Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence

(2013) Michael S. Wolin   BIOCHEMICAL JOURNAL

Aggregation Prone Regions and Gatekeeping Residues in Protein Sequences

(2013) Jacinte Beerten et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Folding of a Cyclin Box

(2013) Lucía B. Chemes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

(2012) Cristian A. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Transmissible Proteins: Expanding the Prion Heresy

(2012) Claudio Soto   CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

(2012) Alexander Kirilyuk et al.   PLoS One

First-order rate-determining aggregation mechanism of p53 and its implications

(2012) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

(2012) R. Wilcken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits

(2012) Massimo Stefani   PROGRESS IN NEUROBIOLOGY

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Potential roles for prions and protein-only inheritance in cancer

(2011) H. Antony et al.   CANCER AND METASTASIS REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild-Type Tumor Protein p53

(2011) Jorge Nieva et al.   CHEMISTRY & BIOLOGY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

The client protein p53 adopts a molten globule–like state in the presence of Hsp90

(2011) Sung Jean Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance

(2011) Ricardo Aramayo et al.   NUCLEIC ACIDS RESEARCH

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

(2011) L. I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

(2011) Ines Moreno-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of RNA in mammalian prion protein conversion

(2011) Mariana P. B. Gomes et al.   Wiley Interdisciplinary Reviews-RNA

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

(2010) Claudia B. Levy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

(2010) Tuane C. R. G. Vieira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

(2010) S. Rajagopalan et al.   NUCLEIC ACIDS RESEARCH

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

Prion hypothesis: the end of the controversy?

(2010) Claudio Soto   TRENDS IN BIOCHEMICAL SCIENCES

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

(2009) Jerson L. Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation

(2009) Daniella Ishimaru et al.   BIOCHEMISTRY

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

PrP interactions with nucleic acids and glycosaminoglycans in function and disease

(2009) Jerson et al.   Frontiers in Bioscience-Landmark

In Vitro Recapitulating of TP53 Mutagenesis in Hepatocellular Carcinoma Associated With Dietary Aflatoxin B1 Exposure

(2009) Ahmad Besaratinia et al.   GASTROENTEROLOGY

The p53 Core Domain Is a Molten Globule at Low pH

(2009) Ana Paula D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

30 years and a long way into p53 research

(2009) Pierre Hainaut et al.   LANCET ONCOLOGY

A comparison between p53 accumulation determined by immunohistochemistry andTP53mutations as prognostic variables in tumours from breast cancer patients

(2008) Jan Alsner et al.   ACTA ONCOLOGICA

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies

(2008) Stefania Rigacci et al.   BIOPHYSICAL JOURNAL

p53 isoforms - A conspiracy to kidnap p53 tumor suppressor activity?

(2008) V. Marcel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE