Article
Materials Science, Multidisciplinary
Lingling Guan, Ziwei Jiang, Yuanjing Cui, Yu Yang, Deren Yang, Guodong Qian
Summary: The development of a method for discriminating typically quenching metal ions has been a great interest and challenge. By incorporating Eu3+ and DOC into MOF-253, a luminescent sensor array can successfully distinguish various metal ions with high accuracy at low concentrations, and this strategy could open up new possibilities for luminescent sensor assays.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Lingang Yang, Shumin Shen, Jie Zhu, Yuqing Zhang, Yuting Lin, Jiamin Wang, Feifei Tao, Lingzhi Wang, Jinlong Zhang
Summary: The creation of yolk-shell nanoparticles (YS NPs) with a movable core and periodic mesoporous organosilica (PMO) shell has been simplified using a self-template strategy. A ratiometric Cu2+ fluorescence sensor is created by incorporating a silver nanocore into the YS NP (Ag-PMO-YS), driven by the like dissolves like principle. Due to the coordination of Cu2+ and its ligands and their impact on the emission of fluorescein derivatives, this sensor system demonstrates extraordinary detection sensitivity to Cu2+ (10-7 M), strengthened by the movable Ag nanocore's metal-enhanced fluorescence (MEF) effect.
ACS APPLIED NANO MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Lijuan Feng, Hui Wang, Tingting Liu, Tiantian Feng, Meng Cao, Jiacheng Zhang, Tao Liu, Zhanhu Guo, Costas Galiotis, Yihui Yuan, Ning Wang
Summary: Strontium-90, a frequently released radioactive product in nuclear reactor waste, poses serious health hazards due to its long half-life and the ability to accumulate in the food chain and bones. However, its identification is challenging due to the absence of characteristic energy rays. In this study, the authors developed a biosensor that uses a fluorogenic dye, thioflavin T, to detect Sr2+ ions with high sensitivity and selectivity. This work provides a technological solution to monitor radioactive strontium pollution and contributes to the sustainability of nuclear power.
NATURE SUSTAINABILITY
(2023)
Review
Chemistry, Multidisciplinary
Xuanyu Yang, Yu Deng, Haitao Yang, Yaozu Liao, Xiaowei Cheng, Yidong Zou, Limin Wu, Yonghui Deng
Summary: With the emergence of the Internet of Things, chemiresistive gas sensors have been extensively applied in various fields such as industrial production, food safety, medical diagnosis, and environment detection. The performance of gas sensors has been improved through the tailoring of sensitive materials' structure, functions, defects, and electrical conductivity. Among these sensitive materials, mesoporous semiconductor metal oxides, with tunable pore size, high specific surface area, abundant metal-oxygen bonds, and rapid mass transfer behavior, have been considered as the most promising. This article provides an overview of the synthesis strategies for mesoporous metal oxides, summarizes the classical functionalization techniques of sensitive materials, discusses the structure-function relationship at the molecular-atomic level, and proposes challenges and future perspectives for the development of intelligent gas sensors.
Article
Chemistry, Analytical
I. G. Alhindawy, D. A. Tolan, E. A. Elshehy, W. A. El-Said, S. M. Abdelwahab, H. I. Mira, T. Taketsugu, V. P. Utgikar, A. M. El-Nahas, A. O. Youssef
Summary: This paper reports the synthesis of hierarchically structured mesoporous silica as a pH-dependent sensor for the detection and adsorption of strontium ions from radioactive strontium-contaminated water. The designed sensor based on cubical mesoporous silica monoliths enabled the detection of harmful strontium ions from drinking water. The surface-coating process created a unique pH-dependent colorant sensor. The synthesized silica sensor showed remarkable changes in color and absorbance intensity at a pH value of 10.3 for strontium ions.
Review
Chemistry, Analytical
Liangyun Yu, Liangju Sun, Qi Zhang, Yawen Zhou, Jingjing Zhang, Bairen Yang, Baocai Xu, Qin Xu
Summary: In this review, ion-imprinted electrochemical sensors (IIECSs) based on nanomaterials for heavy metal ions (HMIs) detection are discussed. The modification of electrode surfaces with nanomaterials improves the detection sensitivity and reduces the detection limit of the sensors. The fundamentals and synthetic strategies of ion-imprinted polymers (IIPs) as well as the applications of various nanomaterials as modifiers and sensitizers are highlighted in the construction of HMIIECSs and their influence on the sensing performance.
