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Huajian Luo, Bo Li, Jiajia Liu, Yi Liu, Qi Xiao, Shan Huang
Summary: The research revealed that MoS2 QDs strongly bind with HSA, leading to conformational changes, reduced thermal stability, but also inhibition of fibrillation process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Hosna Ehzari, Meysam Safari, Mohsen Samimi, Mojtaba Shamsipur, Mohammad Bagher Gholivand
Summary: A novel biosensor was developed for rapid sensing of the chlorpyrifos pesticide. The biosensor showed high sensitivity and stability, making it a promising tool for screening trace amounts of CPS in soil and water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Lishuang Wang, Longshan Zhao
Summary: A novel dual-emission FL-MIPs sensor was constructed for naked-eye detection of BSA, showing excellent linear relationship and fluorescence color changing properties. The advantages of convenience, low cost, and wide applicability make it a promising tool in various fields.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Fuka Tabata, Yasuaki Wada, Satomi Kawakami, Kazuhiro Miyaji
Summary: Serum albumin, the most abundant circulating protein in mammals, has three isoforms based on its redox state, traditionally considered a biomarker of systemic oxidative stress but recent research indicates oxidized albumin itself may worsen pathological conditions. Experimental evidence also suggests its potential as a sensitive protein nutrition biomarker.
Article
Chemistry, Analytical
Peng Qu, Cheng-Jie Li, Jin Hu, Ge Gao, Peng Lin, Wei-Wei Zhao
Summary: Organicphotoelectrochemical transistor (OPECT) biosensing is a promising approach for biomolecular sensing. This work demonstrates the direct enzymatic biocatalytic precipitation (BCP) modulation on a flower-like Bi(2)S(3) photosensitive gate, achieving high-efficiency OPECT operation with high transconductance (g (m)). The developed OPECT aptasensor shows good analysis performance for prostate-specific antigen (PSA).
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaojun Liu, Yuanyuan Sun, Xinyi Lin, Xiaoyan Pan, Zhangjian Wu, Hongwei Gai
Summary: This paper presents a spectral imaging-based multiplex, homogenous immunoassay that was used to detect tumor biomarkers and successfully quantify model proteins in human plasma, demonstrating the accuracy and reliability of the approach.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhen Song, Rong Li, Xiqin Yang, Adriano Ambrosi, Xiliang Luo
Summary: This paper presents a simple one-step assembly method for constructing phase-transited bovine serum albumin antifouling layers, which are used for the development of antifouling electrochemical sensors. These sensors can accurately and sensitively detect uric acid in human body fluids.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Chunhua Wang, Yu Zhang, Wei Tang, Chao Wang, Yingkuan Han, Le Qiang, Jianwei Gao, Hong Liu, Lin Han
Summary: The developed universal biosensing platform combines the unique nanostructure and biochemistry properties of graphene oxide quantum dots with the high throughput and low cost of microfluidic chips, enabling reliable and simultaneous detection of multiple cancer biomarkers. This platform has a wide linear quantification range and ultra-low detection limits, allowing for simultaneous detection of multiple biomarkers from multiple individuals in a short time, significantly reducing detection costs and time.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Shichao Ding, Zhaoyuan Lyu, Erik Sarnello, Mingjie Xu, Lingzhe Fang, Hangyu Tian, Sam Ellery Karcher, Tao Li, Xiaoqing Pan, John McCloy, Guodong Ding, Qiang Zhang, Qiurong Shi, Dan Du, Jin-Cheng Li, Xiao Zhang, Yuehe Lin
