期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 77, 期 12, 页码 2517-2519出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.130663
关键词
tuliposide; tulipalin; MurA
类别
资金
- Japan Society for the Promotion of Science of Japan
(-)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.
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