Review
Engineering, Environmental
Jyotsana Mehta, Neeraj Dilbaghi, Nitin Kumar Singhal, Giovanna Marrazza, Ajeet Kaushik, Sandeep Kumar
Summary: This review summarizes the recent advancements in electrochemiluminescent sensors based on quantum dots (QDs), highlighting their structural properties, modification methods, and roles in signal detection and specific targeting.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Arun Ashokan, Paul Mulvaney
Summary: Solution-phase spectroelectrochemistry was used to study electron injection into colloidal CdSe quantum dots in THF. The results showed reversible optical changes on a time-scale of minutes, with the injection of electrons leading to quenching of photoluminescence. The number of electrons injected into the QDs depended on the electrode potential and QD size, with most injection occurring below the band edge.
CHEMISTRY OF MATERIALS
(2021)
Article
Environmental Sciences
Mingxuan Jia, Boyu Jia, Xiaofang Liao, Linchun Shi, Zheng Zhang, Miao Liu, Lidong Zhou, Donghui Li, Weijun Kong
Summary: A CdSe@CdS quantum dots-based label-free ECL aptasensor was developed for specific and sensitive detection of OTA, with excellent stability and strong ECL intensity. The sensor showed superior sensitivity for OTA with a wide linear concentration range after optimizing crucial conditions, demonstrating potential for various applications.
Article
Food Science & Technology
Shasha Feng, Wei Hu, Fubin Pei, Zhiwei Liu, Bin Du, Xihui Mu, Bing Liu, Qingli Hao, Wu Lei, Zhaoyang Tong
Summary: A sensitive dual-readout immunosensor combining fluorescence and electrochemiluminescence (ECL) detection was developed for ricin detection. The sensor utilized CdSe/ZnS quantum dots as dual-signal function probes and a streptavidin-biotin signal amplification system. The sensor exhibited high sensitivity and could successfully detect ricin in complex matrices.
Article
Chemistry, Analytical
Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou
Summary: This study proposes a method to achieve chemiluminescence with different wavelengths and intensities by adjusting triggering agents, which shows promising potential for applications in immunoassays and other fields.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiang Hu, Ying Wang, Xiong Zuping, Pei Song, Ai-Jun Wang, Zhaosheng Qian, Pei-Xin Yuan, Tiejun Zhao, Jiu-Ju Feng
Summary: In this study, an aggregation-enhanced PEC photosensitizer PPIX-[BMIm] was prepared by electrostatic bonding, and its PEC performance in a binary solvent of water and DMSO was studied. A label-free PEC cytosensor was built using PPIX-[BMIm], which showed a wide linear range and low limit of detection for detecting leukemia cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Dongquan Leng, Jihao Zhao, Xiang Ren, Rui Xu, Lei Liu, Xuejing Liu, Yuyang Li, Qin Wei
Summary: In this study, a split-type immunoassay strategy initiated by cation exchange and altering the capacity of an electron donor was optimized, using MoSe2/CdSe as a photoelectrode substrate and silver ions as the initiator of CE. The combination of ascorbate oxidase with MSNs improved the sensor's sensitivity and reliability, resulting in a broad linear range and low detection limit when applied to neuron-specific enolase.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Physical
Fangxin Du, Yequan Chen, Chengda Meng, Baohua Lou, Wei Zhang, Guobao Xu
Summary: This review summarizes recent advances in ECL strategies with multiple-signal outputs, including ratiometric ECL, ECL multiplex immunoassay (MIA), and ECL imaging, discussing their signal generation strategies and applications in immunoassays. Challenges and prospects in this field are also addressed.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Yongjuan Meng, Jinling Pu, Jiamei Gan, Jianping Li
Summary: A composite of ZIF-8 doped with CdSe quantum dots was synthesized, and a molecularly imprinted electrochemiluminescence sensor was constructed. The sensor showed high sensitivity and specificity for the detection of estriol, with a detection limit of 8.9 x 10(-16) mol L-1. It was successfully applied in the determination of estriol in serum samples.
Article
Chemistry, Multidisciplinary
Weiliang Guo, Ping Zhou, Lei Sun, Hao Ding, Bin Su
Summary: The study utilized microtube electrode (MTE) and microscopy to measure the thickness of ECL layer (TEL) in order to decipher reaction mechanisms. Different systems exhibited varying changes in ECL pattern and TEL, with the catalytic route playing a significant role in these variations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Mahsa Naghavi Sheikholeslami, Foad Salehnia, Guobao Xu, Hodjattallah Rabbani, Ebtesam Sobhanie
Summary: The rapid spread of SARS-CoV-2 has raised the need for efficient and rapid diagnostic tools. In this study, an electrochemiluminescence (ECL)-based detection system was developed and trained using machine learning algorithms to accurately diagnose COVID-19 with over 90% accuracy. The system provides a cost-effective and time-saving alternative to traditional testing methods.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ruirui Li, Zikang Zhu, Peng Pan, Jun Liu, Baozeng Zhou, Chengxin Liu, Zhengchun Yang, John Wang, Xu Li, Xin Yang, Jiayuan Chang, Huimin Niu
Summary: In this study, nitrogen-doped carbon quantum dots (N-CQDs) were prepared for a paper-based electrochemiluminescence (ECL) sensor, showing excellent stability, reproducibility, and selectivity in detecting Cu2+ ions, with a wide linear relationship ranging from 0.01 to 1000 μM. This one-step synthesis of N-CQDs provides a feasible method for preparing portable paper-based ECL sensors for future applications.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yipeng Li, Ruirui Li, Zikang Zhu, Jun Liu, Peng Pan, Yangyang Qi, Zhengchun Yang
Summary: In this study, nitrogen-doped carbon quantum dots and ZnO composites were prepared to enhance the electrochemiluminescence performance of carbon quantum dots for copper ion detection. The composite ZnO materials with paper-based modified electrodes showed improved ECL performance, demonstrating the principle of signal enhancement. The sensitivity and detection limit of the paper ECL sensor were improved, indicating the potential application of N-CQDs/ZnO composites in ECL signal amplification.
MICROCHEMICAL JOURNAL
(2022)
Article
Electrochemistry
Xiaoli Qin, Liuqing Yang, Ziying Zhan, Edward Cieplechowicz, Kenneth Chu, Congyang Zhang, Sara Jahanghiri, Gregory C. Welch, Zhifeng Ding
Summary: The ECL performance and absolute efficiency of a graphene-like N-annulated PDI derivative, tPDI2N-trimethylbenzyl (tPDI2N-TMB), in annihilation and coreactant pathways with TPrA and BPO were investigated. The relative ECL efficiency of the tPDI2N-TMB/TPrA system was found to be 165%, demonstrating its high potential as an optoelectronically active material.
ELECTROCHIMICA ACTA
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)