Article
Chemistry, Physical
Seo-Eun Lee, Se-Eun Jeong, Jae-Sang Hong, Hyungsoon Im, Sei-Young Hwang, Jun Kyun Oh, Seong-Eun Kim
Summary: In this study, a simple and sensitive AuNP-coated magnetic bead (AMB)-based electrochemical biosensor platform was developed. The platform was successfully utilized for the detection of extracellular vesicles, demonstrating the potential application of biosensors in immunoassays.
Article
Chemistry, Analytical
Bryan Gosselin, Maurice Retout, Raphael Dutour, Ludovic Troian-Gautier, Robin Bevernaegie, Sophie Herens, Philippe Lefevre, Olivier Denis, Gilles Bruylants, Ivan Jabin
Summary: A dipstick assay using silver nanoparticles stabilized by a thin calix[4]arene-based coating was developed for detecting Anti-SARS-CoV-2 IgG in clinical samples. Compared to traditional lateral-flow immunoassays using gold nanoparticles, this silver nanoparticle-based system showed a lower limit of detection and similar signals with a smaller number of particles. The dipstick assay demonstrated impressive results in real clinical samples, with 100% specificity for negative samples and a sensitivity of 73% for positive samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Nirgaman Bage, Pradip Kar
Summary: The study investigated the influence of silver nanoparticles labeled with biomolecules on electrochemical sensing, showing that AgNP labeled layers can serve as ultrasensitive detectors for detecting biotin-avidin couple and sensing concentration changes even at higher concentrations.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Rahman Hallaj, Mahsa Mottaghi, Zhaleh Ghafary, Fahimeh Jalali
Summary: This study presents a sandwich-type electrochemical immunosensor for the detection of hepatitis B virus surface antigen. By incorporating magnetic nanoparticles and gold nanoparticles, an amplified electrical signal is achieved, allowing for successful quantification of HBsAg concentration in serum.
MICROCHEMICAL JOURNAL
(2022)
Article
Food Science & Technology
Shiqian Fu, Xinyan Yang, Lidong Pang, Shasha Cheng, Danliangmin Song, Xue Qin, Chaoxin Man, Yujun Jiang
Summary: In this study, a novel fluorescence aptasensor was developed for rapid and sensitive detection of Salmonella Typhimurium (S. Typhimurium). The aptasensor exhibited high selectivity and sensitivity, and showed excellent application for detection in artificially contaminated milk.
Article
Engineering, Environmental
Zhongnan Huang, Zhenglian Li, Zhimin Weng, Paramasivam Balasubramanian, Mingchun Lai, Wei Chen, Juewen Liu, Huaping Peng
Summary: In this study, a model system was developed to evaluate the effect of electrocatalysis (EC) on electrochemiluminescence (ECL) through kinetic analysis of electrocatalytic reactions. The results demonstrated a dual EC-mediated ECL enhancement and identified the catalytically active sites. With a better understanding of the EC mechanism, the researchers successfully used EC to regulate ECL and developed a biosensor with a record low limit of detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Yan-Fang Xue, Heng Li, Qingmei Ge, Mao Liu, Zhu Tao, Hang Cong
Summary: A supramolecular chiral electrode was constructed by layer-by-layer assembly of gold nanoparticles and S-chiral multifarene on a glassy carbon electrode surface for the electroreduction of acetophenone. The optimized electrolysis process showed high yield and enantioselectivity. The experiment demonstrated the stability and recyclability of the novel chiral electrode.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Analytical
Fu Jiao, Fengjing Cao, Yuan Gao, Feng Shuang, Daming Dong
Summary: Flexible-type signal probes and their detection methods are widely used in biosensors, and temperature-based signal probes represent a new research direction. This study proposes a novel sensing method that uses infrared radiance as the signal probe and implements the conversion of immunoassay using a controlled aluminum plate. Two readout systems, including a scientific grade infrared camera and a smartphone-based thermal camera, are developed for detection. The sensors show excellent quantitative model performances with a low detection limit when detecting biomarkers such as human IgG.