Review
Chemistry, Inorganic & Nuclear
Gen Wang, Shengjiong Yang, Li Cao, Pengkang Jin, Xiangkang Zeng, Xiwang Zhang, Jing Wei
Summary: Chemiresistive gas sensors based on semiconducting metal oxides (SMOs) are widely used in various fields, but developing sensors with high selectivity and low working temperature remains a challenge. Metal-organic frameworks (MOFs) derived SMOs have shown promise due to their mesoporous structure and unique morphology. This review systematically summarizes recent developments in this area and discusses strategies for enhancing sensing performance, such as constructing novel nanostructures and combining with highly-conductive materials.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Xu Chu, Tao Chen, Yan Cao
Summary: This paper reports a simple, rapid and sensitive fluorescence sensor using Carbon Dot (CD) as a probe for the parallel determination of Fe3+, Tb3+ and Eu3+ ions. The CD can selectively quench the fluorescence of Fe3+ through non-radiative electron-transfer and enhance the fluorescence of Tb3+ and Eu3+ through the antenna effect. The fluorescence quenching mechanism and energy transfer mechanism were also studied in details.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Yanyan Li, Keyu Chen, Yan Liu, Junhao Ma, Yaozu Liao, Haitao Yang, Jinsheng Cheng, Qin Yue, Kaiping Yuan, Yuan Ren, Yidong Zou, Yonghui Deng
Summary: Benzene derivatives, as a typical family of volatile toxic compounds, are emitted extensively in industrial production and the automobile field, posing a serious threat to human health and the environment. The reliable and convenient detection of low concentration benzene derivatives based on intelligent gas sensors is of great significance for environmental protection.
Review
Chemistry, Analytical
Selva Bilge, Leyla Karadurmus, Ali Sinag, Sibel A. Ozkan
Summary: Pollution caused by heavy metal ions, such as arsenic, cadmium, chromium, lead, and mercury, is a critical public health issue due to their high toxicity. Developing new techniques for identifying heavy metal ions is crucial, with electrochemical techniques and carbon materials being effective options for detection.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xiao Zhou, Tianlin Wang, Minyang Zhao, Pengxiang Wang, Zhe Hao, Xiaodong Lin, Shuo Wang, Yaqing Liu
Summary: The study developed a sensor array consisting of three lanthanide-based fluorescent probes for rapid discrimination of multiple metal ions, showing sensitivity to different oxidation states and excellent recovery in real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Tongtong Hou, Yue Huang, Xin Wang, Xiaoling Hu, Ping Guan
Summary: In this study, lysozyme-imprinted mesoporous Zr-based MOF (mesoUiO-66-NH2@MIPs) with specific recognition of lysozyme (Lyz) was prepared using surface imprinting technology. The mesoUiO-66-NH2@MIPs showed excellent hydrophilicity and high loading capacity for macromolecular protein Lyz, and could specifically recognize Lyz from mixed protein systems.
Article
Chemistry, Analytical
Xiaotong Wu, Lei Tan, Yuling Li, Wanqiong Liu, Zhihua Peng, Yanshan Dong, Zeyu Huang, Lin Zhang, Yong Liang
Summary: In this work, a sensor array using dendritic mesoporous silica nanoparticles embedded with three quantum dots was developed for the determination of heavy metal ions. The sensor array showed excellent performance in discriminating and semi-quantifying the heavy metal ions. It simplified the detection procedures and had great practical potential for distinguishing heavy metal ions in raw water and crayfish samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Nanoscience & Nanotechnology
Xiaoxiao Xia, En Yang, Xianfeng Du, Yue Cai, Fei Chang, Daming Gao
Summary: A strategy involving metal ion-imprinted artificial antibodies with recognition sites tagged by fluorescein was developed to construct selective sites for specific metal ions with sensitive optical response signals. Synthesized silica nanoparticles were modified and encapsulated with metal ion-imprinted polymers to achieve high selective recognition and sensitive detection of heavy metal ions through a fluorescence intensity decrease. The LOD concentration for four metal ions was lowered to 10(-9) mol.L(-1), providing a theoretical foundation and technological support for biomimetic synthesis, analyte screening, and detection of highly dangerous materials in the environment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yuheng Qiu, Kaiqi Ding, Liwen Tang, Ziyu Qin, Mengting Li, Xueqiong Yin
Summary: In this study, a water-recyclable chitosan-based La3+-imprinted thermoresponsive hydrogel (CLIT) was developed for the accumulation of rare earth metal La3+ ions from solution. The CLIT exhibited reversible thermosensitivity and imprinted sites for La3+ ions, and showed a high adsorption capacity under optimal conditions. The La3+-adsorbed CLIT could be easily recycled by rinsing with cold water, and it retained good adsorption capability even after multiple cycles of adsorption-desorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Xiao-Ting Yang, Zheng-Wu Wang, Xin Tan, Xia-Yin Yin, Yang Sun, Yi-Zhou Zhu, He-Fang Wang
