期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 78, 期 10, 页码 1669-1676出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.930327
关键词
commensal bacteria; mast cells; allergy; degranulation
类别
资金
- JSPS KAKENHI [23580186]
- Grants-in-Aid for Scientific Research [26292065, 23580186] Funding Source: KAKEN
The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca2+ signaling upon the high affinity IgE receptor (Fc epsilon RI) cross-linking.
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