Article
Chemistry, Analytical
Hongkun Li, Qianqian Cai, Xiaoshi Yan, Guifen Jie, Guitao Jie
Summary: A novel ratiometric electrochemical biosensor was developed for sensitive detection of microRNA using walker amplification technique. The biosensor showed excellent sensitivity and high specificity, with a wide linear detection range of target concentration. The internal reference signal of MB and ratio of Ag NPs to MB greatly reduced background noise, making it a promising tool for bioanalysis and disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Electrochemistry
Mohsen Shariati, Mahdi Sadeghi, Sina Mohammadivand Khoshkhoo, Nazanin Azimi
Summary: A highly sensitive and cost-free field effect transistor (FET) biosensor based on zinc oxide nanowires (NWs) has been developed for the specific detection of DNA and streptavidin. Under electrochemical gate modulation, the electronic properties of the NWs were altered by the binding of analytes, allowing for the immobilization of target analyte receptors through electrochemical treatment. The biosensor demonstrated attomolar sensitivity and could differentiate between a complementary DNA strand and a single nucleotide polymorphism (SNP).
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Taohong Zhou, Weihao Ji, Hongli Fan, Li Zhang, Xugang Wan, Zhiyong Fan, Gang Logan Liu, Qingzhi Peng, Liping Huang
Summary: Food safety related to drug residues in food is a widespread concern. We developed a MSPRAN biosensor platform for small-molecule detection, which provides fast and reliable results, facile operation, and is relatively cost-effective for application in food safety testing, environmental monitoring, or clinical diagnostics.
Article
Chemistry, Applied
Yuanshang Wang, Pengfei Du, Am Abd El-Aty, Ge Chen, Huiyan Jia, Xueyan Cui, Emel Oz, Yudan Zhang, Xiuyuan Zhang, Guoxin Qin, Feiyan Yan, Jing Wang, Maojun Jin, Bruce D. Hammock
Summary: A novel visual method for detecting triazophos using competitive bio-barcode immunoassay was established, with a detection range between 0.05 and 10 ng/mL. The method showed high percent recovery and stability, offering a new insight for rapid detection of small molecule pesticides in various matrices.
Article
Chemistry, Analytical
Lin Liu, Yong Chang, Xingyue Ji, Jiayu Chen, Mengyu Zhang, Suling Yang
Summary: A sensitive electrochemical biosensor for telomerase detection was developed by integrating homogeneous extension and hybridization reactions and surface-tethered detection. The biosensor exhibited strong electrochemical signals from the oxidation of Fc tags when the bio-DNA/DNA/Fc-AuNP hybrids were tethered to streptavidin-modified electrodes through specific avidin-biotin interactions. This method has great potential in clinical diagnosis and anti-cancer drug development.
Article
Chemistry, Inorganic & Nuclear
Hao-Tian Zhu, Yuan-Yuan Ma, Jing Du, Hua-Qiao Tan, Yong-Hui Wang, Yang-Guang Li
Summary: Four POM-based organic-inorganic hybrid compounds were synthesized and their structures were expanded into three-dimensional frameworks by modifying {AgP5W30} clusters. These materials showed good electrocatalytic activity and high sensitivity as nonenzymatic electrochemical sensor materials for detecting hydrogen peroxide (H2O2), with low detection limit. Compared to other types of POM-based materials, these {AgP5W30}-based materials exhibited superior performance, which can be attributed to the high-negative charge of {AgP5W30} clusters and the synergistic effect with transition metals.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Soledad Carinelli, Inigo Fernandez, Jose Luis Gonzalez-Mora, Pedro A. Salazar-Carballo
Summary: This study reports on the fabrication and characterization of novel hemoglobin-modified magnetic nanoparticles for bovine mastitis detection. The nanoparticles were used as solid support for immoblization of the biomarker Haptoglobin, and an electrochemical detection method was applied for quantification. The strategy showed a wide detection range and excellent accuracy, offering a real alternative for on-farm screening of sub-clinical bovine mastitis.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Jose Francisco Bergua, Ruslan Alvarez-Diduk, Andrea Idili, Claudio Parolo, Marc Maymo, Liming Hu, Arben Merkoci
Summary: The quantitative detection of different molecular targets is crucial for various activities. This study presents a smartphone-based device that enables high-precision laboratory analysis directly at the point of care.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Amadeo Sena-Torralba, Ruslan Alvarez-Diduk, Claudio Parolo, Andrew Piper, Arben Merkoci
Summary: This article reviews the application of nanomaterial-based lateral flow assays (LFAs) in point-of-care diagnostics. By incorporating novel nanomaterials as signal transducers or receptor immobilization platforms, the analytical capabilities of LFAs have been improved. The article highlights strategies that can address the limitations of current LFAs and have shown commercial feasibility.
