期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 75, 期 8, 页码 1576-1581出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110277
关键词
intracellular ATP; secondary metabolites; Streptomyces; polyphosphate kinase
类别
资金
- Cooperative Research Program for Agricultural Science and Technology Development [PJ20100301-030-042]
- Rural Development Administration, Republic of Korea [PJ0080932011]
- Brain Korea 21 Project
The addition of extracellular ATP (exATP) to four Streptomyces strains had similar effects: low exATP levels stimulated antibiotic production and high levels reduced it. Compared with antibiotic production, the concentrations of intracellular ATP (inATP) in the tested strains were opposite, which suggests a role of inATP in regulating secondary metabolite production. Under inactivation of the polyphosphate kinase gene (ppk) in S'treptomyces lividam, we observed the same results: when the inATP level in the mutant strain was lower than in the parent strain, more antibiotic was produced. Combining all the results, a strong inverse relationship between [inATP] and the secondary metabolite production is suggested by this study.
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