期刊
BIOSCIENCE REPORTS
卷 32, 期 1, 页码 17-23出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20110009
关键词
collapsin response mediator protein-2 (CRMP2); endocytic trafficking; Eps15 homology (EH); Eps15 homology-domain-containing protein (EHD); GTPase-activating protein (GAP); Rab; transferrin receptor (TfR)
资金
- National Institutes of Health (NIH) [R01GM074876, 1R01GM087455]
- Nebraska Center for Cellular Signaling NIH [P20 RR018759]
Endocytic trafficking is a highly organized process regulated by a network of proteins, including the Rab family of small GTP-binding proteins and the C-terminal EHDs (Eps15 homology-domain-containing proteins). Central roles for Rab proteins have been described in vesicle budding, delivery, tethering and fusion, whereas little is known about the functions of EHDs in membrane transport. Common effectors for these two protein families have been identified, and they facilitate regulation of sequential steps in transport. By comparing and contrasting key aspects in their modes of function, we shall promote a better understanding of how Rab proteins and EHDs regulate endocytic trafficking.
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