期刊
BIOSENSORS & BIOELECTRONICS
卷 24, 期 8, 页码 2334-2338出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2008.12.011
关键词
Surface plasmons; Nanoholes; Subwavelength holes; SPR; Liposomes
类别
资金
- DARPA/MTO N/MEMS S&T Fundamentals Program
- NIH [5R01HG003828-04, 5R21EB004333-02]
- National Science Foundation [ECS-0335765]
We performed multiplexed sensing on nanohole array devices to simultaneously obtain information on molecular absorption, scattering, and refractive-index change, which were distinguished by using different-array structures with distinct optical behavior. Up to 25 arrays were fabricated within a 65 mu m x 50 mu m area to provide real-time information of the local surface environment. The performance of multiplexed sensing was examined by flowing NaCl, Coomassie blue, bovine serum albumin, and liposome solutions that exhibit different visible light absorption/scattering properties and different refractive indices. Experimental artifacts from light source fluctuation, sample injections, and light scattering induced by aggregates in solutions were detected by monitoring superwavelength holes or nanohole arrays with different periodicity and hole diameters. (C) 2008 Elsevier B.V. All rights reserved.
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