Summary: To overcome the issues in NADH regeneration, researchers have developed a new light-triggered dark catalyst that can store and release photogenerated electrons to directly reduce NAD+ even without light. This catalyst not only saves energy and operates easily, but also significantly increases the yield of NADH.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Shu-Ting Xu, Cheng Yang, Xiu-Ping Yan
Summary: Cell cycle discrimination is crucial for studying cellular heterogeneity in single-cell analysis based on organic mass spectrometry. A robust protocol using three small molecular indicators was developed to discriminate single cells at different cycle stages in real time. This protocol successfully discriminated single cells at G0/G1, S, and G2/M stages and revealed significant heterogeneity in amino acids, nucleotides, energy metabolic intermediates, and phospholipids among cells at different cycle stages.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Shu-Ting Xu, Xiu-Ping Yan, Hai-Long Qian
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Le Li, Jian Meng, Xuran Bao, Yunpeng Huang, Xiu-Ping Yan, Hai-Long Qian, Chao Zhang, Tianxi Liu
Summary: A direct ink writing 3D printing approach was used to prepare all-printed flexible micro-supercapacitors using rationally designed PEDOT:PSS/MXene composite gels as inks. The MXene nanosheets in the printable inks can enhance the printability of PEDOT:PSS solution and modulate the electronic structures of PEDOT:PSS during a structure transition. The resulting 3D printed micro-supercapacitors and integrated devices exhibit large capacitances, excellent rate performance, and high cycling stability even under exceptional deformations and low temperatures.
ADVANCED ENERGY MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Li-Ya Wang, Li-Jian Chen, Xu Zhao, Yan Lv, Tianxi Liu, Xiu-Ping Yan
Summary: The researchers report an activatable antimicrobial nanoplatform with ultralow-background persistent luminescent (PL) turn-on imaging and therapeutic capability. The platform utilizes chitosan as a linker to immobilize copper ions on the surface of persistent luminescent nanoparticles (PLNPs) to fabricate PLNPs-CS-Cu2+. The PL emission of PLNPs is quenched by Cu2+ under physiological conditions but recovered due to the conversion of Cu2+ into Cu+ by high glutathione (GSH) levels at the infection site. The as-prepared antibacterial nanoplatform shows promise for highly sensitive persistent luminescent imaging and simultaneous treatment of bacterial infection.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jingxiao Chen, Yufeng Wang, Le Li, Yue-E Miao, Xu Zhao, Xiu-Ping Yan, Chao Zhang, Wei Feng, Tianxi Liu
Summary: In this study, an ultrastretchable fluorinated ionogel with high transparency and waterproofness is prepared. The ionogel exhibits stable cross-linking structures, high mechanical elasticity, and self-healing capabilities. It also demonstrates excellent stretchability, mechanical toughness, and underwater strain-sensing performances. This work provides a method for obtaining waterproof ionogel elastomers for next-generation underwater sensors and communications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Kangqi Chang, Zhenzhong Wu, Jian Meng, Minhao Guo, Xiu-Ping Yan, Hai-Long Qian, Piming Ma, Jianhua Zhao, Fangneng Wang, Yunpeng Huang, Tianxi Liu
Summary: Inspired by the nanotopography of cicada wings, a highly sensitive tactile sensor was fabricated by nanotexturing polyaniline nanoneedles on a conductive and elastic carbon skeleton. The sensor exhibited ultrahigh sensitivity, fast response/recovery abilities, and reproducible sensing performance, making it capable of distinguishing motions in a wide pressure range, detecting spatial pressure distribution, and monitoring various gestures in a wireless manner. These excellent performances demonstrate the great potential of nature-inspired tactile sensors for practical human motion monitoring and artificial intelligence applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Yaqiang Duan, Pengwu Xu, Tianxi Liu, Zicheng Wang, Xiuping Yan, Weijun Yang, Deyu Niu, Piming Ma
Summary: Designing a sandwich-like heterostructure of PDMS/SiO2@MXene composites with a floatable interlayer was achieved by regulating the affinity of mixed solvents and SiO2@MXene. The composites exhibited superior EMI shielding effectiveness, stable mechanical property, and wide temperature window in application.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Jiang-Yue Wang, Li-Jian Chen, Xu Zhao, Xiu-Ping Yan
Summary: A pH-responsive colorimetric microneedle (MN) patch made from bromothymol blue (BTB) and silk fibroin meth acryloyl (SilMA) was developed for sensing salmon spoilage. The MN patch could extract tissue fluids from salmon and display color changes based on the pH variation caused by the increase of total volatile basic nitrogen. This method allows rapid determination of salmon spoilage and can be analyzed nondestructively on a smartphone.