Summary: In this study, a MnOx engineered Fe-N-C single-atom catalyst (Mn-Fe-N-C SAC) was developed to reduce oxidative corrosion and enhance the stability of the oxygen reduction reaction (ORR). The Mn-Fe-N-C SAC exhibited ultralow H2O2 yield and negligible potential shift after continuous potential cycles, demonstrating excellent ORR stability and improved activity compared to common Fe-N-C SACs. The interaction between MnOx and Fe-N-x sites enhanced the intrinsic activity of single iron sites, providing a promising solution for the stability issue of Fe-N-C SACs while maintaining high catalytic activity.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biophysics
Xiaofan Ruan, Victoria Hulubei, Yijia Wang, Qiurong Shi, Nan Cheng, Limin Wang, Zhaoyuan Lyu, William C. Davis, Jordan N. Smith, Yuehe Lin, Dan Du
Summary: Increased use of pesticides in agriculture requires advanced techniques to monitor environmental levels and human exposure. This study developed a new sensor for rapid detection of the major metabolite of atrazine exposure. The use of mesoporous core-shell nanoparticles and a 3D printed readout device provides a promising tool for on-site and ultrasensitive detection of pesticide biomarkers.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Analytical
Weiqing Xu, Yu Wu, Lei Jiao, Wenling Gu, Dan Du, Yuehe Lin, Chengzhou Zhu
Summary: This article summarizes the fabrication and application of MOFs-based nanozymes. Various MOFs-based nanomaterials, including pristine MOFs, functionalized MOFs, MOFs-based composites, and MOFs derivatives, are introduced, with a focus on design strategy, enzyme-like activity, and catalytic mechanisms. Their applications in various target assays are summarized, and the challenges and research directions for the development and application of MOFs-based nanozymes are provided.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xin Li, Shichao Ding, Zhaoyuan Lyu, Peter Tieu, Maoyu Wang, Zhenxing Feng, Xiaoqing Pan, Yang Zhou, Xiangheng Niu, Dan Du, Wenlei Zhu, Yuehe Lin
Summary: This work presents the design and synthesis of single-atomic iron doped carbon dots with tunable fluorescence and exceptional oxidase-mimetic activity. Phosphate ions can suppress the activity and restore the photoluminescence of the carbon dots, leading to the development of a dual-mode colorimetric and fluorescence assay for phosphate monitoring.
Article
Multidisciplinary Sciences
Zhaoyuan Lyu, Shichao Ding, Peter Tieu, Lingzhe Fang, Xin Li, Tao Li, Xiaoqing Pan, Mark H. Engelhard, Xiaofan Ruan, Dan Du, Suiqiong Li, Yuehe Lin
Summary: In this study, a single-atomic site catalyst (SASC) with excellent catalytic activity was designed to enhance the portable detection performance of herbicides. The catalyst exhibited superior peroxidase-like (POD-like) activity and was used as a label in lateral flow immunoassay (LFIA) for herbicide detection. The Fe-SASC-LFIA achieved a linear detection range of 1-250 ng/mL with a low limit of detection (LOD) of 0.82 ng/mL for 2,4-dichlorophenoxyacetic acid (2,4-D). The method demonstrated excellent specificity and selectivity towards 2,4-D and showed promising results in the detection of human urine samples, indicating its potential as a portable and high-sensitive point-of-care (POC) detection strategy for pesticide exposure evaluation.
Article
Chemistry, Physical
Shichao Ding, Lin He, Lingzhe Fang, Yuanzhi Zhu, Tao Li, Zhaoyuan Lyu, Dan Du, Yuehe Lin, Jin-Cheng Li
Summary: This study proposes a carbon nanotube-bridging strategy to synthesize a highly efficient oxygen electrocatalyst for the development of high-performance and long-life rechargeable zinc-air batteries. The results show that the developed catalyst exhibits good electrochemical performance and cycle stability.