Review
Biochemical Research Methods
Celia Toyos-Rodriguez, David Valero-Calvo, Alfredo de la Escosura-muniz
Summary: The abusive use of antimicrobial compounds and the associated appearance of antimicrobial resistant strains pose a major threat to human health. Improved antimicrobial administration requires faster diagnosis and detection of resistances. Electrochemical methods used in antimicrobial susceptibility testing (AST), particularly for evaluating new drug candidates, have shown significant potential. The role of nanomaterials in these biosensing platforms is relatively minor compared to other applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Ana Rubio-Monterde, Daniel Quesada-Gonzalez, Arben Merkoci
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Annalisa Scroccarello, Ruslan Alvarez-Diduk, Flavio Della Pelle, Cecilia de Carvalho Castro e Silva, Andrea Idili, Claudio Parolo, Dario Compagnone, Arben Merkoci
Summary: The combination of two-dimensional materials and metal nano-particles allows the fabrication of nanocomposites for high-performance smart devices and biosensors. This study proposes a single-step technique to produce reduced graphene oxide conductive films integrating naked noble metal nano-particles. The produced films have been fully characterized and integrated into various sensors to detect different analytes with high accuracy.
Article
Nanoscience & Nanotechnology
Lei Zhao, Giulio Rosati, Andrew Piper, Cecilia de Carvalho Castro e Silva, Liming Hu, Qiuyue Yang, Flavio Della Pelle, Ruslan R. Alvarez-Diduk, Arben Merkoci
Summary: Graphene-based materials have unique properties that make them suitable for electro-chemical biosensing. However, the production of graphene electrodes on a large scale remains challenging. This study presents a simple and fast method for fabricating reduced graphene oxide electrodes using direct writing and stamp-transferring techniques. The biosensors developed using these electrodes demonstrated excellent sensitivity and detection limits for Escherichia coli, making them suitable for real-world applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
David Valero-Calvo, Celia Toyos-Rodriguez, Francisco Javier Garcia-Alonso, Alfredo de la Escosura-Muniz
Summary: For the first time, nanoparticles are suggested as carriers of an immobilized enzymatic substrate in nanoporous alumina membranes to enhance nanochannel blocking and improve enzyme determination efficiency. Polystyrene nanoparticles modified with streptavidin are proposed as carrier agents, providing steric and electrostatic blockage due to their charge at different pH values. The effect of using negatively charged and positively charged redox indicator ions on electrostatic blockage is studied for the first time. The approach shows great potential in point-of-care diagnostics with cheap and fast sensing methodology, allowing detection of clinically relevant levels of matrix-metalloproteinase 9 with good reproducibility and selectivity.
Article
Nanoscience & Nanotechnology
Lourdes Rivas, Arben Merkoci, Liming Hu, Claudio Parolo, Andrea Idili
Summary: The use of nanomaterials as colorimetric labels in point-of-care devices can enhance sensitivity. By optimizing the synthesis of gold and iridium oxide nanoflowers, researchers have achieved improved colorimetric signals and sensitivity, making them potential candidates for the next generation of optical lateral flow assays.
ACS APPLIED NANO MATERIALS
(2023)
Article
Food Science & Technology
Beatriz Perez-Fernandez, Britt Marianna Maestroni, Shuichi Nakaya, Sofia Bussalino, Christina Vlachou, Alfredo de la Escosura-Muniz
Summary: Aflatoxins (AFs) can be produced by fungi in nuts, and their levels in food are strictly regulated due to their adverse effects on humans. Electrochemical immunosensing is a sensitive and cost-effective alternative to standard AFs analysis, and has been used for the detection of AFB1. However, the determination of total AFs is not widely reported with electrochemical immunosensors.