Article
Engineering, Environmental
Shuyan Wu, Shichao Cai, Fengyang Qin, Feng He, Tianxi Liu, Xiuping Yan, Zhenyu Wang
Summary: Ball milling is effective in activating and reducing the size of microscale zero valent iron (mZVI) and sulfidating mZVI mechanochemically. However, there are differences in the interaction between chlorinated ethenes (CEs) and ball milled mZVI (mZVIbm) and mechanochemically sulfidated mZVI (S-mZVIbm) that are not well understood. This study found that simple ball milling exposed active Fe0 sites, while mechanochemical sulfidation decreased Fe0 sites and increased S2 sites. The sulfidation process enhanced the reactivity of TCE dechlorination the most, followed by PCE and 1,1-DCE, but reduced the reactivity of trans-DCE, cis-DCE, and VC compared to simple ball milling. Sulfidation also improved the electron efficiency of CE dechlorination, except for cis-DCE and VC. The kSA of cis-DCE, VC, and trans-DCE dechlorination positively correlated with the sulfide content.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Tian-Tian Ma, Cheng Yang, Hai-Long Qian, Piming Ma, Tianxi Liu, Xiu-Ping Yan
Summary: The development of novel functional materials for the effective separation of isomers is important in various fields. The fabrication of a trifluoromethyl-functionalized 2D COF, TpTFMB, was reported for isomer separation. TpTFMB exhibited various functions such as hydrogen bonding, dipole interaction, and steric effect, enabling the high-resolution separation of different types of isomers. This work provides a new strategy for designing efficient isomer separation materials.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Manufacturing
Minhao Guo, Yufan Zhang, Chun Huang, Xu Zhao, Xiu-Ping Yan, Yunpeng Huang, Le Li, Tianxi Liu
Summary: This study successfully developed a novel shape memory polyimide aerogel composite with a high programming temperature and excellent shape recovery capability. By regulating molecular interactions and pore structures, the desired thermo-mechanical performances were achieved, showing great potential for widespread applications in harsh environments.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2023)
Article
Chemistry, Applied
Qing Huang, Lixia Yan, Haodong Wei, Xingjian Ye, Wenlong Wang, Cheng Yang, Xiu-Ping Yan, Yi Zhang
Summary: Heat treatment and the use of additives in food processing can introduce nanomaterials, which have raised concerns due to the lack of toxicological investigation and market standards. This study focused on the structural properties and cytotoxicity of fluorescent carbon nanoparticles (FCNPs) in fried bamboo charcoal peanuts. It was found that FCNPs extracted from charcoal shells and peanut kernels had different particle sizes and water solubility properties. Furthermore, the cellular endocytosis and toxic effects of FCNPs were explored, with charcoal-shell FCNPs showing slightly higher toxicity compared to peanut kernel FCNPs.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Engineering, Environmental
Li-Hong Su, Hai -Long Qian, Cheng Yang, Chuanxi Wang, Zhenyu Wang, Xiu- Ping Yan
Summary: This study presents a facile surface imprinting approach using dopamine to generate imprinted cavities on the surface of irreversible COF for efficient extraction of fluoroquinolones (FQs) in food samples. The resulting MI-COF exhibited exceptional adsorption capacity, with a 2.2-fold enhancement compared to nonimprinted COF. Furthermore, MI-COF was successfully employed as an adsorbent coupled with HPLC for the simultaneous determination of enrofloxacin, norfloxacin, and ciprofloxacin, showing low limits of detection, high precision, and satisfactory recoveries in food samples.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Kangqi Chang, Zhenzhong Wu, Jian Meng, Minhao Guo, Xiu-Ping Yan, Hai-Long Qian, Piming Ma, Jianhua Zhao, Fangneng Wang, Yunpeng Huang, Tianxi Liu
Summary: We propose a simple strategy to fabricate a highly sensitive tactile sensor by nanotexturing erected polyaniline (PANI) nanoneedles on a conductive and elastic three-dimensional (3D) carbon skeleton. The developed sensor exhibits ultrahigh sensitivity, fast response/recovery abilities, and reproducible sensing performance, making it capable of distinguishing motions, detecting spatial pressure distribution, and monitoring various gestures wirelessly.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