ADVANCED ENERGY MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Guohai Yang, Fanglei Liu, Jiayi Zhao, Lijie Fu, Yingqiu Gu, Lulu Qu, Chengzhou Zhu, Jun-Jie Zhu, Yuehe Lin
Summary: In this review, the latest research on MXenes in the fields of biosensing and biomedicine is summarized. The synthesis strategies and unique properties of MXenes are introduced, and the biosensing applications of MXenes are divided into three subcategories based on the sensing mechanism: electrochemical, photochemical, and opto-electrochemical biosensors. The biomedical applications of MXenes are evaluated from four aspects: antibacterial activity, bioimaging, therapeutics, and theranostics. The specific chemical and physical properties of MXenes that influence the efficiency of biosensing and biomedicine are highlighted, as well as the structure-performance relationships determining detection sensitivity and material toxicity. The challenges, future prospects, and opportunities for MXenes are discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Xiao-Qian Zhang, Zhaoyuan Lyu, Shichao Ding, Shiyong Zhao, Guangyu Chen, Yuehe Lin, Jin-Cheng Li
Summary: A molten-salt-assisted pyrolysis strategy was used to prepare two-dimensional porous metal-nitrogen/carbon materials with exposed metal-nitrogen sites, which showed excellent performance in both liquid-state and solid-state Zn-air fuel cells.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Juan Liu, Xiaoxiao Guo, Zhaoyuan Lyu, Rong-Bin Song, Pengyu Zhou, Shichao Ding, Yang Zhou, Li-Ping Jiang, Yuehe Lin, Wenlei Zhu
Summary: By using copper electrocatalysts and microorganisms, an electro-bio tandem reactor was designed to convert CO2 into specific multicarbon compounds in both the gas and liquid phases. The reducing products from electrocatalysis can be consumed and recycled for selective acetate synthesis in Moorella thermoacetica. The results showed high faradaic selectivity for acetate in liquid products for Cu-based CO2 electroreduction and high electron conversion rate to ethylene and acetate for microbial electrosynthesis, presenting a green design for CO2 upcycling targeting multicarbon products through the parallel integration of electrocatalysis and fermentation.
Review
Chemistry, Multidisciplinary
Weiqing Xu, Yu Wu, Wenling Gu, Dan Du, Yuehe Lin, Chengzhou Zhu
Summary: Metal-organic frameworks (MOFs) have made significant advances as mimics of metalloenzymes in bioinspired catalysis, particularly in the field of active pocket engineering at the atomic level.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Yifan Chai, Zhaoyuan Lyu, Huitong Du, Pan Li, Shichao Ding, Yujing Jiang, Hua Wang, Qianhao Min, Dan Du, Yuehe Lin, Wenlei Zhu
Summary: This article introduces the fermentative hydrogen production method for biohydrogen and explores the principles of microbial dark fermentation and photo-fermentation in depth. It summarizes the strategies to increase the efficiency of fermentative hydrogen production and describes some recent representative works.
Article
Chemistry, Multidisciplinary
Shuo Feng, Rajesh Kumar Singh, Yucheng Fu, Zhuo Li, Yulong Wang, Jie Bao, Zhijie Xu, Guosheng Li, Cassidy Anderson, Lili Shi, Yuehe Lin, Peter G. Khalifah, Wei Wang, Jun Liu, Jie Xiao, Dongping Lu
Summary: In this study, a simple strategy was demonstrated for constructing low-tortuosity through-pores in both vertical and planar directions of electrodes by casting large particles into single-particle-layer electrodes. Through multi-scale characterizations and simulations, correlations between material/electrode structures, electrolyte permeability, polysulfide migration, and sulfur reactions were elucidated. The high-loading and dense sulfur cathode fabricated by this method delivers a high specific capacity at a very low electrolyte/sulfur ratio.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yu Wu, Weiqing Xu, Lei Jiao, Wenling Gu, Dan Du, Liuyong Hu, Yuehe Lin, Chengzhou Zhu
Summary: Enzymes have great potential in various fields due to their high activity and specificity for catalysis under mild conditions. However, they struggle to adapt to different environments outside of their familiar biological conditions. Nanobiocatalysis, which integrates nanotechnology and enzymatic catalysis, aims to design biocatalysis based on materials science. Nano-integrated biocatalysis and bio-inspired nanocatalysis are two effective nanobiocatalytic systems that can meet different design needs, and their combination opens up even more possibilities. This review summarizes the types, constructions, and functions of nanobiocatalytic systems, analyzing the pros and cons of different strategies. Additionally, it highlights their applications in bioassay, biotherapy, and environmental remediation.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Hangyu Tian, Wenlei Zhu, Qiurong Shi, Shichao Ding, Zhaoyuan Lyu, Mingjie Xu, Xiaoqing Pan, Mark H. Engelhard, Du Dan, Yuehe Lin
Summary: This work presents a facile method for synthesizing robust Ir-based bimetallic MNNs by chemical reduction. The optimized IrxPb catalyst delivers an enhanced oxygen evolution reaction (OER) performance in acid media, superior to that of the commercial IrO2 catalyst.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