Article
Chemistry, Multidisciplinary
Gabriel Maroli, Vernalyn Abarintos, Andrew Piper, Arben Merkoci
Summary: This article reports a method of fabricating nanoband electrodes using low-cost materials and equipment, which have advantages of low cost, fast production, and high flexibility. The research shows that these nanoband electrodes have single molecule sensitivity for the detection of DNA sequences specific to SARS-CoV-2.
Article
Chemistry, Analytical
Ana M. Villa-Manso, Tamara Guerrero-Esteban, Felix Pariente, Celia Toyos-Rodriguez, Alfredo de la Escosura-Muniz, Monica Revenga-Parra, Cristina Gutierrez-Sanchez, Encarnacion Lorenzeo
Summary: A novel immunosensor based on electrochemiluminescence resonance energy transfer (ECL-RET) has been developed for the sensitive determination of N protein of the SARS-CoV-2 coronavirus. The immunosensor utilizes bifunctional core@shell nanoparticles as ECL acceptor and [Ru(bpy)(3)](2+) as ECL donor. It demonstrates a wide linear response to the concentration of N protein with a detection limit of 1.27 pg/mL, high stability, and specificity. The immunosensor has been successfully applied for quantification of N protein in saliva samples and showed consistent results with a commercial colorimetric ELISA kit.
Article
Chemistry, Multidisciplinary
Flavio Della Pelle, Qurat Ul Ain Bukhari, Ruslan Alvarez Diduk, Annalisa Scroccarello, Dario Compagnone, Arben Merkoci
Summary: We introduce a CO2 laser plotter-based technology for the production of heterostructures (HTs) comprising reduced graphene oxide (rGO) and 2D transition metal dichalcogenides (TMDs). The laser treatment converts GO into highly exfoliated and conductive rGO decorated with small TMD/TM-oxide nanoflakes. The freestanding LIHT films obtained exhibit excellent performance as self-contained sensors with nanomolar limits of detection and high fouling resistance.
Article
Chemistry, Multidisciplinary
Yang Qiuyue, Emily P. Nguyen, David Panacek, Veronika Sedajova, Vitezslav Hruby, Giulio Rosati, de Carvalho Castro Silva Cecilia, Aristides Bakandritsos, Michal Otyepka, Arben Merkoci
Summary: Heavy metal pollutants are highly toxic and pose great concern in environmental monitoring. Electrochemical detection, hindered by mutual interferences of heavy metal ions, is a main technique with limited sensitivity to Cd2+ ions. This study introduces a metal-free and sustainable nanomaterial, cysteamine covalently functionalized graphene (GSH), which significantly enhances the sensitivity of screen-printed carbon electrode (SPCE) to Cd2+ ions while maintaining sensitivity to other heavy metals. The enhancement is attributed to the grafted thiols on the GSH sheets with strong affinity to Cd2+ ions, based on Pearson's principle. The GSH-modified SPCE also exhibits high reusability and outperforms existing SPCEs modified by non-covalently functionalized graphene derivatives. The GSH-SPCE is successfully validated in tap water.
Article
Chemistry, Multidisciplinary
Massimo Urban, Giulio Rosati, Gabriel Maroli, Flavio Della Pelle, Andrea Bonini, Laszlo Sajti, Mariangela Fedel, Arben Merkoci
Summary: This study presents a new sintering method called click sintering, which uses a catalytic reaction to enhance and tune the nanostructuration of gold nanoparticle inks. This one-step approach allows for the creation of conductive and electroactive nanoporous thin films without the need for complex post-treatments. The properties of the film can be adjusted by controlling the reaction conditions. The click sintering strategy offers a rapid, easy, and inexpensive technique for fabricating functional nanostructures, with potential applications in flexible electronics, biosensing, energy, and catalysis.
Article
Biochemical Research Methods
Liming Hu, Enric Calucho, Celia Fuentes-Chust, Claudio Parolo, Andrea Idili, Ruslan Alvarez-Diduk, Lourdes Rivas, Arben Merkoci
Summary: This manuscript highlights the importance of better characterised bioreceptors for the development of point-of-care diagnostic devices. The challenges faced in finding suitable antibodies for the detection of SARS-CoV-2 nucleoprotein in a lateral flow assay are discussed.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
