Article
Biochemistry & Molecular Biology
Costanza Gianni, Claudia Piervincenzi, Daniele Belvisi, Silvia Tommasin, Maria Ilenia De Bartolo, Gina Ferrazzano, Nikolaos Petsas, Giorgio Leodori, Nicoletta Fantoni, Antonella Conte, Alfredo Berardelli, Patrizia Pantano
Summary: This study investigated the microstructural damage of white matter bundles connecting subcortical and cortical regions in patients with cervical dystonia and blepharospasm. The results showed significant differences in diffusion tensor imaging metrics between the patient groups and healthy subjects, suggesting a common pathology in these two types of dystonia.
Article
Geriatrics & Gerontology
Yahui Ouyang, Dong Cui, Zilong Yuan, Zhipeng Liu, Qing Jiao, Tao Yin, Jianfeng Qiu
Summary: Population aging has led to a focus on changes in elderly brains, particularly in white matter fibers. This study used various parameters to analyze age-related changes in white matter fibers, finding significant differences in FA, MD, AD, and RD between young and middle-age groups. Deterministic fiber tracking showed a correlation between fiber length and age, with specific fibers identified as potential image markers for age-related white matter changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Oncology
Xin Wu, Zongqi Wang, Haiying Li, Xueshun Xie, Jiang Wu, Haitao Shen, Xiang Li, Zhong Wang, Gang Chen
Summary: The study found that the loss of MCT1 after subarachnoid hemorrhage may be one of the mechanisms of white matter damage, and miR-29b and miR-124 may contribute to this damage through negative regulation of MCT1 levels. Rehabilitation training can promote the upregulation of MCT1 and improve behavioral abilities in rats.
FRONTIERS OF MEDICINE
(2021)
Article
Psychiatry
Taro Mizobe, Keisuke Ikari, Hirofumi Tomiyama, Keitaro Murayama, Kenta Kato, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao
Summary: This study found widespread white matter abnormalities in the brains of patients with hoarding disorder, which are associated with the severity of hoarding symptoms and cognitive dysfunction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Oncology
Aiman Abdul Manan, Noorazrul Azmie Yahya, Nur Hartini Mohd Taib, Zamzuri Idris, Hanani Abdul Manan
Summary: Diffusion tensor imaging is a non-invasive neuroimaging tool used to visualize the white matter tract of the brain. This study aims to assess the characteristics and criteria of white matter tract microstructure integrity changes in brain tumor patients.
Article
Neurosciences
Miriam H. A. Bopp, Julia Emde, Barbara Carl, Christopher Nimsky, Benjamin Sass
Summary: This study compared DTI- and DKI-based fiber tractography in CST, OR, and AF, finding that DKI showed significantly larger tract volumes in CST, similar results in OR with an exception in the right OR of patients, and comparable results in AF with DTI-based fiber tractography showing even significantly larger tract volumes in patients. DKI-based fiber tractography contributes to advanced visualization under clinical time constraints for CST and OR, while other models should be considered for AF.
Review
Endocrinology & Metabolism
Ferdy S. van Geest, Nilhan Gunhanlar, Stefan Groeneweg, W. Edward Visser
Summary: Genetic defects in MCT8 result in a disorder characterized by severe intellectual and motor disabilities, as well as a chronic thyrotoxic state in peripheral tissues. Triiodothyroacetic acid is currently being investigated as an effective and safe treatment for peripheral thyrotoxicosis. The impact of this treatment on the neurocognitive phenotype is still under study.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Jian Yang, Xiaowei Jiang, Shengnan Wei, Xin Deng, Yue Zhu, Miao Chang, Zhiyang Yin, Haiyang Geng, Yanqing Tang, Xu Dai
Summary: Compared to DTI parameters, DKI parameters showed more sensitivity and stability in probing the local microstructure, especially in exploring cerebral alterations in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Tanushka Anand, Abdullah Ishaque, Daniel Ta, Muhammad Umer Khan, Komal Bharti, Andrew Wu, Dennell Krebs, Christian Beaulieu, Peter Seres, Sanjay Kalra
Summary: DKI can provide complementary information to DTI for understanding the pathology and microstructural alterations in patients with motor neuron disease and UMN dysfunction. Abnormalities in the CST and CC were observed, with higher mean and radial diffusivity and lower FA, kurtosis anisotropy, MK, and RK in patients compared to controls. The changes were concentrated in specific areas and correlated with disease progression rate and UMN burden.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Dongha Lee, Hae-Jeong Park
Summary: This study investigates the three-dimensional organization of neural fiber connections in the white matter of the brain. By analyzing connection distribution maps and related parameters, the study reveals the patterns of major fiber bundle connections in the white matter.
Article
Geriatrics & Gerontology
Benjamin Yeske, Jiancheng Hou, Nagesh Adluru, Veena A. Nair, Vivek Prabhakaran
Summary: This study revealed significant structural differences in white matter regions associated with language production in young adults, compared to older adults who showed significant correlations between language production and MD values. This suggests that white matter structures play a crucial role in age-related changes in language production.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Donglai Jing, Yaojing Chen, Kexin Xie, Yue Cui, Chunlei Cui, Li Liu, Hui Lu, Jing Ye, Ran Gao, Lin Wang, Zhigang Liang, Zhanjun Zhang, Liyong Wu
Summary: The study aimed to explore white matter alterations in preclinical familial Creutzfeldt-Jakob disease using DTI. Results showed integrity changes in multiple WM tracts during preclinical stage of fCJD, with no neurological symptoms observed during follow-up. Increased MD in various WM tracts in carriers overlapped patterns observed in symptomatic CJD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Shirui Cheng, Xiaohui Dong, Jun Zhou, Chenjian Tang, Wenhua He, Yang Chen, Xinyue Zhang, Peihong Ma, Tao Yin, Yimei Hu, Fang Zeng, Zhengjie Li, Fanrong Liang
Summary: Patients with knee osteoarthritis (KOA) exhibit structural and functional alterations in white matter, as revealed by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Extensive white matter changes are observed in sensorimotor and pain-related regions in KOA patients. Additionally, a negative correlation is found between disease severity and white matter abnormalities in KOA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Martin Domin, Brenton Hordacre, Pavel Hok, Lara A. Boyd, Adriana B. Conforto, Justin W. Andrushko, Michael R. Borich, Richard C. Craddock, Miranda R. Donnelly, Adrienne N. Dula, Steven J. Warach, Steven A. Kautz, Bethany P. Lo, Christian Schranz, Na Jin Seo, Shraddha Srivastava, Kristin A. Wong, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Sook-Lei Liew, Martin Lotze
Summary: The study found that stroke patients with severe CST damage rely on residual pathways for better upper limb function recovery.
Article
Neurosciences
Xiaoyu Xu, Yuying Jin, Ning Pan, Muqing Cao, Jin Jing, Jingwen Ma, Xiaoxuan Fan, Si Tan, Xiaojing Song, Xiuhong Li
Summary: Cantonese and Mandarin, both logographic languages, differ mainly in terms of phonology. This study investigates the structural differences in brain white matter between Cantonese-Mandarin bilinguals and Mandarin monolinguals, and finds that the bilinguals have higher diffusivity and specific correlations with phonological processing.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)